Serum uric acid levels and risk of metabolic syndrome: A dose-response meta-analysis of prospective studies

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 11, 2015, Pages 4198-4207

  Yuan, Huiping ^a   Yu, Chenglong ^c,d   Li, Xinghui ^a,b   Sun, Liang ^a   Zhu, Xiaoquan ^a   Zhao, Chengxiao ^a   Zhang, Zheng ^a   Yang, Ze ^a,b  

^a NINGXIA MEDICAL UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

^c SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^d FLINDERS UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

URIC ACID;

ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; DOSE RESPONSE; HIGH RISK PATIENT; HUMAN; LINEAR SYSTEM; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; REFERENCE VALUE; RISK ASSESSMENT; SYSTEMATIC REVIEW; URIC ACID BLOOD LEVEL; ADOLESCENT; ADULT; AGED; CHILD; FEMALE; MALE; META ANALYSIS; MIDDLE AGED; RISK FACTOR; URINE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; URIC ACID; YOUNG ADULT;

EID: 84958629808     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2527     Document Type: Article

References (40)

1. Balkau B, Valensi P, Eschwège E, Slama G.Areview of the metabolic syndrome. Diabetes Metab. 2007;33:405-413.
2. Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009;32: 1737-1742.
3. Lv Q, Meng XF, He FF, et al. High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies. PLoS One. 2013;8:e56864.
4. DeBosch BJ, Kluth O, Fujiwara H, Schurmann A, Moley K. Earlyonset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642.
5. Facchini F, Chen YD, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA. 1991; 266:3008-3011.
6. Carbone F, Montecucco F,MachF, Pontremoli R, Viazzi F. The liver and the kidney: Two critical organs influencing the atherothrombotic risk in metabolic syndrome. Thromb Haemost. 2013;110: 940-958.
7. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: A feature of the metabolic syndrome. Diabetes. 2001;50: 1844-1850.
8. Ryu S, Chang Y, Kim SG, Cho J, Guallar E. Serum uric acid levels predict incident nonalcoholic fatty liver disease in healthy Korean men. Metabolism. 2011;60:860-866.
9. Sirota JC,McFannK, Targher G, Johnson RJ, ChoncholM,Jalal DI. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013;62:392-399.
10. Cardoso AS, Gonzaga NC, Medeiros CC, Carvalho DF. Association of uric acid levels with components of metabolic syndrome and non-alcoholic fatty liver disease in overweight or obese children and adolescents. J Pediatr (Rio J). 2013;89:412-418.
11. Baba T, Amasaki Y, Soda M, et al. Fatty liver and uric acid levels predict incident coronary heart disease but not stroke among atomic bomb survivors in Nagasaki. Hypertens Res. 2007;30:823-829.
12. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology:Aproposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008-2012.
13. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int J Surg. 2010;8:336-341.
14. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2011. Available from: http://www.ohrica/programs/clinical-epidemiology/oxfordasp.
15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
16. RyuS, Song J, Choi BY, et al. Incidence and risk factors for metabolic syndrome in Korean male workers, ages 30 to 39. Ann Epidemiol. 2007;17:245-252.
17. Sui X, Church TS, Meriwether RA, Lobelo F, Blair SN. Uric acid and the development of metabolic syndrome in women and men. Metabolism. 2008;57:845-852.
18. Yang T, Chu CH, Bai CH, et al. Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study. Atherosclerosis. 2012; 220:525-531.
19. Wang JY, Chen YL, Hsu CH, Tang SH, Wu CZ, Pei D. Predictive value of serum uric acid levels for the diagnosis of metabolic syndrome in adolescents. J Pediatr. 2012;161:753-756 e752.
20. Zhang Q, Zhang C, Song X, et al. A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population. BMC Public Health. 2012; 12:419.
21. Zhang ML, Gao YX, Wang X, Chang H, Huang GW. Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults. J Clin Biochem Nutr. 2013;52: 38-42.
22. Ferrara LA, Wang H, Umans JG, et al. Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity. Nutr Metab Cardiovasc Dis. 2014;24:1360-1364.
23. Nagahama K, Inoue T, Kohagura K, Ishihara A, Kinjo K, Ohya Y. Hyperuricemia predicts future metabolic syndrome: A 4-year follow-up study of a large screened cohort in Okinawa, Japan. Hypertens Res. 2014;37:232-238.
24. Lee JK, Ryoo JH, Choi JM, Park SK. Serum uric acid level and the incidence of metabolic syndrome in middle-aged Korean men: A 5-year follow-up study. J Prev Med Public Health. 2014;47:317-326.
25. Oda E. Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population. Heart Vessels. 2014;29:496-503.
26. Babio N, Martinez-Gonzalez MA, Estruch R, et al. Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study. Nutr Metab Cardiovasc Dis. 2015;25(2):173-180.
27. Wu SJ, Zhu GQ, Ye BZ, et al. Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults:Alarge population-based study. Medicine (Baltimore). 2015; 94:e802.
28. Xu C, Yu C, Xu L, Miao M, Li Y. High serum uric acid increases the risk for nonalcoholic fatty liver disease:Aprospective observational study. PLoS One. 2010;5:e11578.
29. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992;135:1301-1309.
30. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455-463.
31. Alkerwi A, Boutsen M, Vaillant M, et al. Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies. Atherosclerosis. 2009;204:624-635.
32. Sun K, Liu J, Ning G. Active smoking and risk of metabolic syndrome: A meta-analysis of prospective studies. PLoS One. 2012;7: e47791.
33. He D, Xi B, Xue J, Huai P, Zhang M, Li J. Association between leisure time physical activity and metabolic syndrome: A meta-analysis of prospective cohort studies. Endocrine. 2014;46:231-240.
34. Liberopoulos EN, Miltiadous GA, Elisaf MS. Alcohol intake, serum uric acid concentrations, and risk of gout. Lancet. 2004;364:246-247; author reply 247.
35. Billiet L, Doaty S, Katz JD, VelasquezMT.Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol. 2014; 2014:852954.
36. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidasemediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007;293:C584-C596.
37. Khosla UM, Zharikov S, Finch JL, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67:1739-1742.
38. Suzuki I, Yamauchi T, Onuma M, Nozaki S. Allopurinol, an inhibitor of uric acid synthesis-Can it be used for the treatment of metabolic syndrome and related disorders? Drugs Today (Barc). 2009; 45:363-378.
39. Nakagawa T, Hu H, Zharikov S, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006;290:F625-F631.
40. García-Ruiz I, Rodríguez-Juan C, Díaz-Sanjuan T , et al. Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice. Hepatology. 2006;44:581-591.