The Revised (2013) Banff Classification for Antibody-Mediated Rejection of Renal Allografts: Update, Difficulties, and Future Considerations

American Journal of Transplantation

Volumn 16, Issue 5, 2016, Pages 1352-1357

  Haas, M ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q ANTIBODY; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C4D; CREATININE; HLA DP ANTIGEN; IMMUNOGLOBULIN G ANTIBODY; ALLOANTIBODY;

ACUTE GRAFT REJECTION; ANTIBODY MEDIATED REJECTION; ANTIGEN BINDING; BANFF CLASSIFICATION; CAPILLARITIS; CHRONIC GRAFT REJECTION; COMPLEMENT DEPOSITION; CREATININE BLOOD LEVEL; DISEASE CLASSIFICATION; DISEASE MARKER; GLOMERULITIS; GRAFT SURVIVAL; HUMAN; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; PRIORITY JOURNAL; PUBLICATION; REPRODUCIBILITY; REVIEW; CLASSIFICATION; GRAFT REJECTION; IMMUNOLOGY;

GRAFT REJECTION; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION;

EID: 84959440372     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13661     Document Type: Review

References (43)

1. Solez K, Axelsen RA, Benediktsson H, et al., International standardization of criteria for the histologic diagnosis of renal allograft rejection: The Banff working classification of kidney transplant pathology. Kidney Int 1993; 44: 411-422.
2. Halloran PF, Wadgymar A, Ritchie S, et al., The significance of the anti-class I antibody response. I. Clinical and pathologic features of anti-class I-mediated rejection. Transplantation 1990; 49: 85-91.
3. Halloran PF, Schlaut J, Solez K, Srinivasa NS,. The significance of the anti-class I response. II. Clinical and pathologic features of renal transplants with anti-class I-like antibody. Transplantation 1992; 53: 550-555.
4. Trpkov K, Campbell P, Pazderka F, Cockfield S, Solez K, Halloran PF,. Pathologic features of acute renal allograft rejection associated with donor-specific antibody. Transplantation 1996; 61: 1586-1592.
5. Collins AB, Schneeberger EE, Pascual MA, et al., Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208-2214.
6. Mauiyyedi S, Crespo M, Collins AB, et al., Acute humoral rejection in renal allograft recipients: II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol 2002; 13: 779-787.
7. Böhmig GA, Exner M, Habicht A, et al., Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002; 13: 1091-1099.
8. Koo DD, Roberts IS, Quiroga I, et al., C4d deposition in early renal allograft protocol biopsies. Transplantation 2004; 78: 398-403.
9. Nickeleit V, Zeiler M, Gudat F, et al., Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242-251.
10. Regele H, Exner M, Watschinger B, et al., Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001; 16: 2058-2066.
11. Montgomery RA, Zachary AA, Racusen LC, et al., Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients. Transplantation 2000; 70: 887-895.
12. Tanabe K, Takahashi K, Sonda S, et al., Clinicopathological analysis of rejection episodes in ABO incompatible kidney transplantation. Transplant Proc 1996; 28: 1447-1448.
13. Magil AB, Tinckam K,. Monocytes and peritubular capillary C4d deposition in acute renal allograft rejection. Kidney Int 2003; 63: 1888-1893.
14. Gloor JM, Cosio FG, Rea DJ, et al., Histologic findings one year after positive crossmatch or ABO blood group incompatible living donor kidney transplantation. Am J Transplant 2006; 6: 1841-1847.
15. Haas M, Rahman MH, Racusen LC, et al., C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: Correlation with histologic findings. Am J Transplant 2006; 6: 1829-1840.
16. Feucht HE, Schneeberger H, Hillebrand G, et al., Capillary deposition of C4d complement fragment and early renal graft loss. Kidney Int 1993; 43: 1333-1338.
17. Regele H, Böhmig GA, Habicht A, et al., Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 2002; 13: 2371-2380.
18. Mauiyyedi S, Pelle PD, Saidman S, et al., Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001; 12: 574-582.
19. Horita S, Nitta K, Kawashima M, et al., C4d deposition in the glomeruli and peritubular capillaries associated with transplant glomerulopathy. Clin Transplant 2003; 17: 325-330.
20. Gloor JM, Sethi S, Stegall MD, et al., Transplant glomerulopathy: Subclinical incidence and association with alloantibody. Am J Transplant 2007; 7: 2124-2132.
21. Sis B, Campbell PM, Mueller T, et al., Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause. Am J Transplant 2007; 7: 1743-1752.
22. Hill GS, Nochy D, Bruneval P, et al., Donor-specific antibodies accelerate arteriosclerosis after renal transplantation. J Am Soc Nephrol 2011; 22: 975-983.
23. Racusen LC, Colvin RB, Solez K, et al., Antibody-mediated rejection criteria-an addition to the Banff '97 classification of renal allograft rejection. Am J Transplant 2003; 3: 1-7.
24. Solez K, Colvin RB, Racusen LC, et al., Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008; 8: 753-760.
25. Sis B, Jhangri G, Bunnag S, Allanach K, Kaplan B, Halloran PF,. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am J Transplant 2009; 9: 2312-2323.
26. Loupy A, Suberbielle-Boissel C, Hill GS, et al., Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies. Am J Transplant 2009; 9: 2561-2570.
27. Lefaucheur C, Loupy A, Vernerey D, et al., Antibody-mediated vascular rejection of kidney allografts: A population-based study. Lancet 2013; 381: 313-319.
28. Haas M, Sis B, Racusen LC, et al., Banff 2013 meeting report: Inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant 2014; 14: 272-283.
29. Seemayer CA, Gaspert A, Nickeleit V, Mihatsch MJ,. C4d staining of renal allograft biopsies: A comparative analysis of different staining techniques. Nephrol Dial Transplant 2007; 22: 568-576.
30. Setoguchi K, Ishida H, Shimmura H, et al., Analysis of renal transplant protocol biopsies in ABO-incompatible renal transplantation. Am J Transplant 2008; 8: 86-94.
31. DeSerres S, Noel R, Cote I, et al., Banff criteria for chronic active antibody-mediated rejection: Assessment in a real life setting. Am J Transplant. In press 2015. doi: 10.1111/ajt.13624.
32. Loupy A, Hill GS, Suberbielle C, et al., Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA). Am J Transplant 2011; 11: 56-65.
33. Gaston RS, Cecka JM, Kasiske BL, et al., Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure. Transplantation 2010; 90: 68-74.
34. Kieran N, Wang X, Perkins J, et al., Combination of peritubular capillary C4d and transplant glomerulopathy predicts late renal allograft failure. J Am Soc Nephrol 2009; 20: 2260-2268.
35. Gupta A, O'Broin P, Bao Y, et al., Clinical and molecular significance of microvascular inflammation in transplant kidney biopsies. Kidney Int 2016; 89: 217-225.
36. Sellarés J, Reeve J, Loupy A, et al., Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am J Transplant 2013; 13: 971-983.
37. Salazar IDR, Lopez MM, Chang J, Halloran PF,. Reassessing the significance of intimal arteritis in kidney transplant biopsy specimens. J Am Soc Nephrol 2015; 26: 3190-3198.
38. Sis B, Bagnasco SM, Cornell LD, et al., Isolated endarteritis and kidney transplant survival: A multicenter collaborative study. J Am Soc Nephrol 2015; 26: 1216-1227.
39. Lesage J, Noel R, Lapointe I, et al., Donor-specific antibodies, C4d and their relationship with the prognosis of transplant glomerulopathy. Transplantation 2015; 99: 69-76.
40. Hidalgo LG, Sis B, Sellares J, et al., NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: Evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant 2010; 10: 1812-1822.
41. Loupy A, Lefaucheur C, Vernerey D, et al., Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med 2013; 369: 1215-1226.
42. Sicard A, Ducreux S, Rabeyrin M, et al., Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss. J Am Soc Nephrol 2015; 26: 457-467.
43. Lefaucheur C, Viglietti D, Bentlejewski C, et al., IgG donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury. J Am Soc Nephrol 2015; doi: 10.1681/ASN.2014111120.