SIRS at Admission Is a Predictor of AKI Development and Mortality in Hospitalized Patients with Severe Alcoholic Hepatitis

Digestive Diseases and Sciences

Volumn 61, Issue 3, 2016, Pages 920-929

  Maiwall, R ^a   Chandel, S S ^a   Wani, Z ^a   Kumar, S ^b   Sarin, S K ^a  

^a INSTITUTE OF LIVER AND BILIARY SCIENCES   (India)

^b Department of Clinical Hematology   (India)

Author keywords

AKI; AKI progression; Severe alcoholic hepatitis; SIRS

Indexed keywords

PENTOXIFYLLINE;

ACUTE KIDNEY FAILURE; ADULT; ALCOHOL LIVER DISEASE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; SEVERE ALCOHOLIC HEPATITIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ACUTE KIDNEY INJURY; BACTERIAL INFECTIONS; END STAGE LIVER DISEASE; HEPATIC ENCEPHALOPATHY; HEPATITIS, ALCOHOLIC; HOSPITALIZATION; MIDDLE AGED; PERITONITIS; PNEUMONIA, BACTERIAL; PROGNOSIS; RISK FACTOR; SEVERITY OF ILLNESS INDEX; URINARY TRACT INFECTIONS;

ACUTE KIDNEY INJURY; ADULT; BACTERIAL INFECTIONS; COHORT STUDIES; DISEASE PROGRESSION; END STAGE LIVER DISEASE; FEMALE; HEPATIC ENCEPHALOPATHY; HEPATITIS, ALCOHOLIC; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; MORTALITY; PERITONITIS; PNEUMONIA, BACTERIAL; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; URINARY TRACT INFECTIONS;

EID: 84958914702     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-3921-4     Document Type: Article

References (23)

1. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med. 2009;360:2758–2769.
2. Mathurin P, O’Grady J, Carithers RL, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut. 2011;60:255–260.
3. Belcher JM, Garcia-Tsao G, Sanyal AJ, et al. Association of AKI with mortality and complications in hospitalized patients with cirrhosis. Hepatology. 2013;57:753–762.
4. Altamirano J, Fagundes C, Dominguez M, et al. Acute kidney injury is an early predictor of mortality for patients with alcoholic hepatitis. Clin Gastroenterol Hepatol. 2012;10:65–71.
5. Michelena J, Altamirano J, Abraldes JG, et al. Systemic inflammatory response and serum lipopolysaccharide levels predict multiple organ failure and death in alcoholic hepatitis. Hepatology. 2015;62:762–772.
6. Kubes P, Mehal WZ. Sterile inflammation in the liver. Gastroenterology. 2012;143:1158–1172.
7. Potts JR, Goubet S, Heneghan MA, Verma S. Determinants of long-term outcome in severe alcoholic hepatitis. Aliment Pharmacol Ther. 2013;38:584–595.
8. Dominguez M, Rincón D, Abraldes JG, et al. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am J Gastroenterol. 2008;103:2747–2756.
9. Wong F, Nadim MK, Kellum JA, et al. Working party proposal for a revised classification system of renal dysfunction in patients with cirrhosis. Gut. 2010;60:702–709.
10. American College of Chest Physicians/Society of Critical Care. Medicine Consensus. Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–874.
11. Angeli P, Tonon M, Pilutti C, Morando F, Piano S. Sepsis-induced acute kidney injury in patients with cirrhosis. Hepatol Int. 2015.
12. Barreto R, Fagundes C, Guevara M, et al. Type-1 hepatorenal syndrome associated with infections in cirrhosis: natural history, outcome of kidney function, and survival. Hepatology. 2014;59:1505–1513.
13. Rodríguez E, Elia C, Solà E, et al. Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis. J Hepatol. 2014;60:955–961.
14. Francoz C, Durand F. Type-1 hepatorenal syndrome in patients with cirrhosis and infection vs. sepsis-induced acute kidney injury: What matters? J Hepatol. 2014;60:907–909.
15. Shah N, Mohamed FE, Jover-Cobos M, et al. Increased renal expression and urinary excretion of TLR4 in acute kidney injury associated with cirrhosis. Liver Int. 2013;33:398–409.
16. Barreto R, Elia C, Solà E, Moreira R, Ariza X, Rodríguez E et al. Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections. J Hepatol. 2014. doi: 10.1016/j.jhep.2014.02.023
17. Louvet A, Wartel F, Castel H, et al. Infection in patients with severe alcoholic hepatitis treated with steroids: early response to therapy is the key factor. Gastroenterology. 2009;137:541–548.
18. Hmoud BS, Patel K, Bataller R, Singal AK. Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials. Liver Int. 2015. doi:10.1111/liv.12939.
19. Fagundes C, Barreto R, Guevara M, et al. A modified acute kidney injury classification for diagnosis and risk stratification of impairment of kidney function in cirrhosis. J Hepatol. 2013;59:474–481.
20. Thabut D, Massard J, Gangloff A, et al. Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure. Hepatology. 2007;46:1872–1882.
21. Thursz MR, Richardson P, Allison M, et al. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med. 2015;372:1619–1628.
22. Altamirano J, Miquel R, Katoonizadeh A, et al. A histologic scoring system for prognosis of patients with alcoholic hepatitis. Gastroenterology. 2014;146:1231-9.e1-6. doi:10.1053/j.gastro.2014.01.018.
23. Gao B, Shah VH. Combination therapy: New hope for alcoholic hepatitis? Clin Res Hepatol Gastroenterol. 2015. doi:10.1016/j.clinre.2015.05.008.