B cells shed light on diminished vaccine responses in obesity

Obesity

Volumn 24, Issue 3, 2016, Pages 551-

  Nicholas, Dequina A ^a,b   Nikolajczyk, Barbara S ^a  

^a Department of Microbiology ^*  (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; TUMOR NECROSIS FACTOR ALPHA; VACCINE;

ANTIBODY PRODUCTION; ANTIBODY TITER; B LYMPHOCYTE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INFLUENZA; MEMORY CELL; NOTE; OBESITY; PATHOGEN CLEARANCE; VACCINATION; IMMUNOLOGY;

B-LYMPHOCYTES; HUMANS; OBESITY; VACCINES;

EID: 84959463122     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21429     Document Type: Note

References (6)

1. Sheridan PA, Paich HA, Handy J, et al., Obesity is associated with impaired immune response to influenza vaccination in humans. Int J Obes (Lond) 2012; 36: 1072-1077.
2. Young KM, Gray CM, Bekker LG., Is obesity a risk factor for vaccine non-responsiveness? PLoS One 2013; 8: e82779.
3. Defuria J, Belkina AC, Jagannathan-Bogdan M, et al., B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci USA 2013; 110: 5133-5138.
4. Frasca D, Ferracci F, Diaz A, Romero M, Lechner S, Blomberg BB,. Obesity decreases B cell responses in young and elderly individuals. Obesity 2016; 24: 615-625.
5. Frasca D, Diaz A, Romero M, Landin AM, Blomberg BB., High TNF-alpha levels in resting B cells negatively correlate with their response. Exp Gerontol 2014; 54: 116-122.
6. Sheridan PA, Paich HA, Handy J, et al., The antibody response to influenza vaccination is not impaired in type 2 diabetics. Vaccine 2015; 33: 3306-3313.