A study of common Mendelian disease carriers across ageing British cohorts: meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height

Journal of Medical Genetics

Volumn 53, Issue 4, 2016, Pages 280-288

  North, Teri Louise ^a   Ben Shlomo, Yoav ^a   Cooper, Cyrus ^b,c,d   Deary, Ian J ^e   Gallacher, John ^f   Kivimaki, Mika ^g   Kumari, Meena ^g,h   Martin, Richard M ^a   Pattie, Alison ^e   Sayer, Avan Aihie ^b   Starr, John M ^e   Wong, Andrew ^g   Kuh, Diana ^g   Rodriguez, Santiago ^a   Day, Ian N M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ALPHA 1 ANTITRYPSIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HIGH MOBILITY GROUP A2 PROTEIN; SERPINA1 PROTEIN, HUMAN;

ADULT; AGED; AGING; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; BRITISH CITIZEN; CHRONIC OBSTRUCTIVE LUNG DISEASE; COGNITIVE AGING; COHORT ANALYSIS; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE MUTATION; GENOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE DEFICIENCY; META ANALYSIS; PHENYLKETONURIA; PHYSICAL CAPACITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM; ALLELE; ALPHA 1-ANTITRYPSIN DEFICIENCY; CYSTIC FIBROSIS; EUROPE; FEMALE; GENETIC POLYMORPHISM; GENETICS; HETEROZYGOTE; MALE; PATHOLOGY; PHENOTYPE; PHENYLKETONURIAS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

ALLELES; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; CYSTIC FIBROSIS; EUROPE; FEMALE; FORCED EXPIRATORY VOLUME; GENOTYPE; HETEROZYGOTE; HMGA2 PROTEIN; HUMANS; MALE; PHENOTYPE; PHENYLKETONURIAS; POLYMORPHISM, GENETIC; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE;

EID: 84958672558     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmedgenet-2015-103342     Document Type: Article

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