Efficacy and safety of traditional Chinese medicine for the treatment of influenza A (H1N1): A meta-analysis

Journal of the Chinese Medical Association

Volumn 79, Issue 5, 2016, Pages 281-291

  Li, Jiang Hong ^a   Wang, Re Qin ^a   Guo, Wen Jie ^b   Li, Juan Sheng ^c  

^a Tianshui City Center for Disease Control   (China)

^b CHENGDU UNIVERSITY   (China)

^c LANZHOU UNIVERSITY   (China)

Author keywords

Influenza A (H1N1); Meta analysis; Traditional Chinese medicine; Treatment

Indexed keywords

HERBACEOUS AGENT; OSELTAMIVIR;

ANTIVIRAL THERAPY; ARTICLE; CHINESE MEDICINE; DRUG EFFICACY; DRUG SAFETY; HUMAN; INFLUENZA A (H1N1); INFLUENZA A VIRUS (H1N1); JADAD SCORE; META ANALYSIS; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; SIDE EFFECT; SYSTEMATIC REVIEW; VIRUS SHEDDING; WESTERN MEDICINE; ADULT; ADVERSE EFFECTS; FEMALE; INFLUENZA, HUMAN; MALE; MIDDLE AGED; VIROLOGY;

ADULT; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MALE; MEDICINE, CHINESE TRADITIONAL; MIDDLE AGED; VIRUS SHEDDING;

EID: 84959237099     PISSN: 17264901     EISSN: 17287731     Source Type: Journal    
DOI: 10.1016/j.jcma.2015.10.009     Document Type: Article

References (44)

1. Narain J.P., Bhatia R. Influenza A (H1N1): responding to a pandemic threat. Indian J Med Res 2009, 129:465-467.
2. World Health Organization DG statement following the meeting of the Emergency Committee 2009, World Health Organization, Geneva, Switzerland, Available from:, [Last accessed June 11, 2014]. http://www.who.int/csr/disease/swineflu/4th_meeting_ihr/en/index.htm.
3. Centers for Disease Control and Prevention (CDC) Swine influenza A (H1N1) infection in two children-Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep 2009, 58:400-402.
4. World Health Organization Pandemic (H1N1) 2009-update 84 2009, World Health Organization, Geneva, Switzerland, Available from:, [Last accessed November 15, 2014]. http://www.who.int/csr/don/2010_01_22/en/index.html.
5. Moscona A. Oseltamivir resistance-disabling our influenza defenses. N Engl J Med 2005, 353:2633-2636.
6. Higgins J.P.T., Green S. Cochrane handbook for systematic reviews of interventions version 5.0.2 [updated September 2009] 2008, Available from:, [Last accessed November 15, 2014]. http://www.cochrane-handbook.org.
7. Zhang T.S., Zhong W.Z. Practical evidence-based medicine methodology 2012, 57. Central South University Press, Changsha city, Hunan Province, China.
8. Chen H., Zeng Y.L., Liu D.F., Liu Y.L., Ye Q., Li L.H., et al. The stochastically control investigation of oseltamivir and Chinese traditional medicine in treating influenza A/H1N1. Si Chuan Med J 2010, 31:1050-1052.
9. OuYang H.X., Tang Q.X., Chen Y.H., Wei Y., Li G.S. Clinical observation of Lianhuaqingwen capsules in treatment of the influenza A/H1N1. China Med Herald 2010, 7:6-8.
10. Duan Z.P., Jia Z.H., Zhang J., Liu S., Chen R., Liang L.C., et al. Natural herbal medicine Lianhua-qingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial. Chin Med J 2011, 24:2925-2933.
11. Zeng Y.L., Liu D.F., Liu Y.L., Chen H., Bai Y., Wen X.M., et al. The randomized controlled trial on the efficacy and safety of modified maxingshigan decoction in treatment of the light influenza A pandemic H1N1 in Sichuan. Mod Prev Med 2011, 38:2227-2239.
12. Chen D.Q., Xu R., Wen X.M., Chen S.H., Zeng Y.L., Ye Q., et al. A prospective, randomized controlled trial of Chinese traditional medicine on treating the mild pandemic (H1N1) 2009 influenza in Sichuan area. Chin J Exp Clin Infect Dis (Electronic Edition) 2011, 5:278-286.
13. Influenza A. (H1N1) diagnosis and treatment program (third edition, 2009). Chin J Tradit Chin Med 2009, 21. 502, 543, 559, 564.
14. Chen F., Song K., Zhu X.H., Cheng H. The clinic study of H1Nl influenza virus with Fanggan granule. J Zhejiang Univ Tradit Chin Med 2010, 34:658-660.
15. Liu G.X., Zhang Y.X., Yang J.Q., Gao Z.Q., Meng Y.C.H. The randomized controlled study of Lianhuaqingwen capsule in treating influenza. Chin J Diffic and Compl Cas 2010, 1:14-16.
16. Xiao D., Tan Y.X., Chen C., Cao K., Hu W.Q., Pan J.H., et al. Clinical observation of Tian-Long compound on influenza A. Chin J Exp Tradit Med Formulae 2014, 20:171-174.
17. Zhao J.W., Zhu X.W., Zhou S.L., Wen L.Z.H., Zheng X.W., Song L.G., et al. Twenty six cases of alpha H1N1 influenza treated by combined therapy of integrative traditional Chinese and western medicine. J Anhui TCM Coll 2011, 30:19-20.
18. Han Y.F. Influenza A H1N1 influenza clinical observation of 144 cases Sang Ju Yin joint Yanhuning treatment. Chin J Tradit Chin Med 2011, 22:417-418.
19. Ma Y.P., Guo Y.L., Kang L., Zhao L., Peng J., Luo G.Y. Clinical study of Chinese herbs for the treatment of A/H1N1 influenza. ShanXi J Trad Chin Med 2010, 31:1351-1353.
20. Tang N.X., Ou J., Liu Y.Y., Li S.Z., Zhu G.H. Self-made soup adults with mild detoxification through clinical observation of treatment of H1N1 influenza. Guangxi J Tradit Chin Med 2013, 2:15-16.
21. Zheng H.J., Dai E.H., Zhang Z.Q., Li J.S., Wu L., Ning G.X., et al. Clinical study of 52 JuLa Qingdu decoction in the treatment of mild influenza A H1N1 to 52 patients. HeBei J Tradit Chin Med 2010, 32:1621-1622.
22. Liu Y.X., Zeng Z.Y., Fu B. Observation of modified Yinqiao decoction on influenza A virus respiratory tract infection. J Emerg Tradit Chin Med 2012, 21:451-453.
23. Liu D.F., Liu Y.L., Chen H., Zeng Y.L., Wen X.M., Ye Q., et al. Evaluation on the curative effect and safety of Chinese traditional medicine in treatment of mild A/H1N1 influenza in Sichuan area. Mod Prev Med 2011, 38:338-343.
24. Zhang W.S., He C.S., Wang Y.L. Clinical study on prescription of Chinese medicine administration in Sichuan Province in treating H1N1 influenza A. Gansu J TCM 2011, 24:20-22.
25. Zhang Z.F. Clinical observation of influenza A (H1N1) and suspected cases treated with integrated Chinese and Western medicine. World J Integr Tradit Western Med 2011, 6:572-586.
26. Zhao J.R., Wang S.H., Fan Y.S., Lou J.C., Li Z.Q., Wang J. Traditional Chinese medicine therapy for mild patients with influenza A (H1N1). Infect Dis Info 2011, 24:46-48.
27. Zhang A.M., Tan X.H., Mao H.J. Treatment of mild influenza A virus (HIN1) patients with traditional Chinese medicine. China Trop Med 2012, 12:1237-1239. 1242.
28. Wang C., Cao B., Liu Q.Q., Zou Z.Q., Liang Z.A., Cu L., et al. Oseltamivir compared with the Chinese traditional therapy maxingshigan-yinqiaosan in the treatment of H1N1 influenza a randomized trial. Ann Intern Med 2011, 155:217-225.
29. Dou A.H., Li T.S., Liu Z.Y., Yu F., OuYang Y., Zhang C.H., et al. Curative effect of oseltamivir combined with traditional Chinese medicine on type A H1N1 influenza. Mod J Integr Tradit Chin Western Med 2010, 19:3289-3290.
30. Wei Q., Luo H. Clinical study of Lianhuaqingwen capsule combined with oseltamivir in the treatment of mild influenza A H1N1 influenza treatment efficacy. Guangming J Chin Med 2010, 25:2318-2319.
31. Zhang Q.H., Li C., Wu J.H., Xiao M.M., Sun Y. Clinical observation of Lianhuaqingwen capsule combined with jinqiaomai tablet in influenza A/HINl. J Emerg Tradit Chin Med 2012, 21:345-346.
32. Weng B.X., Cai Y., Lu J. Clinical study of qjiehuashi decoction for A/H1N1 influenza on 150 patients. Int Med Health Guid News 2010, 16:979-980.
33. Geng L.M., Yu X.Y. Analysis of 38 influenza HINl infected cases treated with Chinese medicine cupping Lianhuaqingwen joint capsule. HeBei J Tradit Chin Med 2011, 33:753-754.
34. Tu B., Nie W.M., Ding P.P., Li F.G., Chen W.W., Zhou Z.P., et al. Efficacy of treatment of influenza A (H1N1) with oseltamivir phosphate and Isatis root granules. Med J Chin People's Armed Police Forces 2013, 24:465-470.
35. Tian G., Wang J., Kang L.H., Yang H.Q. Clinical study of Qingkailing oral liquid for A/H1N1 influenza. Chin J Inform TCM 2011, 18:81,112.
36. Li G. Observation of Tanreqing injection combined with oseltamivir influenza A(HINI). J Emerg Tradit Chin Med 2010, 19:1681-1682.
37. Chai L.X., Sun D., Ma Q.M., Gou H.H., Zhang J. Clinical observation of curative effect of Chinese herbs for the treatment influenza A (H1N1). Clin J Chin Med 2010, 36-37.
38. Qian J., Xu J.R., Shi L.Q. Clinical study of Tanreqing injection oseltamivir treatment of influenza H1N1 efficacy of influenza. Jilin Med 2011, 32:265-267.
39. Kjaergard L.L., Villumsen J., Gluud C. Reported methodological quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 2001, 135:982-989.
40. Moher D., Hopewell S., Schulz K.F., Montori V., Gøtzsche P.C. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomized trial. Int J Surg 2012, 10:28-55.
41. Dyex C. Gynaecologist banned in Canada appears before GMC. BMJ 2000, 320:1623.
42. Melchart D., Linde K., Weidenhammer W., Hager S., Shaw D., Baver R. Liver enzyme elevations in patients treated with traditional Chinese medicine. JAMA 1999, 282:28-29.
43. Jiang L., Deng L., Wu T. Chinese medicinal herbs for influenza. Cochrane Database Syst Rev 2013, 3:CD004559.
44. Zhao W.N., Lu F.G., Zhang W., Zhu Y.W., He Y.C. Effect of maxing Shigan decoction and its alteration on mice T-cell subpopulation exposed to influenza virus A. Pract Preven Med 2007, 2:278-280.