Mechanism of fine-tuning pH sensors in proprotein convertases: Identification of a pH-sensing histidine pair in the propeptide of proprotein convertase 1/3

Journal of Biological Chemistry

Volumn 290, Issue 38, 2015, Pages 23214-23225

  Williamson, Danielle M ^a   Elferich, Johannes ^a   Shinde, Ujwal ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; MICROCOMPUTERS; PH; PROTONATION;

COGNATE PROTEASE; CONVERTASES; FINE TUNING; ORGANELLAR COMPARTMENTS; PH-DEPENDENT; PROTEASE ACTIVATION; PROTON CONCENTRATIONS; SECRETORY PATHWAYS;

PH SENSORS;

HISTIDINE; PROPROTEIN CONVERTASE 1; SERINE PROTEINASE;

AMINO ACID ANALYSIS; ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; PROTON TRANSPORT; SEQUENCE ANALYSIS; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; PROPROTEIN CONVERTASE 1;

EID: 84958783143     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.665430     Document Type: Article

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