Somatic activating RAS mutations cause vascular tumors including pyogenic granuloma

Journal of Investigative Dermatology

Volumn 135, Issue 6, 2015, Pages 1698-1700

  Lim, Young H ^a   Douglas, Stephanie R ^a   Ko, Christine J ^a   Antaya, Richard J ^a   McNiff, Jennifer M ^a   Zhou, Jing ^a   Choate, Keith A ^a   Narayan, Deepak ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN;

CONGENITAL BLOOD VESSEL MALFORMATION; GENE MUTATION; HETEROZYGOSITY; HUMAN; LETTER; MOLECULAR MECHANICS; PRIORITY JOURNAL; PYOGENIC GRANULOMA; SKIN NODULE; SOMATIC MUTATION; VASCULAR REMODELING; VASCULAR TUMOR; ADOLESCENT; CELL PROLIFERATION; CHILD; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INFANT; MALE; METABOLISM; MUTATION; NEWBORN; PRESCHOOL CHILD;

ADOLESCENT; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GRANULOMA, PYOGENIC; HUMANS; INFANT; INFANT, NEWBORN; MALE; MUTATION; RAS PROTEINS; VASCULAR NEOPLASMS;

EID: 84960078364     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.55     Document Type: Letter

References (15)

1. Ahuja T, Jaggi N, Kalra A et al. (2013) Hemangioma: review of literature. J Contemp Dent Prac 14: 1000-7
2. Browning JC, Eldin KW, Kozakewich HP et al. (2009) Congenital disseminated pyogenic granuloma. Pediatr Dermatol 26:323-7
3. Eerola I, Boon LM, Mulliken JB et al. (2003) Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Am J Hum Genet 73:1240-9
4. Enjolras O, Wassef M, Chapot R (2007) Introduction: ISSVA Classification. Cambridge University Press: Cambridge, UK
5. Fisher GH, Wellen SL, Klimstra D et al. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 15:3249-62
6. Giblin AV, Clover AJ, Athanassopoulos A et al. (2007) Pyogenic granuloma-the quest for optimum treatment: audit of treatment of 408 cases. J Plast Reconstr Aesthet Surg 60:1030-5
7. Kranenburg O, Gebbink MF, Voest EE (2004) Stimulation of angiogenesis by Ras proteins. Biochim Biophys Acta 1654:23-37
8. Leon-Villapalos J, Wolfe K, Kangesu L (2005) GLUT-1: an extra diagnostic tool to differentiate between haemangiomas and vascular malformations. Br J Plast Surg 58:348-52
9. Meadows KN, Bryant P, Vincent PA et al. (2004) Activated Ras induces a proangiogenic phe-notype in primary endothelial cells. Oncogene 23:192-200
10. Morice-Picard F, Ezzedine K, Delrue MA et al. (2013) Cutaneous manifestations in Costello and cardio-faciocutaneous syndrome: report of 18 cases and literature review. Pediatr Dermatol 30:665-73
11. Palomba G, Colombino M, Contu A et al. (2012) Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia. J Transl Med 10:178
12. Reifenberger J, Knobbe CB, Sterzinger AA et al. (2004) Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. Int J Cancer 109:377-84
13. Tang B, Reardon W, Black GC et al. (2007) Congenital ulcerating hemangioma in a baby with KRAS mutation and cardio-facio-cutaneous syndrome. Clin Dysmorphol 16:203-6
14. Wine Lee L, Goff KL, Lam JM et al. (2014) Treatment of pediatric pyogenic granulomas using beta-adrenergic receptor antagonists. Pediatr Dermatol 31:203-7
15. Ye C, Pan L, Huang Y et al. (2011) Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations. J Vasc Surg 54:1760-8