A novel, sporicidal formulation of ethanol for glove decontamination to prevent clostridium difficile hand contamination during glove removal

Infection Control and Hospital Epidemiology

Volumn 37, Issue 3, 2015, Pages 337-339

  Tomas, Myreen E ^a   Nerandzic, Michelle M ^a   Cadnum, Jennifer L ^b   Mana, Thriveen S C ^b   Jencson, Annette ^a   Sunskesula, Venkata ^b   Kundrapu, Sirisha ^b   Wilson, Brigid M ^a   Donskey, Curtis J ^a,b  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; CLOTHING; CONTAMINATION; GLOVE; HAND WASHING; HEALTH CARE PERSONNEL; PEPTOCLOSTRIDIUM DIFFICILE; RESPIRATORY TRACT DISEASE; STAINING; WASTE MANAGEMENT; BACTERIAL SPORE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DRUG EFFECTS; HAND; HUMAN; MICROBIOLOGY; PROCEDURES; PROTECTIVE GLOVE;

ANTI-INFECTIVE AGENTS, LOCAL; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CROSS INFECTION; DECONTAMINATION; ETHANOL; GLOVES, PROTECTIVE; HAND; HEALTH PERSONNEL; HUMANS; SPORES, BACTERIAL;

EID: 84959211087     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1017/ice.2015.289     Document Type: Article

References (10)

1. Kundrapu S, Sunkesula V, Jury LA, Sitzlar BM, Donskey CJ. Daily disinfection of high-touch surfaces in isolation rooms to reduce contamination of healthcare workers’ hands. Infect Control Hosp Epidemiol 2012;33:1039-1042.
2. Landelle C, Verachten M, Legrand P, Girou E, Barbut F, Brun-Buisson C. Contamination of healthcare workers’ hands with Clostridium difficile spores after caring for patients with C. difficile infection. Infect Control Hosp Epidemiol 2014;35:10-15.
3. Arfons L, Ray AJ, Donskey CJ. Clostridium difficile infection among healthcare workers receiving antibiotic therapy. Clin Infect Dis 2005;40:1384-1385.
4. Hayden MK, Blom DW, Lyle EA, Moore CG, Weinstein RA. Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant Enterococcus or the colonized patients’ environment. Infect Control Hosp Epidemiol 2008;29:149-154.
5. Morgan DJ, Liang SY, Smith CL, et al. Frequent multidrugresistant Acinetobacter baumannii contamination of gloves, gowns, and hands of healthcare workers. Infect Control Hosp Epidemiol 2010;31:716-721.
6. Kundrapu S, Sunkesula V, Jury I, Deshpande A, Donskey CJ. A randomized trial of soap and water hand wash versus alcohol hand rub for removal of Clostridium difficile spores from hands of patients. Infect Control Hosp Epidemiol 2014;35:204-206.
7. Tomas ME, Kundrapu S, Thota P, et al. Contamination of the skin and clothing of healthcare personnel during removal of personal protective equipment [published online October 12, 2015]. JAMA Intern Med 2015.
8. Tomas ME, Sunkesula VCK, Kundrapu S, Wilson BM, Donskey CJ. An intervention to reduce healthcare personnel hand contamination during care of patients with Clostridium difficile infection. Am J Infect Control. In press.
9. Nerandzic MM, Sunkesula VCK, Sankar T, Setlow P, Donskey CJ. Unlocking the sporicidal potential of ethanol: induced sporicidal activity of ethanol against Clostridium difficile and Bacillus spores under altered physical and chemical conditions. PLOS ONE 2015;10:e0132805.
10. Nerandzic MM, Sankar T, Setlow P, Donskey CJ. A cumulative spore killing approach: synergistic sporicidal activity of dilute peracetic acid and ethanol at low pH against Clostridium difficile and Bacillus subtilis spores. Open Forum Infect Dis. In press.