Prolonged PR interval, first-degree heart block and adverse cardiovascular outcomes: A systematic review and meta-analysis

Heart

Volumn 102, Issue 9, 2016, Pages 672-680

  Kwok, Chun Shing ^a,b   Rashid, Muhammad ^a,c   Beynon, Rhys ^b   Barker, Diane ^b   Patwala, Ashish ^b   Morley Davies, Adrian ^b   Satchithananda, Duwarakan ^b   Nolan, James ^a,b   Myint, Phyo K ^d   Buchan, Iain ^e   Loke, Yoon K ^f   Mamas, Mamas A ^a,b,e  

^a Primary Care and Health Sciences   (United Kingdom)

^b UNIVERSITY HOSPITAL OF NORTH STAFFORDSHIRE   (United Kingdom)

^c WHISTON HOSPITAL   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE OUTCOME; ARTICLE; ATRIAL FIBRILLATION; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; FIRST DEGREE ATRIOVENTRICULAR BLOCK; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CONDUCTION DISTURBANCE; HUMAN; ISCHEMIC HEART DISEASE; MORTALITY; PRIORITY JOURNAL; PROLONGED PR INTERVAL; SYSTEMATIC REVIEW; TRANSIENT ISCHEMIC ATTACK; ADULT; AGED; ATRIOVENTRICULAR BLOCK; BRUGADA SYNDROME; COMPLICATION; FEMALE; MALE; META ANALYSIS; MIDDLE AGED; OBSERVATIONAL STUDY; PROGNOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ATRIOVENTRICULAR BLOCK; BRUGADA SYNDROME; FEMALE; HUMANS; MALE; MIDDLE AGED; OBSERVATIONAL STUDIES AS TOPIC; PROGNOSIS;

EID: 84959378378     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2015-308956     Document Type: Article

References (32)

1. Bexton RS, Camm AJ. First degree atrioventricular block. Eur Heart J 1984;5(Suppl A):107-9.
2. Mymin D, Mathewson FA, Tate RB, et al. The natural history of primary first-degree atrioventricular heart block. N Engl J Med 1986;315:1183-7.
3. Perlman LV, Ostrander LD, Keller JB, et al. An epidemiologic study of first degree atrioventricular block in Tecumseh, Michigan. Chest 1971;59:40-6.
4. Aro AL, Anttonen O, Kerola T, et al. Prognostic significance of prolonged PR interval in the general population. Eur Heart J 2014;35:123-9.
5. Heart Block. http://www.nhs.uk/Conditions/Heart-block/Pages/Introduction.aspx (accessed 31 Oct 2015).
6. Heart Block. http://my.clevelandclinic.org/services/heart/disorders/arrhythmia/heart-block (accessed 31 Oct 2015).
7. Atrioventricular block. http://www.merckmanuals.com/professional/cardiovasculardisorders/arrhythmias-and-conduction-disorders/atrioventricular-block (accessed 31 Oct 2015).
8. Epstein AE, DiMarco JP, Ellebogen KA, et al. ACC/AHA/HRS 2008 guidelines for device-based therapy for cardiac rhythm abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 2008;117:e350-408.
9. Brignole M, Auricchio A, Baron-Esquivias G, et al. 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J 2013;34:2281-329.
10. Erikssen J, Otterstad JE. Natural course of a prolonged PR interval and the relation between PR and incidence of coronary heart disease. A 7-year follow-up study of 1832 apparently health men age 40-59 years. Clin Cardiol 1984;7:6-13.
11. Rajala S, Haavisto M, Kaltiala K, et al. ECG findings and survival in very old people. Eur Heart J 1985;6:247-52.
12. Cheng S, Keyes MJ, Larson MG, et al. Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA 2009;301:2571-7.
13. Nielsen JB, Pietersen A, Graff C, et al. Risk of atrial fibrillation as a function of electrocardiographic PR interval: results from the Copenhagen ECG study. Heart Rhythm 2013;10:1249-56.
14. Perez MV, Dewey FE, Marcus R, et al. Electrocardiographic predictors of atrial fibrillation. Am Heart J 2009;158:622-8.
15. Soliman EZ, Prineas RJ, Case LD, et al. Ethnic distribution of ECG predictors of atrial fibrillation and its impact of understanding the ethnic distribution of ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) Study. Stroke 2009;40:1204-11.
16. Uhm JS, Shim J, Wi J, et al. First-degree atrioventricular block is associated with advanced atrioventricular block, atrial fibrillation and left ventricular dysfunction in patients with hypertension. J Hypertension 2014;32:1115-20.
17. Hisamatsu T, Miura K, Fujiyoshi A, et al. Long-term outcomes associated with prolonged PR interval in the general Japanese population. Int J Cardiol 2015;184:291-3.
18. Cheng M, Lu X, Huang J, et al. Electrocardiographic PR prolongation and atrial fibrillation risk: a meta-analysis of prospective cohort studies. J Cardiovasc Electrophysiol 2015;26:36-41.
19. Crisel RK, Farzaneh-Far R, Na B, et al. First-degree atrioventricular block is associated with heart failure and death in persons with stables coronary artery disease: data from the Heart and Soul Study. Eur Heart J 2011;32:1875-80.
20. Knuiman M, Briffa T, Divitini M, et al. A cohort study examination of established and emerging risk factors for atrial fibrillation: the Busselton Health Study. Eur J Epidemiol 2014;29:181-90.
21. Kobayashi T, Watanabe M, Kokubo Y, et al. Prolonged PR interval is significantly associated with increased risk of cardiovascular diseases and stroke in a population-based cohort study. Circulation 2014;130:A13451.
22. Magnani JW, Wang N, Nelson KP, et al. Electrographic PR interval and adverse outcomes in older adults: the Health, Aging, and Body Composition study. Circ Arrhythm Electrophysiol 2013;6:84-90.
23. Soliman EZ, Cammarata M, Li Y. Explaining the inconsistent associations of PR interval with mortality: the role of P-duration contribution to the length of PR interval. Heart Rhythm 2014;11:93-8.
24. Brown RW, Hunt D, Sloman JG. The natural history of atrioventricular conduction defects in acute myocardial infarction. Am Heart J 1969;78:460-6.
25. Waller BF, Gering LE, Branyas NA, et al. Anatomy, histology and pathology of the cardiac conduction system-Part V. Clin Cardiol 1993;16:565-9.
26. de Jong S, van Veen TAB, van Rijen HVM, et al. Fibrosis and cardiac arrhythmias. J Cardiovasc Pharmacol 2011;57:630-8.
27. Kistler PM, Sanders P, Fynn SP, et al. Electrophysiologic and electroanatomic changes in the human atrium associated with age. J Am Coll Cardiol 2004;44:109-16.
28. Kojodjojo P, Kanagaratnam P, Markides V, et al. Age-related changes in human left and right atrial conduction. J Cardiovasc Electrophyiol 2006;17:120-7.
29. Kitchin AH, Milne JS. Longitudinal survey of ischaemic heart disease in randomly selected sample of older population. Br Heart J 1997;39:889-93.
30. Rose G, Baxter PJ, Reid DD, et al. Prevalence and prognosis of electrocardiographic findings in middle-aged men. Br Heart J 1978;40:636-43.
31. Ostor E, Schnohr P, Jensen G, et al. Electrocardiographic findings and their association with mortality in the Copenhagen City Heart Study. Eur Heart J. 1981;2:317-28.
32. Perk J, De Backer G, Gohlke H, et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012;33:1635-701.