Association between Response to Etrolizumab and Expression of Integrin αe and Granzyme A in Colon Biopsies of Patients with Ulcerative Colitis

Gastroenterology

Volumn 150, Issue 2, 2016, Pages 477-487.e9

  Tew, Gaik W ^a   Hackney, Jason A ^a   Gibbons, Deena ^b   Lamb, Christopher A ^c   Luca, Diana ^a   Egen, Jackson G ^a   Diehl, Lauri ^a   Eastham Anderson, Jeff ^a   Vermeire, Severine ^d   Mansfield, John C ^c   Feagan, Brian G ^e   Panes, Julian ^f   Baumgart, Daniel C ^g   Schreiber, Stefan ^h   Dotan, Iris ⁱ   Sandborn, William J ^j   Kirby, John A ^c   Irving, Peter M ^b   De Hertogh, Gert ^d   Van Assche, Gert A ^d,k   Rutgeerts, Paul ^d   O'Byrne, Sharon ^a   Hayday, Adrian ^b   Keir, Mary E ^a   more..

^a GENENTECH INC   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF WESTERN ONTARIO   (Canada)

^f HOSPITAL CLÍNIC   (Spain)

^g HUMBOLDT UNIVERSITY   (Germany)

^h UNIVERSITY OF KIEL   (Germany)

ⁱ TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k UNIVERSITY OF TORONTO   (Canada)

more..

Author keywords

Anti Integrin; IBD Drug; Personalized Medicine; Response to Therapy

Indexed keywords

ALPHA INTEGRIN; ALPHAE INTEGRIN; CARBON TETRACHLORIDE; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE A2; CD161 ANTIGEN; CHEMOKINE RECEPTOR CXCR7; CXCL1 CHEMOKINE; ENOYL COENZYME A HYDRATASE; ENOYL COENZYME A HYDRATASE 1; ETROLIZUMAB; FAM125B PROTEIN; FAS LIGAND; FIBROBLAST GROWTH FACTOR 9; FORKHEAD TRANSCRIPTION FACTOR; GRANZYME A; GRANZYME B; INTERLEUKIN 17F; INTERLEUKIN 8; LEUCINE RICH REPEAT CONTAINING 4 PROTEIN; MESSENGER RNA; PERFORIN; PHF14 PROTEIN; PROTEIN; TMIGD2 PROTEIN; TRANSCRIPTION FACTOR FOXM1; TRANSMEMBRANE PROTEIN 154; TRANSMEMBRANE PROTEIN 200A; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG; VNN2 PROTEIN; ALPHA E INTEGRINS; ANTIINFLAMMATORY AGENT; GASTROINTESTINAL AGENT; GRANZYME; GZMA PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL FEATURE; COLON; COLON BIOPSY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTE; MONONUCLEAR CELL; PHASE 2 CLINICAL TRIAL (TOPIC); PREDICTIVE VALUE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; RETROSPECTIVE STUDY; SCORING SYSTEM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TISSUE LEVEL; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; ULCERATIVE COLITIS; UPREGULATION; BIOPSY; COLITIS, ULCERATIVE; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PROCEDURES; TIME FACTOR; WOUND HEALING;

ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, CD; BIOPSY; CLINICAL TRIALS, PHASE II AS TOPIC; COLITIS, ULCERATIVE; COLON; GASTROINTESTINAL AGENTS; GENE EXPRESSION PROFILING; GRANZYMES; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA CHAINS; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REMISSION INDUCTION; RETROSPECTIVE STUDIES; RNA, MESSENGER; TIME FACTORS; TREATMENT OUTCOME; WOUND HEALING;

EID: 84959576380     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.10.041     Document Type: Article

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