Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): A randomised controlled trial

The Lancet

Volumn 387, Issue 10029, 2016, Pages 1732-1742

  Gilbert, Ruth E ^a   Mok, Quen ^b   Dwan, Kerry ^c   Harron, Katie ^a   Moitt, Tracy ^c   Millar, Mike ^d   Ramnarayan, Padmanabhan ^b   Tibby, Shane M ^e   Hughes, Dyfrig ^f   Gamble, Carrol ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d BARTS HEALTH NHS TRUST   (United Kingdom)

^e ST THOMAS HOSPITAL   (United Kingdom)

^f BANGOR UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; HEPARIN; MINOCYCLINE; RIFAMPICIN; ANTIINFECTIVE AGENT; FIBRINOLYTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BLOODSTREAM INFECTION; CATHETER INFECTION; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; CHILD; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; FEMALE; HUMAN; INFANT; INFECTION PREVENTION; INTENSIVE CARE UNIT; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NONHUMAN; PATIENT SAFETY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ADOLESCENT; BACTEREMIA; CANDIDEMIA; CATHETER-RELATED INFECTIONS; CENTRAL VENOUS CATHETERIZATION; PRESCHOOL CHILD; PROCEDURES;

ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTEREMIA; CANDIDEMIA; CATHETER-RELATED INFECTIONS; CATHETERIZATION, CENTRAL VENOUS; CENTRAL VENOUS CATHETERS; CHILD; CHILD, PRESCHOOL; FEMALE; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; INFANT; MALE; MINOCYCLINE; RIFAMPIN;

EID: 84959558308     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)00340-8     Document Type: Article

References (31)

1. R Abou Elella, H Najm, H Balkhy, L Bullard, M Kabbani Impact of bloodstream infection on the outcome of children undergoing cardiac surgery Pediatr Cardiol 31 2010 483 489
2. AM Elward, CS Hollenbeak, DK Warren, VJ Fraser Attributable cost of nosocomial primary bloodstream infection in pediatric intensive care unit patients Pediatrics 115 2005 868 872
3. A Bhutta, C Gilliam, M Honeycutt et al. Reduction of bloodstream infections associated with catheters in paediatric intensive care unit: stepwise approach BMJ 334 2007 362 365
4. P Pronovost, D Needham, S Berenholtz et al. An intervention to decrease catheter-related bloodstream infections in the ICU N Engl J Med 355 2006 2725 2732
5. MR Miller, M Griswold, JM Harris II et al. Decreasing PICU catheter-associated bloodstream infections: NACHRI's quality transformation efforts Pediatrics 125 2010 206 213
6. J Bion, A Richardson, P Hibbert et al. 'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England BMJ Qual Saf 22 2012 110 123
7. Department of Health Saving Lives: reducing infection, delivering clean and safe care 2007 Department of Health London
8. HM Treasury Pre-budget report and comprehensive spending review 2007 Stationery Office London
9. NP O'Grady, M Alexander, LA Burns et al. Guidelines for the prevention of intravascular catheter-related infections Clin Infect Dis 52 2011 e162 e193
10. K Harron, G Ramachandra, Q Mok, R Gilbert Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units Intensive Care Med 37 2011 1641 1647
11. R Gilbert, M Harden Effectiveness of impregnated central venous catheters for catheter related blood stream infection: a systematic review Curr Opin Infect Dis 21 2008 235 245
12. J Hockenhull, K Dwan, A Boland et al. The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation Health Technol Asses 12 2008 1 154
13. NM Lai, N Chaiyakunapruk, NA Lai, E O'Riordan, WSC Pau, S Saint Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults Cochrane Database Syst Rev 6 2013 CD007878
14. H Wang, T Huang, J Jing et al. Effectiveness of different central venous catheters for catheter-related infections: a network meta-analysis J Hosp Infect 76 2010 1 11
15. PS Shah, N Shah Heparin-bonded catheters for prolonging the patency of central venous catheters in children Cochrane Database Syst Rev 17 2014 CD005983
16. C Geffers, I Zuschneid, T Eckmanns, H Rüden, P Gastmeier The relationship between methodological trial quality and the effects of impregnated central venous catheters Intensive Care Med 29 2003 403 409
17. LA Mermel, SM Stolz, DG Maki Surface antimicrobial activity of heparin-bonded and antiseptic-impregnated vascular catheters J Infect Dis 167 1993 920 924
18. K Harron, R Parslow, Q Mok et al. Monitoring quality of care through linkage of administrative data: national trends in bloodstream infection in UK paediatric intensive care units 2003-2012 Crit Care Med 43 2015 1070 1078
19. CM Pierce, A Wade, Q Mok Heparin-bonded central venous lines reduce thrombotic and infective complications in critically ill children Intensive Care Med 26 2000 967 972
20. EG Cox, CA Knoderer, A Jennings et al. A randomized, controlled trial of catheter-related infectious event rates using antibiotic-impregnated catheters versus conventional catheters in pediatric cardiovascular surgery patients J Pediatr Infect Dis 2 2013 67 70
21. A Abdelkefi, W Achour, T Ben Othman et al. Use of heparin-coated central venous lines to prevent catheter-related bloodstream infection J Support Oncol 5 2007 273 278
22. Universities of Leeds and Leicester Paediatric Intensive Care Audit Network national report 2011-2013 2013 University of Leeds Leeds
23. A Slater, F Shann, G Pearson PIM2: a revised version of the Paediatric Index of Mortality Intensive Care Med 29 2003 278 285
24. Cook Incorporated Cook Spectrum® Central Venous Catheter Minocycline/Rifampin ANtibiotic Impregnated Power Injectable. Instructions for use https://www.cookmedical.com/data/IFU-PDF/C-T-CTULMABRM-REV3.PDF (accessed Jan 23, 2016).
25. I Raad, H Hanna, D Maki Intravascular catheter-related infections: advances in diagnosis, prevention, and management Lancet Infect Dis 7 2007 645 657
26. RJ Gray A class of K-sample tests for comparing the cumulative incidence of a competing risk Ann Stat 16 1988 1141 1154
27. K Harron, K Woolfall, C Gamble, Q Mok, P Ramnarayan, R Gilbert Deferred consent for randomised controlled trials in emergency paediatric care settings: evidence for trial design and ethics committees Pediatrics 136 2015 e1316 e1322
28. Harron K, Mok Q, Dwan K, et al. Catheter infections in children (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children. Health Technol Assess (in press).
29. K Harron, Q Mok, R Parslow, B Muller-Pebody, R Gilbert, P Ramnarayan Risk of bloodstream infection in children admitted to paediatric intensive care units in England and Wales following emergency inter-hospital transfer Intensive Care Med 40 2014 1916 1923
30. ME Falagas, K Fragoulis, IA Bliziotis, I Chatzinikolaou Rifampicin-impregnated central venous catheters: a meta-analysis of randomized controlled trials J Antimicrob Chemother 59 2007 359 369
31. K Harron, A Wade, B Muller-Pebody et al. Risk-adjusted monitoring of blood-stream infection in paediatric intensive care: a data linkage study Intensive Care Med 39 2013 1080 1087