Treatment of autochthonous acute hepatitis E with short-term ribavirin: A multicenter retrospective study

Liver International

Volumn 36, Issue 3, 2016, Pages 328-333

  Péron, Jean Marie ^a   Abravanel, Florence ^b   Guillaume, Maeva ^a,c   Gérolami, René ^d   Nana, Jean ^a   Anty, Rodolphe ^e   Pariente, Alexandre ^f   Renou, Christophe ^g   Bureau, Christophe ^a   Robic, Marie Angèle ^a   Alric, Laurent ^a   Vinel, Jean pierre ^a   Izopet, Jacques ^b   Kamar, Nassim ^h  

^a CHU PURPAN   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

^c Université de Toulouse   (France)

^d HÔPITAL DE LA CONCEPTION   (France)

^e UNIVERSITY HOSPITAL OF NICE   (France)

^f CENTRE HOSPITALIER DE PAU   (France)

^g Centre Hospitalier Général de Hyères   (France)

^h CHU RANGUEIL   (France)

Author keywords

Acute hepatitis; Antiviral therapy; Cirrhosis; Hepatitis E; Immunodeficiency

Indexed keywords

METHOTREXATE; RIBAVIRIN; VIRUS RNA; ANTIVIRUS AGENT;

ACUTE HEPATITIS E; ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ANEMIA; ARTICLE; AUTOIMMUNE DISEASE; BLOOD SAMPLING; BRAIN DISEASE; CHEMOTHERAPY; CLINICAL ARTICLE; FEMALE; HEPATITIS E; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; MIDDLE AGED; PSORIATIC ARTHRITIS; RETROSPECTIVE STUDY; RISK FACTOR; SHORT COURSE THERAPY; TREATMENT DURATION; TREATMENT RESPONSE; ACUTE DISEASE; BLOOD; CLINICAL TRIAL; DRUG ADMINISTRATION; DRUG EFFECTS; FRANCE; GENETICS; GENOTYPE; HEPATITIS E VIRUS; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; MORTALITY; MULTICENTER STUDY; OPPORTUNISTIC INFECTIONS; RECURRENT DISEASE; REMISSION; SEVERITY OF ILLNESS INDEX; TIME FACTOR; TREATMENT OUTCOME; VERY ELDERLY; VIRUS LOAD;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FRANCE; GENOTYPE; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED; OPPORTUNISTIC INFECTIONS; RECURRENCE; REMISSION INDUCTION; RIBAVIRIN; RNA, VIRAL; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; VIRAL LOAD;

EID: 84958912427     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12911     Document Type: Article

References (16)

1. Kamar N, Bendall R, Legrand-Abravanel F, et al. Hepatitis E. Lancet 2012; 379: 2477-88.
2. Wedemeyer H, Pischke S, Manns MP. Pathogenesis and treatment of hepatitis e virus infection. Gastroenterology 2012; 142: 1388-1397 e1381.
3. Dalton HR, Fellows HJ, Stableforth W, et al. The role of hepatitis E virus testing in drug-induced liver injury. Aliment Pharmacol Ther 2007; 26: 1429-35.
4. Davern TJ, Chalasani N, Fontana RJ, et al. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology 2011; 141: 1665-1672 e1661-1669.
5. Peron JM, Bureau C, Poirson H, et al. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J Viral Hepat 2007; 14: 298-303.
6. Kamar N, Garrouste C, Haagsma EB, et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 2011; 140: 1481-9.
7. Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 2008; 358: 811-7.
8. Kamar N, Izopet J, Tripon S, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med 2014; 370: 1111-20.
9. Tavitian S, Peron JM, Huynh A, et al. Hepatitis E virus excretion can be prolonged in patients with hematological malignancies. J Clin Virol 2010; 49: 141-4.
10. Gerolami R, Borentain P, Raissouni F, et al. Treatment of severe acute hepatitis E by ribavirin. J Clin Virol 2011; 52: 60-2.
11. Goyal R, Kumar A, Panda SK, Paul SB, Acharya SK. Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: a preliminary report. Antivir Ther 2012; 17: 1091-6.
12. Peron JM, Dalton H, Izopet J, Kamar N. Acute autochthonous hepatitis E in western patients with underlying chronic liver disease: a role for ribavirin? J Hepatol 2011; 54: 1323-4; author reply 1324-1325.
13. Abravanel F, Sandres-Saune K, Lhomme S, et al. Genotype 3 diversity and quantification of hepatitis E virus RNA. J Clin Microbiol 2012; 50: 897-902.
14. Legrand-Abravanel F, Mansuy JM, Dubois M, et al. Hepatitis E virus genotype 3 diversity, France. Emerg Infect Dis 2009; 15: 110-4.
15. Peron JM, Mansuy JM, Poirson H, et al. Hepatitis E is an autochthonous disease in industrialized countries. Analysis of 23 patients in South-West France over a 13-month period and comparison with hepatitis A. Gastroenterol Clin Biol 2006; 30: 757-62.
16. Mansuy JM, Huynh A, Abravanel F, et al. Molecular evidence of patient-to-patient transmission of hepatitis E virus in a hematology ward. Clin Infect Dis 2009; 48: 373-4.