Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression

Basic Research in Cardiology

Volumn 111, Issue 2, 2016, Pages 1-11

  Lindau, Alexandra ^a   Härdtner, Carmen ^a   Hergeth, Sonja P ^a   Blanz, Kelly Daryll ^a,b   Dufner, Bianca ^a   Hoppe, Natalie ^a   Anto Michel, Nathaly ^a   Kornemann, Jan ^a   Zou, Jiadai ^a   Gerhardt, Louisa M S ^a   Heidt, Timo ^a   Willecke, Florian ^a   Geis, Serjosha ^a   Stachon, Peter ^a   Wolf, Dennis ^a   Libby, Peter ^c   Swirski, Filip K ^d   Robbins, Clinton S ^e   McPheat, William ^f   Hawley, Shaun ^g   Braddock, Martin ^g   Gilsbach, Ralf ^b   Hein, Lutz ^b   von zur Mühlen, Constantin ^a   Bode, Christoph ^a   Zirlik, Andreas ^a   Hilgendorf, Ingo ^a   more..

^a UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f ASTRAZENECA R AND D   (Sweden)

^g ASTRAZENECA   (United Kingdom)

Author keywords

Atherosclerosis; Egress; Macrophages; Monocytes; Progenitors; Proliferation; SYK

Indexed keywords

APOLIPOPROTEIN E; FOSTAMATINIB; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; PROTEIN KINASE SYK; OXAZINE DERIVATIVE; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; SIGNAL PEPTIDE; SYK PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIOACCUMULATION; CELL ADHESION; CELL COUNT; CELL DIFFERENTIATION; CELL INFILTRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; INTRACELLULAR SIGNALING; MACROPHAGE; MACROPHAGE FUNCTION; MONOCYTE; MONOCYTOSIS; MOUSE; MYELOPOIESIS; NONHUMAN; TISSUE CHARACTERIZATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; COMPARATIVE STUDY; DISEASE COURSE; DRUG EFFECTS; IMMUNOLOGY; PRECLINICAL STUDY; RANDOMIZATION;

ANIMALS; ATHEROSCLEROSIS; CELL ADHESION; CELLS, CULTURED; DISEASE PROGRESSION; DRUG EVALUATION, PRECLINICAL; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; MONOCYTES; MYELOPOIESIS; OXAZINES; PROTEIN-TYROSINE KINASES; PYRIDINES; RANDOM ALLOCATION; SYK KINASE;

EID: 84958745184     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-016-0535-8     Document Type: Article

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