sTrehalose-6-phosphate synthase and stabilization of yeast glycolysis

FEMS Yeast Research

Volumn 16, Issue 1, 2016, Pages

  Fraenkel, Dan ^a   Nielsen, Jens ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c Chalmers University of Technology   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

TREHALOSE; TREHALOSE 6 PHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; GLUCOSYLTRANSFERASE; TREHALOSE-6-PHOSPHATE SYNTHASE;

ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SYNTHESIS; FUNGUS MUTANT; GLYCOLYSIS; MATHEMATICAL MODEL; NONHUMAN; NOTE; PROTEIN STABILITY; SIMULATION; STOICHIOMETRY; WILD TYPE; YEAST; BIOLOGICAL MODEL; METABOLIC FLUX ANALYSIS; METABOLISM; SACCHAROMYCES CEREVISIAE;

GLUCOSYLTRANSFERASES; GLYCOLYSIS; METABOLIC FLUX ANALYSIS; MODELS, BIOLOGICAL; SACCHAROMYCES CEREVISIAE;

EID: 84959891449     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1093/femsyr/fov100     Document Type: Note

References (22)

1. Dean ACR, Hinshelwood C. Growth, Function and Regulation in Bacterial Cells. London: Oxford University Press, 1966.
2. Elbein AD, Pan YT, Pastuszak I, et al. New insights on trehalose:a multifunctional molecule. Glycobiology 2003;13:17R-27R.
3. Gancedo G, Flores C-L. The importance of a functional trehalose biosynthetic pathway for the life of yeasts and fungi. FEMS Yeast Res 2004;4:351-9.
4. Harden A. Alcoholic Fermentation. London: Longmans, Green & Co., 1923, 54.
5. Kotte O, Volkmer B, Radzikowski JL, et al. Phenotypic biastability in Escherichia coli's central carbon metabolism. Molec Syst Biol 2014;10:736.
6. Mulakutia BC, Yongky A, Daoutidis P, et al. Bistability in glycolysis pathway as a physiological switch in energy metabolism. PLoS One 2014;9:e98756.
7. Navon G, Shulman RG, Yamane T, et al. Phosphorus-31 nuclear magnetic resonance studies of wild-type and glycolytic pathway mutants of Saccharomyces cerevisiae. Biochemistry 1979;18:4487-99.
8. Paul MJ, Primavesi LF, Jhurreea D, et al. Trehalose metabolism and signaling. Ann Rev Plant Biol 2008;59:417-41.
9. Petitjean M, Teste M-A, Francois JM, et al. Yeast tolerance to various stresses relies on the trehalose-6P synthase (Tps1) protein, not on trehalose. J Biol Chem 2015;290:16177-90.
10. Petitjean M, Vax A, Teste MA, et al. Revisiting the role of TPS1 encoding trehalose 6-P synthase in the regulation of yeast glycolysis. 94A in Abstract Book, Yeast Genetics Meeting, Seattle 4014, Genetics Society of America, 2014.
11. Planque R, Bruggeman FJ, Teusink B, et al. Understanding bistability in yeast glycolysis using general properties of metabolic pathways. Math Biosci 2014;255:33-42.
12. Shi L, Sutter BM, Ye X, et al. Trehalose is a key determinant of the quiescent metabolic state that fuels cell cycle progression upon return to growth. Mol Biol Cell 2010;21:1982-90.
13. Teusink B, Passarge J, Reijenga CA, et al. Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem 2000;267:5313-29.
14. Theobald U, Mailinger W, Baltes M, et al. In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae: I. Experimental observations. Biotechnol Bioeng 1997;55:305-16.
15. Theobald U, Mohns J, Rizzi M. Determination of in vivo cytoplasmic orthophosphate concentration in yeast. Biotechnol Tech 1996;10:297-302.
16. Thevelein JH, Hohmann S. Trehalose synthase: guard to the gate of glycolysis in yeast? TIBS 1995;20:3-10.
17. van de Poll K, Kerkenaar A, Schamhart DHJ. Isolation of a regulatory mutant of fructose-1,6-diphosphatase in Saccharomyces carlsbergensis. J Bacteriol 1974;117:965-70.
18. van Eunen K, Kiewiet JAL, Westerhoff HV, et al. Testing Biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics. PLoS Comput Biol 2012;8:e1002483.
19. van Heerden JH, Wortel MT, Bruggeman FJ, et al. Lost in transition:start-up of glycolysis yields subpopulations of nongrowing cells. Science 2014;343:987.
20. Walther T, Mtimet N, Alkim C, et al. Metabolic phenotypes of Saccharomyces cerevisiae mutants with altered trehalose 6- phosphate dynamics. Biochem J 2013;454:227-37.
21. Westenholme GEW, O'Conner CM (eds). CIBA Foundation Symposium on Drug Resistance in Micro-organisms. Mechanisms of Development. Boston: Little, Brown and Co., 1957.
22. Wilson RA, Jenkinson JM, Gibson RP, et al. Tps1 regulates the pentose phosphate pathway, nitrogen metabolism and fungal virulence. EMBO J 2007;26:3673-85.