Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Clinical Infectious Diseases

Volumn 62, Issue 6, 2015, Pages 795-803

  Ravimohan, Shruthi ^a,b   Tamuhla, Neo ^b   Nfanyana, Kebatshabile ^b   Steenhoff, Andrew P ^b,c,d   Letlhogile, Rona ^b   Frank, Ian ^a   MacGregor, Rob Roy ^a   Gross, Robert ^a,b,c   Weissman, Drew ^a,b   Bisson, Gregory P ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BOTSWANA UPENN PARTNERSHIP   (Botswana)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

ART; Cellular immune function; HIV; Immune reconstitution inflammatory syndrome (IRIS); Tuberculosis

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 6; NEVIRAPINE; PROGRAMMED DEATH 1 RECEPTOR; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; IL6 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ADULT; AGED; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MIXED INFECTION; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUBERCULOSIS ASSOCIATED IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; ADVERSE EFFECTS; BLOOD; BOTSWANA; COINFECTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MICROBIOLOGY; MIDDLE AGED; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; PATHOPHYSIOLOGY; TUBERCULOSIS, PULMONARY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BOTSWANA; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COINFECTION; FEMALE; FLOW CYTOMETRY; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; IMMUNITY, CELLULAR; INTERLEUKIN-6; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PROSPECTIVE STUDIES; TUBERCULOSIS, PULMONARY; YOUNG ADULT;

EID: 84960080760     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ978     Document Type: Article

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