Rapid quantitative D-dimer to exclude pulmonary embolism: A prospective cohort management study

Journal of Thrombosis and Haemostasis

Volumn 14, Issue 3, 2016, Pages 504-509

  Bates, S M ^a,b   Takach Lapner, S ^a   Douketis, J D ^a,b   Kearon, C ^a,b   Julian, J ^c   Parpia, S ^c   Schulman, S ^a,b   Weitz, J I ^a,b   Linkins, L A ^a,b   Crowther, M ^a,b   Lim, W ^a,b   Spencer, F A ^a,b   Lee, A Y Y ^d   Gross, P L ^a,b   Ginsberg, J ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c HAMILTON HEALTH SCIENCES   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

D dimer; Humans; Probability; Pulmonary embolism; Sensitivity and specificity; Venous thromboembolism

Indexed keywords

D DIMER; ANTICOAGULANT AGENT; BIOLOGICAL MARKER; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE MARKER; FEMALE; FOLLOW UP; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; VENOUS THROMBOEMBOLISM; AGED; BLOOD; CANADA; CLINICAL TRIAL; DRUG ADMINISTRATION; LATEX AGGLUTINATION TEST; MULTICENTER STUDY; PROGNOSIS; PULMONARY EMBOLISM; REPRODUCIBILITY; RISK FACTOR; TERTIARY CARE CENTER; TIME FACTOR;

ADULT; AGED; ANTICOAGULANTS; BIOMARKERS; CANADA; DRUG ADMINISTRATION SCHEDULE; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; LATEX FIXATION TESTS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; REPRODUCIBILITY OF RESULTS; RISK FACTORS; TERTIARY CARE CENTERS; TIME FACTORS; VENOUS THROMBOEMBOLISM;

EID: 84959935430     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13234     Document Type: Article

References (12)

1. Le Gal G, Bounameaux H. Diagnosing pulmonary embolism: running after the decreasing prevalence of cases among suspected patients. J Thromb Haemost 2004; 2: 1244-6.
2. Lucassen W, Geersing GJ, Erkens PM, Reitsma JB, Moons KG, Buller H, van Weert HC. Clinical decision rules for excluding pulmonary embolism: a meta-analysis. Ann Intern Med 2011; 155: 448-60.
3. Bates SM, Kearon C, Crowther M, Linkins L, O'Donnell M, Douketis J, Lee AY, Weitz JI, Johnston M, Ginsberg JS. A diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis. Ann Intern Med 2003; 138: 787-94.
4. Bates SM, Grand'Maison A, Johnston M, Naguit I, Kovacs MJ, Ginsberg JS. A latex D-dimer reliably excludes venous thromboembolism. Arch Intern Med 2001; 161: 447-53.
5. Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost 2000; 83: 416-20.
6. Hendriksen JM, Geersing GJ, Lucassen WA, Erkens PM, Stoffers HE, van Weert HC, Buller HR, Hoes AW, Moons KG. Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care. BMJ 2015; 351: h4438.
7. van Beek EJ, Brouwerst EM, Song B, Stein PD, Oudkerk M. Clinical validity of a normal pulmonary angiogram in patients with suspected pulmonary embolism - a critical review. Clin Radiol 2001; 56: 838-42.
8. van Belle A, Buller HR, Huisman MV, Huisman PM, Kaasjager K, Kamphuisen PW, Kramer MH, Kruip MJ, Kwakkel-van Erp JM, Leebeek FW, Nijkeuter M, Prins MH, Sohne M, Tick LW. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA 2006; 295: 172-9.
9. Perrier A, Desmarais S, Miron MJ, de Moerloose P, Lepage R, Slosman D, Didier D, Unger PF, Patenaude JV, Bounameaux H. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet 1999; 353: 190-5.
10. Douma RA, Mos IC, Erkens PM, Nizet TA, Durian MF, Hovens MM, van Houten AA, Hofstee HM, Klok FA, ten Cate H, Ullmann EF, Buller HR, Kamphuisen PW, Huisman MV; Prometheus Study Group. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study. Ann Intern Med 2011; 154: 709-18.
11. Anderson DR, Kahn SR, Rodger MA, Kovacs MJ, Morris T, Hirsch A, Lang E, Stiell I, Kovacs G, Dreyer J, Dennie C, Cartier Y, Barnes D, Burton E, Pleasance S, Skedgel C, O'Rouke K, Wells PS. Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA 2007; 298: 2743-53.
12. Kearon C, Ginsberg JS, Douketis J, Turpie AG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson DR, Kovacs MJ, Linkins LA, Julian JA, Bonilla LR, Gent M. An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial. Ann Intern Med 2006; 144: 812-21.