Which intraprocedural thrombotic events impact clinical outcomes after percutaneous coronary intervention in acute coronary syndromes? A pooled analysis of the HORIZONS-AMI and ACUITY trials

JACC: Cardiovascular Interventions

Volumn 9, Issue 4, 2016, Pages 331-337

  Wessler, Jeffrey D ^a   Généreux, Philippe ^a,b,c   Mehran, Roxana ^b,d   Ayele, Girma Minalu ^b   Brener, Sorin J ^b,e   McEntegart, Margaret ^f   Ben Yehuda, Ori ^a,b   Stone, Gregg W ^a,b   Kirtane, Ajay J ^a,b  

^a New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^b CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

^c HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e NEW YORK METHODIST HOSPITAL   (United States)

^f GOLDEN JUBILEE NATIONAL HOSPITAL   (United Kingdom)

Author keywords

acute coronary syndrome(s); intraprocedural thrombotic event(s); percutaneous coronary intervention

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; HIRULOG;

ACUTE CORONARY SYNDROME; ADULT; ADVERSE OUTCOME; AGED; ARTICLE; CONTROLLED STUDY; CORE LABORATORY; FEMALE; HEART DISEASE; HUMAN; INCIDENCE; INTRAPROCEDURAL STENT THROMBOSIS; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; ADVERSE EFFECTS; CHI SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY THROMBOSIS; DEVICES; DIAGNOSTIC IMAGING; HEMORRHAGE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; RISK FACTOR; STENT; TIME FACTOR; TREATMENT OUTCOME;

ACUTE CORONARY SYNDROME; AGED; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY THROMBOSIS; FEMALE; HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PROPORTIONAL HAZARDS MODELS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; RISK FACTORS; STENTS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84958944110     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2015.10.049     Document Type: Article

References (27)

1. T. Bauer, H. Mollmann, F. Weidinger, and et al. Predictors of hospital mortality in the elderly undergoing percutaneous coronary intervention for acute coronary syndromes and stable angina Int J Cardiol 151 2011 164 169
2. P. Fefer, A. Daoulah, B.H. Strauss, R. Chisholm, J.D. Sparkes, and A. Segev Visible angiographic complications predict short and long-term outcomes in patients with post-procedural creatine-phosphokinase elevation Catheter Cardiovasc Interv 76 2010 960 966
3. G.W. Stone, J.W. Moses, S.G. Ellis, and et al. Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents N Engl J Med 356 2007 998 1008
4. M.L. Fokkema, P.J. Vlaar, T. Svilaas, and et al. Incidence and clinical consequences of distal embolization on the coronary angiogram after percutaneous coronary intervention for ST-elevation myocardial infarction Eur Heart J 30 2009 908 915
5. A.J. Kirtane, P. Sandhu, R. Mehran, and et al. Association between intraprocedural thrombotic events and adverse outcomes after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (a Harmonizing Outcomes With RevasculariZatiON and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Substudy) Am J Cardiol 113 2014 36 43
6. P. Genereux, G.W. Stone, R.A. Harrington, and et al. Impact of intraprocedural stent thrombosis during percutaneous coronary intervention: insights from the CHAMPION PHOENIX Trial (Clinical Trial Comparing Cangrelor to Clopidogrel Standard of Care Therapy in Subjects Who Require Percutaneous Coronary Intervention) J Am Coll Cardiol 63 2014 619 629
7. M.B. McEntegart, A.J. Kirtane, E. Cristea, and et al. Intraprocedural thrombotic events during percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes are associated with adverse outcomes: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial J Am Coll Cardiol 59 2012 1745 1751
8. D. Brosh, A.R. Assali, A. Mager, and et al. Effect of no-reflow during primary percutaneous coronary intervention for acute myocardial infarction on six-month mortality Am J Cardiol 99 2007 442 445
9. J.P. Henriques, F. Zijlstra, J.P. Ottervanger, and et al. Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction Eur Heart J 23 2002 1112 1117
10. R.H. Mehta, K.J. Harjai, D. Cox, and et al. Clinical and angiographic correlates and outcomes of suboptimal coronary flow inpatients with acute myocardial infarction undergoing primary percutaneous coronary intervention J Am Coll Cardiol 42 2003 1739 1746
11. G. Ndrepepa, K. Tiroch, M. Fusaro, and et al. 5-year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction J Am Coll Cardiol 55 2010 2383 2389
12. K. Suenari, N. Shiode, K. Shirota, and et al. Predictors and long-term prognostic implications of angiographic slow/no-flow during percutaneous coronary intervention for acute myocardial infarction Intern Med 47 2008 899 906
13. S.J. Brener, E. Cristea, A.J. Kirtane, and et al. Intra-procedural stent thrombosis: a new risk factor for adverse outcomes in patients undergoing percutaneous coronary intervention for acute coronary syndromes J Am Coll Cardiol Intv 6 2013 36 43
14. Y.B. Pride, S. Mohanavelu, C. Zorkun, and et al. Association between angiographic complications and clinical outcomes among patients with acute coronary syndrome undergoing percutaneous coronary intervention: an EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndrome) angiographic substudy J Am Coll Cardiol Intv 5 2012 927 935
15. G.W. Stone, B.T. McLaurin, D.A. Cox, and et al. Bivalirudin for patients with acute coronary syndromes N Engl J Med 355 2006 2203 2216
16. G.W. Stone, B. Witzenbichler, G. Guagliumi, and et al. Bivalirudin during primary PCI in acute myocardial infarction N Engl J Med 358 2008 2218 2230
17. G.W. Stone, M. Bertrand, A. Colombo, and et al. Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: study design and rationale Am Heart J 148 2004 764 775
18. R. Mehran, B. Brodie, D.A. Cox, and et al. The Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial: study design and rationale Am Heart J 156 2008 44 56
19. C.M. Gibson, C.P. Cannon, W.L. Daley, and et al. TIMI frame count: a quantitative method of assessing coronary artery flow Circulation 93 1996 879 888
20. G.W. Stone, M.A. Peterson, A.J. Lansky, G. Dangas, R. Mehran, and M.B. Leon Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction J Am Coll Cardiol 39 2002 591 597
21. G. Sianos, M.I. Papafaklis, and P.W. Serruys Angiographic thrombus burden classification in patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention J Invasive Cardiol 22 2010 6B 14B
22. C.M. Gibson, C.P. Cannon, S.A. Murphy, S.J. Marble, H.V. Barron, and E. Braunwald Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction Circulation 105 2002 1909 1913
23. K. Isaaz, C. Robin, A. Cerisier, and et al. A new approach of primary angioplasty for ST-elevation acute myocardial infarction based on minimalist immediate mechanical intervention Coron Artery Dis 17 2006 261 269
24. S.H. Rezkalla, K.C. Dharmashankar, I.B. Abdalrahman, and R.A. Kloner No-reflow phenomenon following percutaneous coronary intervention for acute myocardial infarction: incidence, outcome, and effect of pharmacologic therapy J Interv Cardiol 23 2010 429 436
25. Q. Fu, W. Lu, Y.J. Huang, and et al. Verapamil reverses myocardial no-reflow after primary percutaneous coronary intervention in patients with acute myocardial infarction Cell Biochem Biophys 67 2013 911 914
26. O. Muller, C. Trana, and E. Eeckhout Myocardial no-reflow treatment Curr Vasc Pharmacol 11 2013 278 285
27. Y. Onuma, L. Thuesen, R.J. van Geuns, and et al. Randomized study to assess the effect of thrombus aspiration on flow area in patients with ST-elevation myocardial infarction: an optical frequency domain imaging study-TROFI trial Eur Heart J 34 2013 1050 1060