A cumulative genetic risk score predicts progression in Parkinson's disease

Movement Disorders

Volumn 31, Issue 4, 2016, Pages 487-490

  Pihlstrøm, Lasse ^a,b   Morset, Kristina Rebekka ^a   Grimstad, Espen ^a   Vitelli, Valeria ^c   Toft, Mathias ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

Genetics; GWAS; Hoehn and Yahr; Parkinson's disease; Progression

Indexed keywords

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC RISK SCORE; GENETIC SUSCEPTIBILITY; HIGH RISK PATIENT; HOEHN AND YAHR SCALE; HUMAN; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MOTOR PERFORMANCE; OUTCOME ASSESSMENT; PARKINSON DISEASE; PHENOTYPIC VARIATION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL; UNIFIED PARKINSON DISEASE RATING SCALE; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; PATHOPHYSIOLOGY; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; PARKINSON DISEASE; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL ANALYSIS;

EID: 84958818004     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26505     Document Type: Article

References (20)

1. Do CB, Tung JY, Dorfman E, et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet 2011;7:e1002141.
2. Nalls MA, Pankratz N, Lill CM, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 2014;46:989-993.
3. Kasten M, Klein C. Genetic risk loci for Parkinson's disease: Moving from state to trait? Mov Disord 2015;30:747-749.
4. Nalls MA, Escott-Price V, Williams NM, et al. Genetic risk and age in Parkinson's disease: Continuum not stratum. Mov Disord 2015;30:850-854.
5. Lill CM, Hansen J, Olsen JH, Binder H, Ritz B, Bertram L. Impact of Parkinson's disease risk loci on age at onset. Mov Disord 2015;30:847-850.
6. Escott-Price V, International Parkinson's Disease Genomics C, Nalls MA, et al. Polygenic risk of Parkinson disease is correlated with disease age at onset. Ann Neurol 2015;77:582-591.
7. Pihlstrom L, Toft M. Cumulative genetic risk and age at onset in Parkinson's disease. Mov Disord 2015; doi:10.1002/mds.26366.
8. Goetz CG, Poewe W, Rascol O, et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord 2004;19:1020-1028.
9. Movement Disorder Society Task Force on Rating Scales for Parkinson's D. The Unified Parkinson's Disease Rating Scale (UPDRS): status and recommendations. Mov Disord 2003;18:738-750.
10. Pihlstrom L, Axelsson G, Bjornara KA, et al. Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease. Neurobiol Aging 2013;34:1708 e1707-e1713.
11. Ritz B, Rhodes SL, Bordelon Y, Bronstein J. alpha-Synuclein genetic variants predict faster motor symptom progression in idiopathic Parkinson disease. PLoS One 2012;7:e36199.
12. Chung SJ, Biernacka JM, Armasu SM, et al. Alpha-synuclein repeat variants and survival in Parkinson's disease. Mov Disord 2014;29:1053-1057.
13. Chung SJ, Armasu SM, Biernacka JM, et al. Genomic determinants of motor and cognitive outcomes in Parkinson's disease. Parkinsonism Relat Disord 2012;18:881-886.
14. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-442.
15. Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP. Progression of motor impairment and disability in Parkinson disease: a population-based study. Neurology 2005;65:1436-1441.
16. Poewe W. The natural history of Parkinson's disease. J Neurol 2006;253(Suppl 7):VII2-VII6.
17. Yahalom G, Orlev Y, Cohen OS, et al. Motor progression of Parkinson's disease with the leucine-rich repeat kinase 2 G2019S mutation. Mov Disord 2014;29:1057-1060.
18. Winder-Rhodes SE, Evans JR, Ban M, et al. Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort. Brain 2013;136:392-399.
19. Lucking CB, Durr A, Bonifati V, et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med 2000;342:1560-1567.
20. Sato K, Hatano T, Yamashiro K, et al. Prognosis of Parkinson's disease: time to stage III, IV, V, and to motor fluctuations. Mov Disord 2006;21:1384-1395.