Cost-Effectiveness of a national initiative to improve hand hygiene compliance using the outcome of healthcare associated staphylococcus aureus bacteraemia

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Graves, Nicholas ^a   Page, Katie ^a   Martin, Elizabeth ^a   Brain, David ^a   Hall, Lisa ^a   Campbell, Megan ^a   Fulop, Naomi ^b   Jimmeison, Nerina ^a   White, Katherine ^a   Paterson, David ^a   Barnett, Adrian G ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUSTRALIA; CONTROLLED STUDY; COST CONTROL; COST EFFECTIVENESS ANALYSIS; HAND WASHING; HEALTH CARE COST; HEALTH PROGRAM; HOSPITAL ADMISSION; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; OUTCOME ASSESSMENT; PROTOCOL COMPLIANCE; PUBLIC HEALTH SERVICE; SENSITIVITY ANALYSIS; STAPHYLOCOCCAL BACTEREMIA; BACTEREMIA; COST BENEFIT ANALYSIS; ECONOMICS; INFECTION CONTROL; PHYSIOLOGY; RISK; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

BACTEREMIA; COST-BENEFIT ANALYSIS; GUIDELINE ADHERENCE; HAND HYGIENE; HUMANS; INFECTION CONTROL; MODELS, STATISTICAL; OUTCOME ASSESSMENT (HEALTH CARE); RISK; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84959432775     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148190     Document Type: Article

References (59)

1. Kallen AJ, Mu Y, Bulens S, Reingold A, Petit S, Gershman K, et al. Health care-associated invasive MRSA infections, 2005-2008. JAMA. 2010; 304(6):641-8. Epub 2010/08/12. doi:10.1001/jama.2010.1115 PMID: 20699455.
2. Kohn LT CJ, Donaldson MS, . To Err Is Human: Building a Safer Health System. National Academy Press. Washington, DC.: Institute of Medicine of the National Academy of Sciences; 1999.
3. Allegranzi B, Gayet-Ageron A, Fau-Damani N, Damani N, Fau-Bengaly L, Bengaly L, Fau-McLaws M-L, McLaws Ml, Fau-Moro M-L, Moro Ml, Fau-Memish Z, et al. Global implementation of WHO's multimodal strategy for improvement of hand hygiene: A quasi-experimental study. (1474-4457 (Electronic)).
4. Reichardt C, Koniger D, Bunte-Schonberger K, van der Linden P, Monch N, Schwab F, et al. Three years of national hand hygiene campaign in Germany: what are the key conclusions for clinical practice? J Hosp Infect. 2013; 83 Suppl 1:S11-S6. Epub 2013/03/15. doi:10.1016/s0195-6701(13)60004-3 PMID: 23453170.
5. Stone SP, Fuller C, Fau-Savage J, Savage J, Fau-Cookson B, Cookson B, Fau-Hayward A, Hayward A Fau-Cooper B, Cooper B, Fau-Duckworth G, et al. Evaluation of the national Cleanyourhands campaign to reduce Staphylococcus aureus bacteraemia and Clostridium difficile infection in hospitals in England and Wales by improved hand hygiene: four year, prospective, ecological, interrupted time series study. (1756-1833 (Electronic)). D-NLM: PMC3343183 EDAT- 2012/05/05 06:00 MHDA- 2012/06/27 06:00 CRDT- 2012/05/05 06:00 PST-epublish.
6. Naikoba S, Hayward A. The effectiveness of interventions aimed at increasing handwashing in healthcare workers-a systematic review. 2001;(0195-6701 (Print)).
7. Gould DJ, Moralejo D, Drey N, Chudleigh JH. Interventions to improve hand hygiene compliance in patient care. Cochrane Database of Systematic Reviews 2010;Issue 9. Art. No.: CD005186. doi:10.1002/14651858.CD005186.pub3.
8. Huis A, van Achterberg T Fau-de Bruin M, de Bruin M Fau-Grol R, Grol R ,Fau-Schoonhoven L, Schoonhoven L, Fau-Hulscher M, Hulscher M. A systematic review of hand hygiene improvement strategies: A behavioural approach. (1748-5908 (Electronic)). D-NLM: PMC3517511 EDAT- 2012/09/18 06:00 MHDA- 2013/04/23 06:00 CRDT- 2012/09/18 06:00 PHST- 2012/01/11 [received] PHST- 2012/08/23 [accepted] PHST- 2012/09/14 [aheadofprint] AID-1748-5908-7-92 [pii] AID-10.1186/1748-5908-7-92 [doi] PST-epublish.
9. Schweizer ML, Reisinger Hs Fau-Ohl M, Ohl M., Fau-Formanek MB, Formanek Mb Fau-Blevins A, Blevins A Fau-Ward MA, Ward Ma Fau-Perencevich EN, et al. Searching for an optimal hand hygiene bundle: A meta-analysis. (1537-6591 (Electronic)).
10. Luangasanatip N, Hongsuwan M, Limmathurotsakul D, Lubell Y, Lee AS, Harbarth S, et al. Comparative efficacy of interventions to promote hand hygiene in hospital: systematic review and network metaanalysis. BMJ. 2015; 351:h3728. Epub 2015/07/30. doi:10.1136/bmj.h3728 PMID: 26220070; PubMed Central PMCID: PMCPMC4517539.
11. Perencevich EN, Stone PW, Wright SB, Carmeli Y, Fisman DN, Cosgrove SE. Raising standards while watching the bottom line: making a business case for infection control. Infect Control Hosp Epidemiol. 2007; 28(10):1121-33. Epub 2007/10/16. doi:10.1086/521852 PMID: 17933084.
12. McLaws ML, Pantle AC, Fitzpatrick KR, Hughes CF. More than hand hygiene is needed to affect methicillin- resistant Staphylococcus aureus clinical indicator rates: clean hands save lives, part IV. Med J Aust. 2009; 191(8 Suppl):S26-S31. Epub 2009/10/20. PMID: 19835528.
13. Graves N. Economics and preventing hospital-acquired infection. Emerg Infect Dis. 2004; 10(4):561-6. PMID: ISI:000220578600001.
14. Graves N, Halton K, Lairson D. Economics and preventing hospital-acquired infection: broadening the perspective. Infect Control Hosp Epidemiol. 2007; 28(2):178-84. Epub 2007/02/01. ICHE2005206 [pii] doi:10.1086/510787 PMID: 17265399.
15. Grayson ML, Russo PL. The national hand hygiene initiative. Med J Aust. 2009; 191(8):420-1. Epub 2009/10/20. PMID: 19835531.
16. Sax H, Allegranzi B, Uckay I, Larson E, Boyce J, Pittet D. 'My five moments for hand hygiene': A usercentred design approach to understand, train, monitor and report hand hygiene. J Hosp Infect. 2007; 67 (1):9-21. Epub 2007/08/28. doi:10.1016/j.jhin.2007.06.004 PMID: 17719685.
17. Collignon PJ, Wilkinson IJ, Gilbert GL, Grayson ML, Whitby RM. Health care-associated Staphylococcus aureus bloodstream infections: A clinical quality indicator for all hospitals. Med J Aust. 2006; 184 (8):404-6. Epub 2006/04/19. PMID: 16618240.
18. Collignon Pj, Fau-Cruickshank M, Cruickshank M. Staphylococcus aureus bacteraemias: Time to act. (0025-729X (Print)). Centre for Healthcare Related Infection Surveillance and Prevention. http://www.health.qld.gov.au/qhpolicy/docs/gdl/qh-gdl-321-1-1.pdf. 2013.
19. Centre for Healthcare Related Infection Surveillance and Prevention. http://www.health.qld.gov.au/qhpolicy/docs/gdl/qh-gdl-321-1-1.pdf. 2013.
20. Pantle AC, Fitzpatrick KR, McLaws ML, Hughes CF. A statewide approach to systematising hand hygiene behaviour in hospitals: clean hands save lives, part I. Med J Aust. 2009; 191(8 Suppl):S8-S12. Epub 2009/10/20. PMID: 19835530.
21. Johnson PD, Martin R, Burrell LJ, Grabsch EA, Kirsa SW, O'Keeffe J, et al. Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. Med J Aust 2005; 183(10):509-14. PMID: 16296963.
22. Grayson ML, Jarvie LJ, Martin R, Johnson PD, Jodoin ME, McMullan C, et al. Significant reductions in methicillin-resistant Staphylococcus aureus bacteraemia and clinical isolates associated with a multisite, hand hygiene culture-change program and subsequent successful statewide roll-out. Med J Aust. 2008; 188(11):633-40. PMID: 18513171.
23. Barnett A, Page K, Campbell M, Brain D, Martin E, Winters S, et al. Changes in healthcare associated infections after the introduction of the National Hand Hygiene Initiative. Healthcare Infection. 2014; 19:128-34.
24. Playford EG, McDougall D, McLaws ML. Problematic linkage of publicly disclosed hand hygiene compliance and health care-associated Staphylococcus aureus bacteraemia rates. Med J Aust. 2012; 197 (1):29-30. Epub 2012/07/06. PMID: 22762227.
25. Hand Hygiene Australia. National Data, available at http://www.hha.org.au/LatestNationalData.aspx. 2014.
26. Srigley JA, Furness CD, Baker GR, Gardam M. Quantification of the Hawthorne effect in hand hygiene compliance monitoring using an electronic monitoring system: A retrospective cohort study. BMJ Qual Saf 2014; 23(12):974-80. D-NLM: PMC4251174 OTO-NOTNLM. doi:10.1136/bmjqs-2014-003080PMID: 25002555.
27. Azim S, McLaws ML. Doctor, do you have a moment? National Hand Hygiene Initiative compliance in Australian hospitals. Med J Aust. 2014; 200(9):534-7. Epub 2014/05/20. PMID: 24835717.
28. ACSQHC. Surveillance of Healthcare Associated Infections: Staphylococcus aureus bacteraemia & Clostridium difficile infection. Version 4.0. Available here: http://www.safetyandquality.gov.au/wpcontent/uploads/2012/03/Data-Set-Specification-Surveillance-of-Healthcare-Associated-Infections-SAB-and-CDI-V-4.pdf. 2012.
29. Australian Comission on Safety and Quality in Health Care. Implementation Guide for Surveillance of Staphylococcus aureus Bacteraemia. Availabale here http://www.safetyandquality.gov.au/wp-content/uploads/2012/02/SAQ019-Implementation-guide-SAB-v10.pdf. Sydney, Australia2013.
30. Pittet D, Tarara D, Wenzel RP. Nosocomial Bloodstream Infection in critically Ill Patients. Excess length of stay, extra costs and attributable mortality. J Am Med Assoc. 1994; 271:1598-601.
31. van Hal SJ, Jensen SO, Vaska VL, Espedido BA, Paterson DL, Gosbell IB. Predictors of mortality in Staphylococcus aureus Bacteremia. Clin Microbiol Rev. 2012; 25(2):362-86. Epub 2012/04/12. doi:10.1128/cmr.05022-11 PMID: 22491776; PubMed Central PMCID: PMCPmc3346297.
32. Weinstein MC. Foundation of cost-effectiveness analysis for health and medical practices. New Engl J Med. 1981; 296(31):716-21.
33. Russo PL, Cheng AC, Richards M, Graves N, Hall L. Variation in health care-associated infection surveillance practices in Australia. American Journal of Infection Control. doi:10.1016/j.ajic.2015.02.029.
34. National Institute for Health and Clinical Excellence. Guide to the methods of technology appraisal 2013 available at, http://www.nice.org.uk/article/pmg9/chapter/the-reference-case#/discounting2013.
35. Barnett AG, Page K, Campbell M, Brain D, Martin E, Rashleigh-Rolls R, et al. Changes in healthcareassociated Staphylococcus aureus bloodstream infections after the introduction of a national hand hygiene initiative. Infect Control Hosp Epidemiol. 2014; 35(8):1029-36. Epub 2014/07/16. doi:10.1086/677160 PMID: 25026620.
36. Harris AD, Bradham DD, Baumgarten M, Zuckerman IH, Fink JC, Perencevich EN. The use and interpretation of quasi-experimental studies in infectious diseases. Clin Infect Dis. 2004; 38(11).
37. Page K, Graves N, Halton K, Barnett AG. Humans, 'things' and space: costing hospital infection control interventions. J Hosp Infect. 2013; 84(3):200-5. Epub 2013/05/22. doi:10.1016/j.jhin.2013.03.006 PMID: 23688708.
38. Page K, Barnett AG, Campbell M, Brain D, Martin E, Fulop N, et al. Costing the Australian National Hand Hygiene Initiative. J Hosp Infect. 2014; 88(3):141-8. Epub 2014/08/06. doi:10.1016/j.jhin.2014.06.005PMID: 25092619.
39. Beyersmann J, Gastmeier P, Grundmann H, Barwolff S, Geffers C, Behnke M, et al. Use of multistate models to assess prolongation of intensive care unit stay due to nosocomial infection. Infect Control Hosp Epidemiol. 2006; 27(5):493-9. PMID: 16671031.
40. Barnett AG, Beyersmann J, Allignol A, Rosenthal VD, Graves N, Wolkewitz M. The time-dependent bias and its effect on extra length of stay due to nosocomial infection. Value Health. 2011; 14(2):381-6. Epub 2011/03/16. doi:10.1016/j.jval.2010.09.008 PMID: 21402305.
41. Barnett AG, Page K, Campbell M, Martin E, Rashleigh-Rolls R, Halton K, et al. The increased risks of death and extra lengths of hospital and ICU stay from hospital-acquired bloodstream infections: A casecontrol study. BMJ Open. 2013; 3(10):e003587. Epub 2013/11/02. doi:10.1136/bmjopen-2013-003587 PMID: 24176795; PubMed Central PMCID: PMCPMC3816236.
42. Australian Institute of Health and Welfare accessed 1st March 2014. Australian hospital statistics 2011-12. Health services series no. 50. Cat. no. HSE 134 (Table B.S11), available here (http://www.aihw.gov.au/publication-detail/?id=60129543133). Canberra: AIHW; 2013.
43. Rechner IJ, Lipman J. The costs of caring for patients in a tertiary referral Australian Intensive Care Unit. Anaesth Intensive Care 2005; 33(4):477-82. PMID: 16119489.
44. Australian Institute of Health & Welfare. Australia's health 2010. Australia's health series no. 12. Cat. no. AUS 122, available here https://www.aihw.gov.au/WorkArea/DownloadAsset.aspx?id=6442452958. 2010. Canberra: AIHW.
45. Australian Institute of Health and Welfare (AIHW) accessed 1st March 2014. Life Expectancy, available at http://www.aihw.gov.au/deaths/life-expectancy/, 2012.
46. George B HA, Mitchell A, . Cost-effectiveness analysis and the consistency of decision making: evidence from pharmaceutical reimbursement in Australia (1991 to 1996). Pharmacoeconomics. 2001; 19:1103-9. PMID: 11735677.
47. Claxton K. The irrelevance of inference: A decision-making approach to the stochastic evaluation of health care technologies. Journal of Health Economics. 1999; 18:341-64. PMID: 10537899.
48. Claxton K, Sculpher M, McCabe C, Briggs A, Akehurst R, Buxton M, et al. Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra. Health Econ. 2005; 14:339-47. PMID: 15736142.
49. Fenwick E, Claxton K, Sculpher M. Representing uncertainty: The role of cost-effectiveness acceptability curves. Health Economics. 2001; 10(8):779-87. PMID: 11747057.
50. Graves N, Halton K, Page K, Barnett A. Linking scientific evidence and decision making: A case study of hand hygiene interventions. Infect Control Hosp Epidemiol. 2013; 34(4):424-9. Epub 2013/03/08. doi:10.1086/669862 PMID: 23466917.
51. Australian Institute of Health and Welfare. Australian hospital statistics 2012-13: Staphylococcus aureus bacteraemia in Australian public hospitals. Health services series no 53 Cat no HSE 144 [Internet]. 2013.
52. Page K, Barnett AG, Campbell M, Brain D, Martin E, Fulop N, et al. Costing the Australian National Hand Hygeine Initiative. Available here http://www.cre-rhai.org.au/manuscripts-in-press Journal of Hospital Infection. In Press.
53. Dick AW, Perencevich EN, Pogorzelska-Maziarz M, Zwanziger J, Larson EL, Stone PW. A decade of investment in infection prevention: A cost-effectiveness analysis. (1527-3296 (Electronic)).
54. Lawes T, Lopez-Lozano JM, Nebot CA, Macartney G, Subbarao-Sharma R, Dare CR, et al. Effects of national antibiotic stewardship and infection control strategies on hospital-associated and communityassociated meticillin-resistant Staphylococcus aureus infections across a region of Scotland: A non-linear time-series study. Lancet Infect Dis. 2015; 15(12):1438-49. Epub 2015/09/29. doi:10.1016/s1473-3099(15)00315-1PMID: 26411518.
55. Lawes T, Lopez-Lozano JM, Nebot C, Macartney G, Subbarao-Sharma R, Dare CR, et al. Turning the tide or riding the waves? Impacts of antibiotic stewardship and infection control on MRSA strain dynamics in a Scottish region over 16 years: non-linear time series analysis. BMJ Open. 2015; 5(3):e006596. Epub 2015/03/31. doi:10.1136/bmjopen-2014-006596 PMID: 25814495; PubMed Central PMCID: PMCPMC4386222.
56. Brown CA, Lilford RJ. The stepped wedge trial design: A systematic review. BMC Med Res Methodol. 2006; 6:54. Epub 2006/11/10. doi:10.1186/1471-2288-6-54 PMID: 17092344; PubMed Central PMCID: PMC1636652.
57. Lawes TG, Gould IM. Dissecting a multi-intervention methicillin-resistant Staphylococcus aureus prevention bundle may miss emergent properties. Clin Infect Dis. 2012; 55(7):1027-8; author reply 8-9. Epub 2012/07/05. doi:10.1093/cid/cis602 PMID: 22761407.
58. Stewardson AJ, Harbarth S, Graves N. Valuation of hospital bed-days released by infection control programs: A comparison of methods. Infect Control Hosp Epidemiol. 2014; 35(10):1294-7. Epub 2014/09/10. doi:10.1086/678063 PMID: 25203185.
59. Graves N, Harbarth S, Beyersmann J, Barnett A, Halton K, Cooper B. Estimating the cost of health care-associated infections: mind your p's and q's. Clin Infect Dis. 2010; 50(7):1017-21. Epub 2010/02/25. doi:10.1086/651110PMID:20178419.