Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics

Angewandte Chemie - International Edition

Volumn 55, Issue 2, 2016, Pages 528-533

  Rashidian, Mohammad ^a   Wang, Lu ^b   Edens, Jerre G ^a   Jacobsen, Johanne T ^a   Hossain, Intekhab ^a   Wang, Qifan ^b   Victora, Gabriel D ^a   Vasdev, Neil ^b   Ploegh, Hidde ^a,c   Liang, Steven H ^b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

enzymes; isotopic labeling; PEGylation; positron emission tomography; single domain antibodies

Indexed keywords

ENZYMES; ISOTOPES; POSITRON EMISSION TOMOGRAPHY;

ANTIBODY FRAGMENT; IMAGING MODALITY; ISOTOPIC LABELING; PEGYLATION; PHARMACEUTICAL AGENTS; SINGLE-DOMAIN ANTIBODIES; THERAPEUTIC EFFICACY; TISSUE PENETRATIONS;

ANTIBODIES;

HLA ANTIGEN CLASS 2; NANOBODY;

ANIMAL; BLOOD; CELL CULTURE; CHEMISTRY; DIMERIZATION; EXPERIMENTAL MELANOMA; HALF LIFE TIME; IMMUNOLOGY; MOLECULAR IMAGING; MOUSE;

ANIMALS; CELLS, CULTURED; DIMERIZATION; HALF-LIFE; HISTOCOMPATIBILITY ANTIGENS CLASS II; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR IMAGING; SINGLE-DOMAIN ANTIBODIES;

EID: 84958752510     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201507596     Document Type: Article

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