Tumor regression and allograft rejection after administration of anti-PD-1

New England Journal of Medicine

Volumn 374, Issue 9, 2016, Pages 896-898

  Lipson, Evan J ^a   Bagnasco, Serena M ^a   Moore, Jack ^b   Jang, Sekwon ^c   Patel, Manisha J ^a   Zachary, Andrea A ^a   Pardoll, Drew M ^a   Taube, Janis M ^a   Drake, Charles G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^c Inova Dwight and Martha Schar Cancer Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CETUXIMAB; COMPLEMENT COMPONENT C4D; CYCLOSPORIN; GLUCOCORTICOID; KI 67 ANTIGEN; PEMBROLIZUMAB; PREDNISONE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; TRAMETINIB; ANTINEOPLASTIC AGENT; PDCD1 PROTEIN, HUMAN;

ACUTE GRAFT REJECTION; ADULT; CASE REPORT; CHRONIC GRAFT REJECTION; COMPUTER ASSISTED TOMOGRAPHY; CYTOTOXIC T LYMPHOCYTE; DRUG DOSE REDUCTION; DRUG MEGADOSE; FEMALE; HEMODIALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LETTER; LOSS OF FUNCTION MUTATION; MIDDLE AGED; PRIORITY JOURNAL; SKIN CARCINOMA; TUMOR REGRESSION; ALLOGRAFT; ANTAGONISTS AND INHIBITORS; CARCINOMA, SQUAMOUS CELL; CHEMICALLY INDUCED; GRAFT REJECTION; IMMUNOCOMPROMIZED PATIENT; IMMUNOLOGY; KIDNEY; METABOLISM; PATHOLOGY; SECONDARY; SKIN NEOPLASMS;

ALLOGRAFTS; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOCOMPROMISED HOST; KIDNEY; KIDNEY TRANSPLANTATION; MIDDLE AGED; PROGRAMMED CELL DEATH 1 RECEPTOR; SKIN NEOPLASMS;

EID: 84959542243     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1509268     Document Type: Letter

References (5)

1. Lipson EJ, Forde PM, Hammers HJ, Emens LA, Taube JM, Topalian SL. Antagonists of PD-1 and PD-L1 in cancer treatment. Semin Oncol 2015; 42: 587-600.
2. Brunner M, Veness MJ, Ch'ng S, Elliott M, Clark JR. Distant metastases from cutaneous squamous cell carcinoma-analysis of AJCC stage I V. Head Neck 2013; 35: 72-5.
3. Wang CQ, Yanofsky VR, Mitsui H, Krueger JG, Felsen D, Carucci JA. The PD-1 pathway is a potential drug target for squa-mous cell carcinoma in solid organ transplant recipients. J Invest Dermatol 2013; 133: Suppl 1: S10. abstract.
4. Teply BA, Lipson EJ. Identification and management of toxicities from immune checkpoint-blocking drugs. Oncology (Williston Park) 2014;28:Suppl 3:30-8.
5. Lipson EJ, Bodell MA, Kraus ES, Sharfman WH. Successful administration of ipilimumab to two kidney transplantation patients with metastatic melanoma. J Clin Oncol 2014; 32(19): e69-71.