Randomized, double-blind, placebocontrolled study on decolonization procedures for methicillin-resistant Staphylococcus aureus (MRSA) among HIV-infected adults

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Weintrob, Amy ^a,b   Bebu, Ionut ^a   Agan, Brian ^a   Diem, Alona ^a,c   Johnson, Erica ^a,d   Lalani, Tahaniyat ^a,e   Wang, Xun ^a   Bavaro, Mary ^a,c   Ellis, Michael ^f   Mende, Katrin ^a,d   Crum Cianflone, Nancy ^a,c  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^d SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

^e NAVAL MEDICAL CENTER PORTSMOUTH   (United States)

^f Uniformed Services University of the Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; HEXACHLOROPHENE; PLACEBO; PSEUDOMONIC ACID;

ADULT; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MULTICENTER STUDY; NONHUMAN; PRACTICE GUIDELINE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SKIN AND SOFT TISSUE INFECTION; SKIN INFECTION; SOFT TISSUE INFECTION; DRUG EFFECTS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGY; MIDDLE AGED; STAPHYLOCOCCAL INFECTIONS; VIROLOGY;

ADULT; ANTI-BACTERIAL AGENTS; DOUBLE-BLIND METHOD; FEMALE; HEXACHLOROPHENE; HIV INFECTIONS; HUMANS; MALE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MIDDLE AGED; MUPIROCIN; PROSPECTIVE STUDIES; STAPHYLOCOCCAL INFECTIONS;

EID: 84959266801     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128071     Document Type: Article

References (43)

1. Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, Carey RB. Methicillin-resistantS. aureus infections among patients in the emergency department. N Engl J Med. 2006 Aug. 17; 355(7):666-74. PMID: 16914702
2. King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of communityacquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med. 2006;144:309-17. PMID: 16520471
3. Hidron AI, Kourbatova EV, Halvosa JS, Terrell BJ, McDougal LK, Tenover FC, et al. Riskfactors for colonization with methicillin-resistant Staphylococcus aureus (MRSA) in patients admitted to an urban hospital: emergence of community-associated MRSA nasal carriage. Clin Infect Dis. 2005;41:159-166. PMID: 15983910
4. Popovich KJ, Hota B, Aroutcheva A, Kurien L, Patel J, Lyles-Banks R. Community-associated methicillin-resistant Staphylococcus aureus colonization burden in HIV-infected patients. Clin Infect Dis. 2013 Apr; 56(8):1067-74. doi: 10.1093/cid/cit010 PMID: 23325428
5. Seybold U, Supthut-Schroder B, Draenert R, Hogardt M, Bogner JR. Prevalence and riskfactors of nasal colonization with Staphylococcus aureus-association with HIV infection in older patients. Scand J Infect Dis. 2009;41(1):63-6. doi: 10.1080/00365540802460000 PMID: 18855226
6. Shet A, Mathema B, Mediavilla JR, Kishii K, Mehandru S, Jeane-Pierre P. Colonization and subsequent skin and soft tissue infection due to methicillin-resistant Staphylococcus aureus in a cohort of otherwise healthy adults infected with HIV type 1. J Infect Dis. 2009 Jul. 1; 200(1):88-93. doi: 10.1086/599315 PMID: 19463064
7. Miller M, Cespedes C, Bhat M, Vavagiakis P, Klein RS, Lowy FD. Incidence and persistence of Staphylococcus aureus nasal colonization in a community sample of HIV-infected and-uninfected drug users. Clin Infect Dis. 2007 Aug. 1; 45(3):343-6. PMID: 17599312
8. Crum-Cianflone NF, Burgi A, Hale BR. Increasing rates of community-acquired MRSA infections among HIV-infected persons. Int J STDAIDS. 2007;18:521-6. PMID: 17686212
9. Mathews WC, Caperna JC, Barber RE, Torriani FJ, Miller LG, May S, et al. Incidence of and riskfactors for clinically significant methicillin-resistant Staphylococcus aureus infection in a cohort of HIV-infected adults. J Acquir Immune Defic Syndr. 2005;40:155-160. PMID: 16186732
10. Ramsetty SK, Stuart LL, Blake RT, Parsons CH, Salgado CD. Risks for methicillin-resistant Staphylococcus aureus colonization or infection among patients with HIV infection. HIV Med. 2010 Jul. 1; 11(6):389-94. doi: 10.1111/j.1468-1293.2009.00802.x PMID: 20059572
11. Diep BA, Chambers HF, Graber CJ, Szumowski JD, Miller LG, Han LL. Emergence of multidrug-resistant, community-associated, methicillin-resistant Staphylococcus aureus clone USA300 in men who have sex with men. Ann Intern Med. 2008 Feb. 19; 148(4):249-57. PMID: 18283202
12. Lee NE, Taylor MM, Bancroft E, Ruane PJ, Morgan M, McCoy L, et al. Risk factors for community-associated methicillin-resistant Staphylococcus aureus skin infections among HIV-positive men who have sex with men. Clin Infect Dis. 2005;40:1529-1534. PMID: 15844078
13. Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers Clin Infect Dis. 2004;39:971-979. PMID: 15472848
14. Peters PJ, Brooks JT, McAllister SK, Limbago B, Lowery HK, Fosheim G. Methicillin-resistant Staphylococcus aureus colonization of the groin and risk for clinical infection among HIV-infected adults. Emerg Infect Dis. 2013 Apr; 19(4):623-9. doi: 10.3201/eid1904.121353 PMID: 23631854
15. Szumowski JD, Wener KM, Gold HS, Wong M, Venkataraman L, Runde CA. Methicillin-resistant Staphylococcus aureus colonization, behavioral riskfactors, and skin and soft-tissue infection at an ambulatory clinic serving a large population of HIV-infected men who have sex with men. Clin Infect Dis. 2009 Jul. 1; 49(1):118-21. doi: 10.1086/599608 PMID: 19480576
16. Kluytmans J, Van Belkum A, Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 1997 Jul; 10(3):505-20. PMID: 9227864
17. Wertheim HF, Melles DC, Vos MC, Van Leeuwen W, Van Belkum A, Verbrugh HA, et al. The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis. 2005 Dec; 5(12):751-62. PMID: 16310147
18. Perl TM, Cullen JJ, Wenzel RP, Zimmerman MB, Pfaller MA, Sheppard D, et al. Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections. N Engl J Med 2002;346:1871-7. PMID: 12063371
19. Sandri AM, Dalarosa MG, Ruschel De Alcantara L, Da Silva Elias L, Zavascki AP. Reduction in incidence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in an intensive care unit: role of treatment with mupirocin ointment and chlorhexidine baths for nasal carriers of MRSA. Infect Control Hosp Epidemiol 2006;27:185-7. PMID: 16465636
20. Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Avery TR. Targeted versus universal decolonization to prevent ICU infection. N Engl J Med. 2013 Jun. 13; 368(24):2255-65. doi: 10.1056/NEJMoa1207290 PMID: 23718152
21. Lobbedez T, Gardam M, Dedier H, Burdzy D, Chu M, Izatt S, et al. Routine use of mupirocin at the peritoneal catheter exit site and mupirocin resistance: still low after 7 years. Nephrol Dial Transplant 2004;19:3140-3. PMID: 15466881
22. Mody L, Kauffman CA, McNeil SA, Galecki A, Bradley SF. Mupirocin-based decolonization of Staphylococcus aureus carriers in residents of 2 long-term care facilities: a randomized, double-blind, placebocontrolled trial. Clin Infect Dis 2003;37:1467-74. PMID: 14614669
23. Mupirocin Study Group. Nasal mupirocin prevents Staphylococcus aureus exit-site infection during peritoneal dialysis. J Am Soc Nephrol. 1996 Nov; 7(11):2403-8. PMID: 8959632
24. Van Rijen MM, Bonten M, Wenzel RP, Kluytmans JA. Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic review. J Antimicrob Chemother. 2008 Feb; 61(2):254-61. doi: 10.1093/jac/dkm480 PMID: 18174201
25. Gordon RJ, Chez N, Jia H, Zeller B, Sobieszczyk M, Brennan C, et al. The NOSE study (nasal ointment for Staphylococcus aureus eradication): a randomized controlled trial of monthly mupirocin in HIV-infected individuals. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):466-72. doi: 10.1097/QAI. 0b013e3181ec2a68 PMID: 20686410
26. Ammerlaan HS, Kluytmans JA, Wertheim HF, Nouwen JL, Bonten MJ. Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review. Clin Infect Dis. 2009 Apr. 1; 48(7):922-30. doi: 10.1086/597291 PMID: 19231978
27. Martin JN, Perdreau-Remington F, Kartalija M, Pasi OG, Webb M, Gerberding JL, et al. A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease. J Infect Dis. 1999 Sep; 180(3):896-9. PMID: 10438389
28. Yang ES, Tan J, Eells S, Rieg G, Tagudar G, Miller LG. Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infections. Clin Microbiol Infect. 2010 May; 16(5):425-31. doi: 10.1111/j.1469-0691.2009.02836.x PMID: 19689469
29. Wertheim HF, Verveer J, Boelens HA, Van Belkum A, Verbrugh HA, Vos MC. Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults. Antimicrob Agents Chemother. 2005 Apr; 49(4):1465-7. PMID: 15793127
30. Brown DF, Edwards DI, Hawkey PM, Morrison D, Ridgway GL, Towner KJ, et al. Guidelines for the laboratory diagnosis and susceptibility testing of methicillin-resistant Staphylococcus aureus (MRSA). J Antimicrob Chemother. 2005 Dec; 56(6):1000-18. PMID: 16293678
31. McDonald LC, Lauderdale TL, Lo HJ, Tsai JJ, Hung CC. Colonization of HIV-infected outpatients in Taiwan with methicillin-resistant and methicillin-sensitive Staphylococcus aureus. In J STD AIDS 2003;14:473-7. PMID: 12869228
32. Villacian JS, Barkham T, Earnest A, Paton NI. Prevalence of and risk factors for nasal colonization with Staphylococcus aureus among human immunodeficiency virus-positive outpatients in Singapore. Infect Control Hosp Epidemiol 2004;25:438-40. PMID: 15188853
33. Pegues DA. Editorial commentary: search, destroy, and confirm: how to maximize the benefit and reduce the unintended consequences of contact precautions for control of methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2013 Jul; 57(2):185-7. doi: 10.1093/cid/cit214 PMID: 23572485
34. Robicsek A, Beaumont JL, Peterson LR. Duration of colonization with methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2009 Apr. 1; 48(7):910-3. doi: 10.1086/597296 PMID: 19231982
35. Doebbeling BN, Reagan DR, Pfaller MA, Houston AK, Hollis RJ, Wenzel RP. Long-term efficacy of intranasal mupirocin ointment. A prospective cohort study of Staphylococcus aureus carriage. Arch Intern Med. 1994 Jul. 11; 154(13):1505-8. PMID: 8018006
36. Rahimian J, Khan R, La Scalea KA. Does nasal colonization or mupirocin treatment affect recurrence of methicillin-resistant Staphylococcus aureus skin and skin structure infections? Infect Control Hosp Epidemiol. 2007 Dec; 28(12):1415-6. PMID: 17952848
37. Ellis MW, Griffith ME, Dooley DP, McLean JC, Jorgensen JH, Patterson JE, et al. Targeted intranasal mupirocin to prevent colonization and infection by community-associated methicillin-resistant Staphylococcus aureus strains in soldiers: a cluster randomized controlled trial. Antimicrob Agents Chemother. 2007 Oct; 51(10):3591-8. PMID: 17682105
38. Datta R, Huang SS. Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis. 2008 Jul. 15; 47(2):176-81. doi: 10.1086/589241 PMID: 18532892
39. Lee LK, Win MK, Veeraraghavan MA, Wong CS, Chow AL, Leo YS. Short communication: risk factors for methicillin-resistant Staphylococcus aureus colonization among HIV patients at hospital admission. AIDS Res Hum Retroviruses. 2013 May; 29(5):796-8. doi: 10.1089/AID.2012.0074 PMID: 23517521
40. Padoveze MC, De Jesus Pedro R, Blum-Menezes D, Bratfich OJ, Moretti ML. Staphylococcus aureus nasal colonization in HIV outpatients: persistent or transient? Am J Infect Control. 2008 Apr; 36(3):187-91. doi: 10.1016/j.ajic.2007.05.012 PMID: 18371514
41. Madariaga MG, Ullrich F, Swindells S. Low prevalence of community-acquired methicillin-resistant Staphylococcus aureus colonization and apparent lack of correlation with sexual behavior among HIVinfected patients in Nebraska. Clin Infect Dis. 2009 May 15; 48(10):1485-7. doi: 10.1086/598511 PMID: 19374564
42. Hidron AI, Moanna A, Rimland D. The rise and fall of MRSA infections in HIV patients. AIDS 2001;25:1001-3. doi: 10.1097/QAD.0b013e328343c595 PMID: 21330913
43. Nouwen JL, Ott A, Kluytmans-Vandenbergh MF, Boelens HA, Hofman A, Van Belkum A, et al. Predicting the Staphylococcus aureus nasal carrier state: derivation and validation of a "culture rule". Clin Infect Dis. 2004 Sep. 15; 39(6):806-11. PMID: 15472812