Racecadotril for acute diarrhoea in children: Systematic review and meta-analyses

Archives of Disease in Childhood

Volumn 101, Issue 3, 2016, Pages 234-240

  Gordon, Morris ^a,b   Akobeng, Anthony ^c,d  

^a BLACKPOOL VICTORIA HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^c SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETORPHAN; AMINOTRANSFERASE; KAOLIN PECTIN; LOPERAMIDE; PLACEBO; ANTIDIARRHEAL AGENT; THIORPHAN;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ABSENCE OF SIDE EFFECTS; ACUTE DIARRHEA; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHILDHOOD DISEASE; CONSTIPATION; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; HUMAN; META ANALYSIS; METHODOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; SIDE EFFECT; SYSTEMATIC ERROR; SYSTEMATIC REVIEW; VOMITING; ACUTE DISEASE; ANALOGS AND DERIVATIVES; CHILD; DIARRHEA; TREATMENT OUTCOME;

ACUTE DISEASE; ANTIDIARRHEALS; CHILD; DIARRHEA; HUMANS; THIORPHAN; TREATMENT OUTCOME;

EID: 84958836971     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/archdischild-2015-309676     Document Type: Article

References (30)

1. Sands R, Shanmugavadivel D, Stephenson T, et al. Medical problems presenting to paediatric emergency departments 10 years on. Emerg Med J 2012;29: 379-82.
2. Gill PJ, Goldacre MJ, Mant D, et al. Increase in emergency admissions to hospital for children aged under 15 in England, 1999-2010: National database analysis. Arch Dis Child 2013;98:328-34.
3. Nataro JP. Diarrhea among children in developing countries. Adv Exp Med Biol 2013;764:73-80.
4. Bruzzese E, Lo Vecchio A, Guarino A. Hospital management of children with acute gastroenteritis. Curr Opin Gastroenterol 2013;29:23-30.
5. Freedman SB, Sivabalasundaram V, Bohn V, et al. The treatment of pediatric gastroenteritis: A comparative analysis of pediatric emergency physicians' practice patterns. Acad Emerg Med 2011;18:38-45.
6. Riddle MS, Arnold S, Tribble DR. Effect of adjunctive loperamide in combination with antibiotics on treatment outcomes in traveler's diarrhea: A systematic review and meta-analysis. Clin Infect Dis 2008;47:1007-14.
7. Eberlin M, Mück T, Michel MC. A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. Front Pharmacol 2012;3:93.
8. Szajewska H, Ruszczy?ski M, Chmielewska A, et al. Systematic review: Racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther 2007;26:807-13.
9. Lehert P, Chéron G, Calatayud GA, et al. Racecadotril for childhood gastroenteritis: An individual patient data meta-analysis. Dig Liver Dis 2011;43:707-13.
10. Pitkin RM, Branagan MA, Burmeister LF. Accuracy of data in abstracts of published research articles. JAMA 1999;281:1110-1.
11. Higgins JPT, Altman DG, Sterne JAC. Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). Chapter 8. The Cochrane Collaboration, 2011. http://http://www.cochrane-handbook.org
12. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
13. Alam NH, Ashraf H, Khan WA, et al. Efficacy and tolerability of racecadotril in the treatment of cholera in adults: A double blind, randomised, controlled clinical trial. Gut 2003;52:1419-23.
14. Alvarez Calatayud G, Pinel G, et al. Efectividad de racecadotrilo en el tratamiento de la gastroenteritis aguda. Acta Pediatr Esp 2009;67:177-22. http://static. vademecum.es/documentos/evidencia/tiorfan/AlvarezCalatayud.AnPediatr.pdf
15. Cojocaru B, Bocquet N, Timsit S, et al. Effet du racécadotril sur le recours aux soins dans le traitement des diarrhées aiguës du nourrisson et de l'enfant. Arch Pédiatr 2002;8:774-9.
16. Guarino A, Dupont C, Gorelov AV, et al. The management of acute diarrhea in children in developed and developing areas: From evidence base to clinical practice. Expert Opin Pharmacother 2012;13:17-26.
17. Huighebaert S, Awouters F, Tytgat GNJ. Racecadotril versus loperamide: Antidiarrheal research revisited. Dig Dis Sci 2003;48:239-50.
18. Mehta S, Khandelwal PD, Jain VK, et al. A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea. J Assoc Physicians India 2012;60:12-15.
19. Pie?cik-Lech M, Shamir R, Guarino A, et al. Review article: The management of acute gastroenteritis in children. Aliment Pharmacol Ther 2013;37:289-303.
20. Rao SG. Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children. J Indian Med Assoc 2002;100:530.
21. Rautenberg TA, Zerwes U, Foerster D, et al. Evaluating the cost utility of racecadotril for the treatment of acute watery diarrhea in children: The RAWD model. Clinicoecon Outcomes Res 2012;4:109-16.
22. Tebruegge M. Racecadotril did not improve diarrhoeal symptoms in children with moderate acute gastroenteritis. Arch Dis Child Educ Pract Ed 2010;95:197.
23. Tormo R, Polanco I, Salazar-Lindo E, et al. Acute infectious diarrhoea in children: New insights in antisecretory treatment with racecadotril. Acta Paediatr 2008;97:1008-15.
24. Savitha MR. Racecadotrial-a novel drug for treatment of acute watery diarrhoea in Indian children. Karnataka Pedicon 2005-Conference Abstracts. Pediatric Oncall [serial online]; 2006 (cited 1 January 2006):3. http://www.pediatriconcall.com/fordoctor/Conferenceabstracts/racecadotrial.asp
25. Cézard JP, Duhamel JF, Meyer M, et al. Efficacy and tolerability of racecadotril in acute diarrhea in children. Gastroenterology 2001;120:799-805.
26. Gutierrez Castrellon P, Polanco Allue I, Salazar Lindo E. An evidence based Iberic-Latin American guideline for acute gastroenteritis management in infants and prescholars (Manejo de la gastroenteritis aguda en menores de 5 anos: Un enfoque basado en la evidencia. Guia de practica clinical Ibero-Latinoamericana. An Pediatr (Barcelona) 2010;71:e1-220.e20.
27. Salazar-Lindo E, Santisteban-Ponce J, Chea-Woo E, et al. Racecadotril in the treatment of acute watery diarrhoea in children. N Engl J Med 2000;343:463-7.
28. Santos M, Marañón R, Miguez C, et al. Use of racecadotril as outpatient treatment for acute gastroenteritis: A prospective, randomised, parallel study. J Pediatr 2009;155:62-7.
29. Melendez Garcia JM, Rodriguez JT. Racecadotril en el tratamiento de la diarrea aguda en ninos. Revista de la Facultad de Medicina (Guatemala) 2007;4:25-8.
30. Turck D, Berard H, Fretault N, et al. Comparison of racecadotril and loperamide in children with acute diarrhoea. Aliment Pharmacol Ther 1999;13:27-32.