High Frequency of Detection by PCR of Viral Nucleic Acid in The Blood of Infants Presenting with Clinical Myocarditis

Pediatric Cardiology

Volumn 37, Issue 2, 2016, Pages 399-404

  Simpson, Kathleen E ^a   Storch, Gregory A ^a   Lee, Caroline K ^a   Ward, Kent E ^b   Danon, Saar ^c   Simon, Catherine M ^d   Delaney, Jeffrey W ^e   Tong, Alan ^f   Canter, Charles E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f Mednax National Medical Group   (United States)

Author keywords

DNAemia; Myocarditis; Pediatric cardiology

Indexed keywords

VIRUS DNA;

ADENOVIRIDAE; AGE DISTRIBUTION; ARTICLE; BLOOD CULTURE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CONVALESCENCE; DIAGNOSTIC TEST ACCURACY STUDY; ENTEROVIRUS; FEMALE; FOLLOW UP; HEART TRANSPLANTATION; HUMAN; HUMAN HERPESVIRUS 6; HUMAN PARVOVIRUS B19; INFANT; MALE; OBSERVATIONAL STUDY; PEDIATRIC CARDIOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; VIRUS CELL INTERACTION; VIRUS CULTURE; VIRUS DETECTION; VIRUS INFECTIVITY; VIRUS MYOCARDITIS; BLOOD; CASE CONTROL STUDY; CHILD; CLINICAL TRIAL; HEART; ISOLATION AND PURIFICATION; MULTICENTER STUDY; MYOCARDITIS; PRESCHOOL CHILD; UNITED STATES; VIROLOGY;

ADENOVIRIDAE; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; ENTEROVIRUS; FEMALE; HEART; HEART TRANSPLANTATION; HERPESVIRUS 6, HUMAN; HUMANS; INFANT; MALE; MYOCARDITIS; PARVOVIRUS B19, HUMAN; POLYMERASE CHAIN REACTION; UNITED STATES;

EID: 84959524428     PISSN: 01720643     EISSN: 14321971     Source Type: Journal    
DOI: 10.1007/s00246-015-1290-6     Document Type: Article

References (17)

1. Andrews RE et al (2008) New-onset heart failure due to heart muscle disease in childhood: a prospective study in the United kingdom and Ireland. Circulation 117(1):79–84
2. Bauer S et al (2002) Severe Coxsackie virus B infection in preterm newborns treated with pleconaril. Eur J Pediatr 161(9):491–493
3. Colvin JM et al (2012) Detection of viruses in young children with fever without an apparent source. Pediatrics 130(6):e1455–e1462
4. Cooper LT Jr (2009) Myocarditis. N Engl J Med 360(15):1526–1538
5. Daliento L et al (2003) Successful treatment of enterovirus-induced myocarditis with interferon-alpha. J Heart Lung Transplant 22(2):214–217
6. Daubeney PE et al (2006) Clinical features and outcomes of childhood dilated cardiomyopathy: results from a national population-based study. Circulation 114(24):2671–2678
7. Durani Y et al (2009) Pediatric myocarditis: presenting clinical characteristics. Am J Emerg Med 27(8):942–947
8. Florescu DF, Keck MA (2014) Development of CMX001 (Brincidofovir) for the treatment of serious diseases or conditions caused by dsDNA viruses. Expert Rev Anti Infect Ther 12(10):1171–1178
9. Florescu DF et al (2012) Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients. Biol Blood Marrow Transplant 18(5):731–738
10. Heim A et al (1996) Recombinant interferons beta and gamma have a higher antiviral activity than interferon-alpha in coxsackievirus B3-infected carrier state cultures of human myocardial fibroblasts. J Interferon Cytokine Res 16(4):283–287
11. Kuhl U et al (2003) Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation 107(22):2793–2798
12. Lim BK et al (2015) Soluble coxsackievirus B3 3C protease inhibitor prevents cardiomyopathy in an experimental chronic myocarditis murine model. Virus Res 199:1–8
13. Lipshultz SE et al (2003) The incidence of pediatric cardiomyopathy in two regions of the United States. N Engl J Med 348(17):1647–1655
14. Pevear DC et al (1999) Activity of pleconaril against enteroviruses. Antimicrob Agents Chemother 43(9):2109–2115
15. Rotbart HA, Webster AD, Pleconaril G (2001) Treatment registry, treatment of potentially life-threatening enterovirus infections with pleconaril. Clin Infect Dis 32(2):228–235
16. Towbin JA et al (2006) Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 296(15):1867–1876
17. Yun SH et al (2012) Antiviral activity of coxsackievirus B3 3C protease inhibitor in experimental murine myocarditis. J Infect Dis 205(3):491–497