Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

Journal of Nutrition, Health and Aging

Volumn 20, Issue 3, 2016, Pages 325-333

  Fulton, R L ^a   McMurdo, M E T ^a   Hill, A ^d   Abboud, R J ^b   Arnold, G P ^b   Struthers, A D ^a   Khan, F ^a   Vermeer, C ^c   Knapen, M H J ^c   Drummen, N E A ^c   Witham, M D ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d NONE

Author keywords

flow mediated dilatation; older people; physical function; vascular health; Vitamin K

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CHOLESTEROL; FARNOQUINONE; OSTEOCALCIN; PLACEBO; BIOLOGICAL MARKER; VITAMIN K GROUP;

AGED; ARTERIAL WALL THICKNESS; ARTERY DILATATION; ARTICLE; AUGMENTATION INDEX; BLOOD PRESSURE; BODY EQUILIBRIUM; BRACHIAL ARTERY; CAROTID ARTERY PULSE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HAND STRENGTH; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; VASCULAR DISEASE; VITAMIN SUPPLEMENTATION; BLOOD; DIET THERAPY; DIETARY SUPPLEMENT; DRUG EFFECTS; PATHOPHYSIOLOGY; PHYSIOLOGY; PULSE WAVE; TREATMENT FAILURE;

AGED; BIOMARKERS; BLOOD PRESSURE; BRACHIAL ARTERY; C-REACTIVE PROTEIN; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HAND STRENGTH; HUMANS; MALE; NATRIURETIC PEPTIDE, BRAIN; PULSE WAVE ANALYSIS; TREATMENT FAILURE; VASCULAR DISEASES; VITAMIN K;

EID: 84959507531     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-015-0619-4     Document Type: Article

References (30)

1. Thane CW, Bates CJ, Shearer MJ, Unadkat N, Harrington DJ, Paul AA, Prentice A, Bolton-Smith C. Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people. Br J Nutr 2002;876:615–22.
2. Gast GCM, de Roos NM, Sluijs I, Bots ML, Beulens JWJ, Geleijnse JM, Witteman JC, Grobbee DE, Peeters PH, van der Schouw YT. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 2009;197:504–10.
3. Shea MK, Booth SL, Massaro JM, Jacques PF, D’Agostino RB, Sr., Dawson-Hughes B, Ordovas JM, O’Donnell CJ, Kathiresan S, Keaney JF Jr, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol 2008;1673:313–20.
4. van den Heuvel EGHM, van Schoor NM, Lips P, Magdeleyns EJP, Deeg DJH, Vermeer C, den Heijer M. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk of cardiovascular disease. Maturitas 2014;772:137–41.
5. Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WMM, Boer JMA, Beulens JWJ. Matrix Gla protein species and risk of cardiovascular events in type 2 diabetic patients. Diabetes Care 2013;3611:3766–71.
6. Schlieper G, Westenfeld R, Krüger T, Cranenburg EC, Magdeleyns EJ, Brandenburg VM, Djuric Z, Damjanovic T, Ketteler M, Vermeer C, et al. Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD. J Am Soc Nephrol 2011:22(2);387–95.
7. Kaesler N, Schettgen T, Mutucumarana VP, Brandenburg V, Jahnen-Dechent W, Schurgers LJ, Kruger T. A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity. Anal Biochem 2012;4212:411–6.
8. Braam LAJLM, Hoeks APG, Brouns F, Hamulyak K, Gerichhausen MJW, Vermeer C. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost 2004;2:372–80.
9. Kamper AM, Stott DJ, Hyland M, Murray HM, Ford I. Predictors of functional decline in elderly people with vascular risk factors or disease. Age Ageing 2005;34:450–5.
10. Cheung AM, Tile L, Lee Y, Tomlinson G, Hawker G, Scher J, Hu H, Vieth R, Thompson R, Jamal S, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. PLoS Med 2008;5(10):e196.
11. Dalmeijer GW, van der Schouw YT, Magdeleyns E, Ahmed N, Vermeer C, Beulens JW. The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis 2012;225:397–402.
12. Westenfeld R, Krueger T, Schlieper G, Cranenburg ECM, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in haemodialysis patients: a randomised controlled trial. Am J Kidney Dis 2012;592:186–95.
13. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer DS, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, et al. Guidelines for the ultrasound Assessment of Endothelial-Dependent Vasodilation of the Brachial Artery. J Am Coll Cardiol 2002;2:257–65.
14. Naka KN, Papathanassiou K, Bechlioulis A, Kazakos N, Pappas K, Tigas S, Makriyiannis D, Tsatsoulis A, Michalis LK. Determinants of vascular function in patients with type 2 diabetes. Cardiovasc Diabetol 2012; 11:127.
15. Perticone F, Ceravolo R, Pujia A, Ventura G, Iacopino S, Scozzafava A, Ferraro A, Chello M, Mastroroberto P, Verdecchia P, et al. Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients. Circulation 2001;104:191–6.
16. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111–5.
17. Cranenburg ECM, Koos R, Schurgers LJ, Magdeleyns EJ, Schoonbrood THM, Landewe RB, Brandenburg VM, Bekers O, Vermeer C. Characterization and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemostas 2010;104:811–22.
18. Gawel J, Vengrow D, Collins J, Brown S, Buchanan A, Cook C. The short performance battery as a predictor for long term disability or institutionalization in the community dwelling population aged 65 years old or older. Phys Ther Rev 2012;171:37–44.
19. Decker LM, Ramdani S, Tallon G, Jaussent A, Picot MC, Bernard PL, et al. Physical function decline and degradation of postural sway dynamics in asymptomatic sedentary postmenopausal women. J Nutr Health Aging. 2015;193:348–55.
20. Pavol, MJ. Detecting and Understanding Differences in Postural Sway. Focus on A New Interpretation of Spontaneous Sway Measures Based on a Simple Model of Human Postural Control. J Neurophysiol 2005;93:20–1.
21. Moriguch, J, Itoh, H, Harada, S, Takeda, K, Hatta, T, Nakata, T, Sasaki, S. Low Frequency Regular Exercise Improves Flow-Mediated Dilatation of Subjects with Mild Hypertension. Hypertens Res 2005;28:315–21.
22. Dogra, GK, Watts GF, Herrmann, S, Thomas MAB, Irish AB. Statin therapy improves brachial artery endothelial function in nephrotic syndrome. Kidney Int 2002;62:550–7.
23. Kaesler N, Magdeleyns E, Herfs M, Schettgen T, Brandenburg V, Fliser D et al. Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int. 2014;86:286–93.
24. Health & Consumer Protection Directorate General. European Commission. Discussion Paper on the setting of maximum and minimum amounts for vitamins and minerals in foodstuffs. June 2006; 1–27.
25. Blankenhorn DH, Kramsch DM, Azen SP, Mack WJ, Cashin-Hemphill L, Hodis HN, De Boer LW, Mahrer PR, Masteller MJ, Vailas LI, et al. Coronary Angiographic Changes with Lovastatin Therapy: The Monitored Artherosclerosis Regression study (MARS). Ann Intern Med 1993;119:969–76.
26. George J, Carr E, Davis J, Belch JJF, Struthers AD. High dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid. Circulation 2006;114:2508–16.
27. Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels. Diabet Med 2008;253:320–5.
28. Buurman BM, van Munster BC, Korevaar JC, Abu-Hanna A, Levi M, de Rooij SE. Prognostication in acutely admitted older patients by nurses and physicians. J Gen Int Med 2008;23:1883–9.
29. Dorner TE, Luger E, Tschinderle J, Stein KV, Haider S, Kapan A, et al. Association between nutritional status (MNA(R)-SF) and frailty (SHARE-FI) in acute hospitalised elderly patients. J Nutr, Health Aging 2014;18:264–9.
30. Matzen LE, Jepsen DB, Ryg J, Masud T. Functional level at admission is a predictor of survival in older patients admitted to an acute geriatric unit. BMC geriatrics 2012;12:32.