Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation

Neurogastroenterology and Motility

Volumn 28, Issue 6, 2016, Pages 861-870

  Lam, C ^a   Chaddock, G ^b   Marciani, L ^a   Costigan, C ^a   Paul, J ^b   Cox, E ^b   Hoad, C ^a,b   Menys, A ^c   Pritchard, S ^b   Garsed, K ^d   Taylor, S ^c   Atkinson, D ^c   Gowland, P ^b   Spiller, R ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d DERBY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Colon; Functional constipation; Irritable bowel syndrome with constipation; Laxative; Motility

Indexed keywords

LAXATIVE; MACROGOL DERIVATIVE; MOVIPREP;

ADULT; AGED; ARTICLE; ASCENDING COLON; CLINICAL ARTICLE; COLON; COLON DILATATION; COLON MOTILITY; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FUNCTIONAL CONSTIPATION; HUMAN; INGESTION; INTESTINE FUNCTION; INTESTINE TRANSIT TIME; IRRITABLE BOWEL SYNDROME WITH CONSTIPATION; IRRITABLE COLON; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OPEN STUDY; ORGAN SIZE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; WATER CONTENT; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DRUG EFFECTS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; MIDDLE AGED; PHYSIOLOGY; PROCEDURES;

ADULT; COLON; CONSTIPATION; FEMALE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HUMANS; IRRITABLE BOWEL SYNDROME; LAXATIVES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS;

EID: 84958818492     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12784     Document Type: Article

References (28)

1. Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004; 99: 750-9.
2. Johanson JF, Kralstein J. Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther 2007; 25: 599-608.
3. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006; 130: 1480-91.
4. Wong RK, Palsson OS, Turner MJ, Levy RL, Feld AD, von Korff M, Whitehead WE. Inability of the Rome III criteria to distinguish functional constipation from constipation-subtype irritable bowel syndrome. Am J Gastroenterol 2010; 105: 2228-34.
5. Rao SS, Sadeghi P, Beaty J, Kavlock R. Ambulatory 24-hour colonic manometry in slow-transit constipation. Am J Gastroenterol 2004; 99: 2405-16.
6. Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B et al. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol 2009; 297: G1107-14.
7. Hoad CL, Marciani L, Foley S, Totman JJ, Wright J, Bush D, Cox EF, Campbell E et al. Non-invasive quantification of small bowel water content by MRI: a validation study. Phys Med Biol 2007; 52: 6909-22.
8. Pritchard SE, Marciani L, Garsed KC, Hoad CL, Thongborisute W, Roberts E, Gowland PA, Spiller RC. Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI. Neurogastroenterol Motil 2014; 26: 124-30.
9. Menys A, Hamy V, Makanyanga J, Hoad C, Gowland P, Odille F, Taylor SA, Atkinson D. Dual registration of abdominal motion for motility assessment in free-breathing data sets acquired using dynamic MRI. Phys Med Biol 2014; 59: 4603-19.
10. Chaddock G, Lam C, Hoad CL, Costigan C, Cox EF, Placidi E, Thexton I, Wright J et al. Novel MRI tests of orocecal transit time and whole gut transit time: studies in normal subjects. Neurogastroenterol Motil 2014; 26: 205-14.
11. Marciani L, Garsed KC, Hoad CL, Fields A, Fordham I, Pritchard SE, Placidi E, Murray K et al. Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose. Neurogastroenterol Motil 2014; 26: 1426-36.
12. Cremonini F, Mullan BP, Camilleri M, Burton DD, Rank MR. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther 2002; 16: 1781-90.
13. Metcalf AM, Phillips SF, Zinsmeister AR, MacCarty RL, Beart RW, Wolff BG. Simplified assessment of segmental colonic transit. Gastroenterology 1987; 92: 40-7.
14. O'Donnell LJ, Virjee J, Heaton KW. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. BMJ 1990; 300: 439-40.
15. Marciani L, Cox EF, Hoad CL, Pritchard S, Totman JJ, Foley S, Mistry A, Evans S et al. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Gastroenterology 2010; 138: 469-77, 77 e1.
16. Marciani L, Wright J, Foley S, Hoad CL, Totman JJ, Bush D, Hartley C, Armstrong A et al. Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2010; 32: 655-63.
17. Hoad CL, Menys A, Garsed K, Marciani L, Hamy V, Murray K, Costigan C, Atkinson D et al. Colon wall motility: comparison of novel quantitative semi-automatic measurements using cine MRI. Neurogastroenterol Motil. DOI: 10.1111/nmo.12727.
18. Hurst AF. Constipation and Allied Intestinal Disorders. London: Forgotten Books, 2013 (Original work published 1919).
19. Camilleri M, Hasler WL, Parkman HP, Quigley EM, Soffer E. Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology 1998; 115: 747-62.
20. Deiteren A, Camilleri M, Bharucha AE, Burton D, McKinzie S, Rao AS, Zinsmeister AR. Performance characteristics of scintigraphic colon transit measurement in health and irritable bowel syndrome and relationship to bowel functions. Neurogastroenterol Motil 2010; 22: 415-23, e95.
21. Dinning PG, Szczesniak MM, Cook IJ. Twenty-four hour spatiotemporal mapping of colonic propagating sequences provides pathophysiological insight into constipation. Neurogastroenterol Motil 2008; 20: 1017-21.
22. Rao SS, Kuo B, McCallum RW, Chey WD, DiBaise JK, Hasler WL, Koch KL, Lackner JM et al. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol 2009; 7: 537-44.
23. Cann PA, Read NW, Brown C, Hobson N, Holdsworth CD. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 1983; 24: 405-11.
24. Vassallo M, Camilleri M, Phillips SF, Brown ML, Chapman NJ, Thomforde GM. Transit through the proximal colon influences stool weight in the irritable bowel syndrome. Gastroenterology 1992; 102: 102-8.
25. Degen LP, Phillips SF. Variability of gastrointestinal transit in healthy women and men. Gut 1996; 39: 299-305.
26. Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, MacDougall JE, Jia XD et al. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol 2012; 107: 1702-12.
27. Rao S, Lembo AJ, Shiff SJ, Lavins BJ, Currie MG, Jia XD, Shi K, MacDougall JE et al. A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation. Am J Gastroenterol 2012; 107: 1714-24; quiz p. 25.
28. Probert CS, Emmett PM, Cripps HA, Heaton KW. Evidence for the ambiguity of the term constipation: the role of irritable bowel syndrome. Gut 1994; 35: 1455-8.