Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses

Cardiovascular Toxicology

Volumn 17, Issue 2, 2017, Pages 97-108

  Thompson, Leslie C ^a   Ledbetter, Allen D ^a   Haykal Coates, Najwa ^a   Cascio, Wayne E ^a   Hazari, Mehdi S ^a   Farraj, Aimen K ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Acrolein; Echocardiography; Myocardial dyssynchrony; Myocardial strain; Tei index

Indexed keywords

ACROLEIN; AIR POLLUTANT;

AIR POLLUTANT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY PLETHYSMOGRAPHY; CARDIOTOXICITY; CONTROLLED STUDY; EXPOSURE; HEART MUSCLE BLOOD FLOW; HEART PERFORMANCE; IN VIVO STUDY; LUNG VENTILATION; MALE; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PULSED DOPPLER ULTRASONOGRAPHY; SPECKLE TRACKING ECHOCARDIOGRAPHY; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COLOR DOPPLER ECHOCARDIOGRAPHY; DIAGNOSTIC IMAGING; DOSE RESPONSE; DRUG EFFECTS; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; LUNG; PATHOPHYSIOLOGY; PNEUMONIA; PULSED DOPPLER ECHOCARDIOGRAPHY; RISK ASSESSMENT; TIME FACTOR; TOXICITY;

ACROLEIN; AIR POLLUTANTS; ANIMALS; CARDIOTOXICITY; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHOCARDIOGRAPHY, DOPPLER, COLOR; ECHOCARDIOGRAPHY, DOPPLER, PULSED; INHALATION EXPOSURE; LUNG; MALE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; PLETHYSMOGRAPHY, WHOLE BODY; PNEUMONIA; PULMONARY VENTILATION; RISK ASSESSMENT; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 84958772872     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-016-9360-4     Document Type: Article

References (37)

1. Brook, R. D., Rajagopalan, S., Pope, C. A, 3rd, Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., et al. (2010). Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation, 121, 2331–2378.
2. Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., & Joshi-Barve, S. (2015). Molecular mechanisms of acrolein toxicity: Relevance to human disease. Toxicological Sciences, 143, 242–255.
3. EPA. (2003). Toxicological review of acrolein (CAS No. 107-02-8). Washington, DC: US Environmental Protection Agency.
4. ATSDR. (2007). Toxicological profile for acrolein. U.S: Department of Health and Human Services, Public Health Service, Atlanta, GA.
5. Haussmann, H. J. (2012). Use of hazard indices for a theoretical evaluation of cigarette smoke composition. Chemical Research in Toxicology, 25, 794–810.
6. DeJarnett, N., Conklin, D. J., Riggs, D. W., Myers, J. A., O’Toole, T. E., Hamzeh, I., et al. (2014). Acrolein exposure is associated with increased cardiovascular disease risk. Journal of the American Heart Association, 3, e000934. doi:10.1161/JAHA.114.000934.
7. Perez, C. M., Ledbetter, A. D., Hazari, M. S., Haykal-Coates, N., Carll, A. P., Winsett, D. W., et al. (2013). Hypoxia stress test reveals exaggerated cardiovascular effects in hypertensive rats after exposure to the air pollutant acrolein. Toxicological Sciences, 132, 467–477.
8. Hazari, M. S., Griggs, J., Winsett, D. W., Haykal-Coates, N., Ledbetter, A., Costa, D. L., & Farraj, A. K. (2014). A single exposure to acrolein desensitizes baroreflex responsiveness and increases cardiac arrhythmias in normotensive and hypertensive rats. Cardiovascular Toxicology, 14, 52–63.
9. Luo, J., Hill, B. G., Gu, Y., Cai, J., Srivastava, S., Bhatnagar, A., & Prabhu, S. D. (2007). Mechanisms of acrolein-induced myocardial dysfunction: Implications for environmental and endogenous aldehyde exposure. American Journal of Physiology Heart and Circulatory Physiology, 293, H3673–H3684.
10. Wang, L., Sun, Y., Asahi, M., & Otsu, K. (2011). Acrolein, an environmental toxin, induces cardiomyocyte apoptosis via elevated intracellular calcium and free radicals. Cell Biochemistry and Biophysics, 61, 131–136.
11. Wu, Z., He, E. Y., Scott, G. I., & Ren, J. (2015). Alpha, beta-unsaturated aldehyde pollutant acrolein suppresses cardiomyocyte contractile function: Role of TRPV1 and oxidative stress. Environmental Toxicology, 30, 638–647.
12. Stypmann, J., Engelen, M. A., Troatz, C., Rothenburger, M., Eckardt, L., & Tiemann, K. (2009). Echocardiographic assessment of global left ventricular function in mice. Laboratory Animals, 43, 127–137.
13. Dandel, M., Lehmkuhl, H., Knosalla, C., Suramelashvili, N., & Hetzer, R. (2009). Strain and strain rate imaging by echocardiography—Basic concepts and clinical applicability. Current Cardiology Reviews, 5, 133–148.
14. Thavendiranathan, P., Poulin, F., Lim, K. D., Plana, J. C., Woo, A., & Marwick, T. H. (2014). Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: A systematic review. Journal of the American College of Cardiology, 63, 2751–2768.
15. Tei, C., Ling, L. H., Hodge, D. O., Bailey, K. R., Oh, J. K., Rodeheffer, R. J., et al. (1995). New index of combined systolic and diastolic myocardial performance: A simple and reproducible measure of cardiac function—a study in normals and dilated cardiomyopathy. Journal of Cardiology, 26, 357–366.
16. Caro, A. C., Hankenson, F. C., & Marx, J. O. (2013). Comparison of thermoregulatory devices used during anesthesia of C57BL/6 mice and correlations between body temperature and physiologic parameters. Journal of the American Association for Laboratory Animal Science, 52, 577–583.
17. Jaskot, R. H., Charlet, E. G., Grose, E. C., Grady, M. A., & Roycroft, J. H. (1983). An automated analysis of glutathione peroxidase, S-transferase, and reductase activity in animal tissue. Journal of Analytical Toxicology, 7, 86–88.
18. Perez, C. M., Hazari, M. S., Ledbetter, A. D., Haykal-Coates, N., Carll, A. P., Cascio, W. E., et al. (2015). Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats. Inhalation Toxicology, 27, 54–63.
19. Shen, M. J., & Zipes, D. P. (2014). Role of the autonomic nervous system in modulating cardiac arrhythmias. Circulation Research, 114, 1004–1021.
20. Paton, J. F., Boscan, P., Pickering, A. E., & Nalivaiko, E. (2005). The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited. Brain Research. Brain Research Reviews, 49, 555–565.
21. Gimelli, A., Liga, R., Genovesi, D., Giorgetti, A., Kusch, A., & Marzullo, P. (2014). Association between left ventricular regional sympathetic denervation and mechanical dyssynchrony in phase analysis: A cardiac CZT study. European Journal of Nuclear Medicine and Molecular Imaging, 41, 946–955.
22. Schlack, W., Schafer, S., & Thamer, V. (1994). Left stellate ganglion block impairs left ventricular function. Anesthesia and Analgesia, 79, 1082–1088.
23. Schlack, W., & Thamer, V. (1996). Unilateral changes of sympathetic tone to the heart impair left ventricular function. Acta Anaesthesiologica Scandinavica, 40, 262–271.
24. Sequeira, I. M., Haberberger, R. V., & Kummer, W. (2005). Atrial and ventricular rat coronary arteries are differently supplied by noradrenergic, cholinergic and nitrergic, but not sensory nerve fibres. Annals of Anatomy, 187, 345–355.
25. Reant, P., Labrousse, L., Lafitte, S., Bordachar, P., Pillois, X., Tariosse, L., et al. (2008). Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions. Journal of the American College of Cardiology, 51, 149–157.
26. Winter, R., Jussila, R., Nowak, J., & Brodin, L. A. (2007). Speckle tracking echocardiography is a sensitive tool for the detection of myocardial ischemia: A pilot study from the catheterization laboratory during percutaneous coronary intervention. Journal of the American Society of Echocardiography, 20, 974–981.
27. Marwick, T. H. (2006). Measurement of strain and strain rate by echocardiography: Ready for prime time? Journal of the American College of Cardiology, 47, 1313–1327.
28. Lee, A. P., Zhang, Q., Yip, G., Fang, F., Liang, Y. J., Xie, J. M., et al. (2011). LV mechanical dyssynchrony in heart failure with preserved ejection fraction complicating acute coronary syndrome. JACC Cardiovascular Imaging, 4, 348–357.
29. Perez, C. M., Hazari, M. S., & Farraj, A. K. (2015). Role of autonomic reflex arcs in cardiovascular responses to air pollution exposure. Cardiovascular Toxicology, 15, 69–78.
30. Ghilarducci, D. P., & Tjeerdema, R. S. (1995). Fate and effects of acrolein. Reviews of Environmental Contamination and Toxicology, 144, 95–146.
31. Moretto, N., Volpi, G., Pastore, F., & Facchinetti, F. (2012). Acrolein effects in pulmonary cells: Relevance to chronic obstructive pulmonary disease. Annals of the New York Academy of Sciences, 1259, 39–46.
32. Pagel, P. S., Nijhawan, N., & Warltier, D. C. (1993). Quantitation of volatile anesthetic-induced depression of myocardial contractility using a single beat index derived from maximal ventricular power. Journal of Cardiothoracic and Vascular Anesthesia, 7, 688–695.
33. Hatakeyama, N., Ito, Y., & Momose, Y. (1993). Effects of sevoflurane, isoflurane, and halothane on mechanical and electrophysiologic properties of canine myocardium. Anesthesia and Analgesia, 76, 1327–1332.
34. Palmisano, B. W., Mehner, R. W., Stowe, D. F., Bosnjak, Z. J., & Kampine, J. P. (1994). Direct myocardial effects of halothane and isoflurane. Comparison between adult and infant rabbits. Anesthesiology, 81, 718–729.
35. Lairez, O., Lonjaret, L., Ruiz, S., Marchal, P., Franchitto, N., Calise, D., et al. (2013). Anesthetic regimen for cardiac function evaluation by echocardiography in mice: Comparison between ketamine, etomidate and isoflurane versus conscious state. Laboratory Animals, 47, 284–290.
36. Lynch, P. J., & Jaffe, C. C. (2006). Heart normal short axis section. New Haven, CT: Creative Commons.
37. Lynch, P. J., & Jaffe, C. C. (2006). Heart apical 4c anatomy. New Haven, CT: Creative Commons.