Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

Diabetologia

Volumn 59, Issue 4, 2016, Pages 734-743

  Rakshit, Kuntol ^a,b   Hsu, Tu Wen ^b   Matveyenko, Aleksey V ^a,b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Beta cell; Beta cell expansion; Beta cell failure; BMAL1; Circadian clock; Clock genes; High fat diet

Indexed keywords

TAMOXIFEN; ARNTL PROTEIN, MOUSE; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BMAL1 GENE; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIET INDUCED OBESITY; DIET RESTRICTION; GENE; GENE DELETION; GENETIC RECOMBINATION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; ADVERSE EFFECTS; ANIMAL; CYTOLOGY; FEMALE; GENETICS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSIOLOGY;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; CELL SURVIVAL; CIRCADIAN RHYTHM; CLOCK PROTEINS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FEMALE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MALE; MICE; OBESITY;

EID: 84959479091     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3859-2     Document Type: Article

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