mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue

EMBO Molecular Medicine

Volumn 8, Issue 3, 2016, Pages 232-246

  Albert, Verena ^a   Svensson, Kristoffer ^a   Shimobayashi, Mitsugu ^a   Colombi, Marco ^a   Muñoz, Sergio ^b,c   Jimenez, Veronica ^b,c   Handschin, Christoph ^a   Bosch, Fatima ^b,c   Hall, Michael N ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Brown adipose tissue; Glucose uptake; mTORC2; Thermogenesis

Indexed keywords

CYCLIC AMP; HEXOKINASE; HEXOKINASE II; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN EPAC1; PROTEIN KINASE B BETA; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GLUCOSE; MULTIPROTEIN COMPLEX; ONCOPROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; COLD SENSITIVITY; COLD TOLERANCE; CONTROLLED STUDY; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; THERMOGENESIS; THERMOREGULATION; ANIMAL; METABOLISM;

ADIPOSE TISSUE, BROWN; ANIMALS; GLUCOSE; GLYCOLYSIS; MICE; MULTIPROTEIN COMPLEXES; ONCOGENE PROTEIN V-AKT; THERMOGENESIS; TOR SERINE-THREONINE KINASES;

EID: 84959327330     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505610     Document Type: Article

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