Thrombelastography detects dabigatran at therapeutic concentrations in vitro to the same extent as gold-standard tests

International Journal of Cardiology

Volumn 208, Issue , 2016, Pages 14-18

  Solbeck, Sacha ^a   Ostrowski, Sisse R ^a   Stensballe, Jakob ^a   Johansson, Pär I ^a,b  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Anticoagulation; Dabigatran; Ecarin clotting time; Thrombelastography; Thrombin time

Indexed keywords

DABIGATRAN; ECARIN; ANTITHROMBIN;

ADULT; ARTICLE; BLOOD CLOTTING TIME; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE KIDNEY FUNCTION RELATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; FEMALE; GOLD STANDARD; HUMAN; IN VITRO STUDY; MALE; PRIORITY JOURNAL; REACTION TIME; THROMBIN TIME; THROMBOELASTOGRAPHY; VISCOELASTICITY; BLOOD; BLOOD CLOTTING; CARDIOVASCULAR DISEASES; DRUG EFFECTS; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; STANDARD; STANDARDS;

ADULT; ANTITHROMBINS; BLOOD COAGULATION; CARDIOVASCULAR DISEASES; DABIGATRAN; DRUG MONITORING; FEMALE; HUMANS; MALE; MIDDLE AGED; REFERENCE STANDARDS; THROMBELASTOGRAPHY;

EID: 84959273601     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.01.148     Document Type: Article

References (20)

1. L. Wallentin, S. Yusuf, M.D. Ezekowitz, M. Alings, M. Flather, M.G. Franzosi, and et al. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial Lancet 376 9745 Sep. 18 2010 975 983
2. T.L. Lindahl, F. Baghaei, I.F. Blixter, K.M. Gustafsson, L. Stigendal, M. Sten-Linder, and et al. Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays Thromb. Haemost. 105 2 Feb. 2011 371 378
3. R.J. Van, J. Stangier, S. Haertter, K.H. Liesenfeld, W. Wienen, M. Feuring, and et al. Dabigatran etexilate - a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity Thromb. Haemost. 103 6 Jun. 2010 1116 1127
4. J. Stangier, K. Rathgen, H. Stahle, D. Gansser, and W. Roth The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects Br. J. Clin. Pharmacol. 64 3 Sep. 2007 292 303
5. J. Stangier, and M. Feuring Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran Blood Coagul. Fibrinolysis 23 2 Mar. 2012 138 143
6. P.I. Johansson Goal-directed hemostatic resuscitation for massively bleeding patients: the Copenhagen concept Transfus. Apher. Sci. 43 3 Dec. 2010 401 405
7. J. Stensballe, S.R. Ostrowski, and P.I. Johansson Viscoelastic guidance of resuscitation Curr. Opin. Anaesthesiol. 27 2 Apr. 2014 212 218
8. P.I. Johansson, J. Stensballe, R. Oliveri, C.E. Wade, S.R. Ostrowski, and J.B. Holcomb How I treat patients with massive hemorrhage Blood 124 20 Nov. 13 2014 3052 3058
9. S. Solbeck, M.A. Meyer, P.I. Johansson, A.S. Meyer, B.A. Cotton, J. Stensballe, and et al. Monitoring of dabigatran anticoagulation and its reversal in vitro by thrombelastography Int. J. Cardiol. Aug. 4 2014
10. P.K. Davis, H. Musunuru, M. Walsh, R. Mitra, V. Ploplis, and F.J. Castellino The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine Thromb. Haemost. 108 3 Sep. 2012 586 588
11. Y. Xu, W. Wu, L. Wang, M. Chintala, A.S. Plump, M.L. Ogletree, and et al. Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro Blood Coagul. Fibrinolysis 24 3 Apr. 2013 332 338
12. R. Artang, J.D. Nielsen, and G. Gregg Monitoring novel anticoagulants dabigatran, rivaroxaban and apixaban by thrombelastography. Proof of concept Blood 122 21 2013 4813
13. Boehringer Ingelheim Prescribing information for PRADAXA (dabigatran exexilate mesylate) capsules for oral use [package insert] Squibb 2014 (Ref Type: Pamphlet)
14. J. Stangier, H. Stahle, K. Rathgen, and R. Fuhr Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects Clin. Pharmacokinet. 47 1 2008 47 59
15. Insert Kit HYPHEN BioMed. 2014 (Ref Type: Pamphlet)
16. G. Nowak The ecarin clotting time, a universal method to quantify direct thrombin inhibitors Pathophysiol. Haemost. Thromb. 33 4 Jul. 20 2003 173 183
17. J.H. Levy, D. Faraoni, J.L. Spring, J.D. Douketis, and C.M. Samama Managing new oral anticoagulants in the perioperative and intensive care unit setting Anesthesiology 118 6 Jun. 2013 1466 1474
18. P.I. Johansson, M.S. Svendsen, J. Salado, L. Bochsen, and A.T. Kristensen Investigation of the thrombin-generating capacity, evaluated by thrombogram, and clot formation evaluated by thrombelastography of platelets stored in the blood bank for up to 7 days Vox Sang. 94 2 Feb. 2008 113 118
19. J.D. Dias, K. Norem, D.D. Doorneweerd, R.L. Thurer, M.A. Popovsky, and L.A. Omert Use of thromboelastography (TEG) for detection of new oral anticoagulants Arch. Pathol. Lab. Med. 139 5 May 2015 665 673
20. P.I. Johansson Coagulation monitoring of the bleeding traumatized patient Curr. Opin. Anaesthesiol. 25 2 Apr. 2012 235 241