-
1
-
-
0025997018
-
Medicinal chemistry in the golgen age of biology: Lessons from steroid and peptide research
-
R. Hirschmann, Medicinal chemistry in the golgen age of biology: Lessons from steroid and peptide research. Angew. Chem. Int. Ed. Engl. 1991, 30, 1278-1301.
-
(1991)
Angew. Chem. Int. Ed. Engl.
, vol.30
, pp. 1278-1301
-
-
Hirschmann, R.1
-
2
-
-
0027261491
-
Excursion in drug discovery
-
A. A. Patchett, Excursion in drug discovery. J. Med. Chem. 1993, 36, 205.1-2058.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 2051-2058
-
-
Patchett, A.A.1
-
3
-
-
0028243847
-
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
-
M. A. Gallop, R. W. Barrett, W. J. Dower, S. P. A. Fodor, E. M. Gordon, Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J. Med. Chem. 1994, 37, 1233-1251.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1233-1251
-
-
Gallop, M.A.1
Barrett, R.W.2
Dower, W.J.3
Fodor, S.P.A.4
Gordon, E.M.5
-
4
-
-
0028318863
-
Applications of combinational technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions
-
E. M. Gordon, R. W. Barrett, W. J. Dower, S. P. A. Fodor, M. A. Gallop, Applications of combinational technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. J. Med. Chem. 1994, 37, 1385-1401.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1385-1401
-
-
Gordon, E.M.1
Barrett, R.W.2
Dower, W.J.3
Fodor, S.P.A.4
Gallop, M.A.5
-
5
-
-
77956847917
-
Recent advances in the generation of molecular diversity
-
W. H. Moos, G. D. Green, M. R. Pavia, Recent advances in the generation of molecular diversity. Annu. Rep. Med. Chem. 1993, 28, 315-324.
-
(1993)
Annu. Rep. Med. Chem.
, vol.28
, pp. 315-324
-
-
Moos, W.H.1
Green, G.D.2
Pavia, M.R.3
-
6
-
-
0027406752
-
Novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides
-
and references cited therein
-
S. A. Kates, N. A. Sole, C. R. Johnson, D. Hudson, G. Barany, F. A. Albericio, Novel, convenient, three-dimensional orthogonal strategy for solid-phase synthesis of cyclic peptides. Tetrahedron Lett. 1993, 34, 1549-1552 and references cited therein.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 1549-1552
-
-
Kates, S.A.1
Sole, N.A.2
Johnson, C.R.3
Hudson, D.4
Barany, G.5
Albericio, F.A.6
-
7
-
-
0026521405
-
Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis
-
R. N. Zuckermann, J. M. Kerr, M. A. Siani, S. C. Banville, D. V. Santi, Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis. Proc. Natl. Acad. Sci. USA 1992, 89, 4505-4509.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 4505-4509
-
-
Zuckermann, R.N.1
Kerr, J.M.2
Siani, M.A.3
Banville, S.C.4
Santi, D.V.5
-
8
-
-
0027452780
-
Identification of antibody mimotopes containing non-natural amino acids by recombinant and synthetic peptide library affinity selection methods
-
J. M. Kerr, S. C. Banville, R. N. Zuckermann, Identification of antibody mimotopes containing non-natural amino acids by recombinant and synthetic peptide library affinity selection methods. Bioorg. Med. Chem. Lett. 1993, 3, 463-468.
-
(1993)
Bioorg. Med. Chem. Lett.
, vol.3
, pp. 463-468
-
-
Kerr, J.M.1
Banville, S.C.2
Zuckermann, R.N.3
-
9
-
-
0026419319
-
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
-
R. A. Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature (London) 1991, 354, 84-86.
-
(1991)
Nature (London)
, vol.354
, pp. 84-86
-
-
Houghten, R.A.1
Pinilla, C.2
Blondelle, S.E.3
Appel, J.R.4
Dooley, C.T.5
Cuervo, J.H.6
-
11
-
-
0000772738
-
Encoded combinatorial peptide libraries containing non-natural amino acids
-
J. M. Kerr, S. C. Banville, R. N. Zuckermann, Encoded combinatorial peptide libraries containing non-natural amino acids. J. Am. Chem. Soc. 1993, 115, 2529-2531.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 2529-2531
-
-
Kerr, J.M.1
Banville, S.C.2
Zuckermann, R.N.3
-
12
-
-
0027375520
-
Generation and screening of an oligonucleotide-encoded synthetic peptide library
-
M. C. Needles, D. G. Jones, E. H. Tate, G. L. Heinkel, L. M. Kochersperger, W. J. Barrett, M. A. Gallop, Generation and screening of an oligonucleotide-encoded synthetic peptide library. Proc. Natl. Acad. Sci. USA 1993, 90, 10700-10704.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10700-10704
-
-
Needles, M.C.1
Jones, D.G.2
Tate, E.H.3
Heinkel, G.L.4
Kochersperger, L.M.5
Barrett, W.J.6
Gallop, M.A.7
-
13
-
-
0027362628
-
Complex synthetic chemical libraries indexed with molecular tags
-
M. H. J. Ohlmeyer, R. N. Swanson, L. W. Dillard, J. C. Reader, G. Asouline, R. Kobayashi, M. Wigler, W. C. Still, Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. USA 1993, 90, 10922-10926.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10922-10926
-
-
Ohlmeyer, M.H.J.1
Swanson, R.N.2
Dillard, L.W.3
Reader, J.C.4
Asouline, G.5
Kobayashi, R.6
Wigler, M.7
Still, W.C.8
-
14
-
-
0026108692
-
Light-directed, spatially addressable parallel chemical synthesis
-
S. P. A. Fodor, J. L. Read, M. C. Pirrung, L. Stryer, A. T. Lu, D. Solas, Light-directed, spatially addressable parallel chemical synthesis. Science 1991, 251, 767-773.
-
(1991)
Science
, vol.251
, pp. 767-773
-
-
Fodor, S.P.A.1
Read, J.L.2
Pirrung, M.C.3
Stryer, L.4
Lu, A.T.5
Solas, D.6
-
15
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
K. Lam, S. Salmon, E. Hersh, V. Hruby, W. Kazmiersky, R. A. Knapp, A new type of synthetic peptide library for identifying ligand-binding activity. Nature (London) 1991, 354, 82-84.
-
(1991)
Nature (London)
, vol.354
, pp. 82-84
-
-
Lam, K.1
Salmon, S.2
Hersh, E.3
Hruby, V.4
Kazmiersky, W.5
Knapp, R.A.6
-
16
-
-
33751143402
-
Multiple peptide synthesis methods and their applications
-
G. Jung, A. G. Beck-Sickinger, Multiple peptide synthesis methods and their applications. Angew. Chem. Int. Ed. Engl. 1992, 31, 367-486.
-
(1992)
Angew. Chem. Int. Ed. Engl.
, vol.31
, pp. 367-486
-
-
Jung, G.1
Beck-Sickinger, A.G.2
-
17
-
-
0002340017
-
Obstacles to drug developement from peptide leads
-
(Eds.: C. R. Clark, W. H. Moos) Elllis Horwood Limited: Chichester, England
-
J. J. Plattner, D. W. Norbeck, Obstacles to drug developement from peptide leads in Drug Discovery Technologies (Eds.: C. R. Clark, W. H. Moos) Elllis Horwood Limited: Chichester, England, 1990, pp. 92-126.
-
(1990)
Drug Discovery Technologies
, pp. 92-126
-
-
Plattner, J.J.1
Norbeck, D.W.2
-
18
-
-
0027185750
-
The chemical synthesis of peptidomimetic libraries
-
R. N. Zuckermann, The chemical synthesis of peptidomimetic libraries. Curr. Opin. Struct. Biol. 1993, 3, 580-584.
-
(1993)
Curr. Opin. Struct. Biol.
, vol.3
, pp. 580-584
-
-
Zuckermann, R.N.1
-
19
-
-
0026726041
-
Peptoids: A modular approach to drug discovery
-
R. J. Simon, R. S. Kania, R. N. Zuckermann, V. D. Huebner, D. A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C. K. Marlowe, D. C. Spellmeyer, R. Tan, A. D. Frankel, D. V. Santi, F. E. Cohen, P. A. Bartlett, Peptoids: A modular approach to drug discovery. Proc. Natl. Acad. Sci. USA 1992, 89, 9367-9371.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 9367-9371
-
-
Simon, R.J.1
Kania, R.S.2
Zuckermann, R.N.3
Huebner, V.D.4
Jewell, D.A.5
Banville, S.6
Ng, S.7
Wang, L.8
Rosenberg, S.9
Marlowe, C.K.10
Spellmeyer, D.C.11
Tan, R.12
Frankel, A.D.13
Santi, D.V.14
Cohen, F.E.15
Bartlett, P.A.16
-
20
-
-
0029059507
-
Comparison of the proteolytic susceptibilities of homologous L-amino acid, D-amino acid and N-substituted glycine peptide and peptoid oligomers
-
S. M. Miller, R. J. Simon, S. Ng, R. N. Zuckermann, W. H. Moos, Comparison of the proteolytic susceptibilities of homologous L-amino acid, D-amino acid and N-substituted glycine peptide and peptoid oligomers. Drug Dev. Res. 1995, 35, 20-32.
-
(1995)
Drug Dev. Res.
, vol.35
, pp. 20-32
-
-
Miller, S.M.1
Simon, R.J.2
Ng, S.3
Zuckermann, R.N.4
Moos, W.H.5
-
21
-
-
84958287130
-
-
unpublished results
-
D. C. Spellmeyer, unpublished results.
-
-
-
Spellmeyer, D.C.1
-
22
-
-
0000221380
-
General parameterized SCF model for free energies of solvation in aqueous solution
-
9901 (E)
-
C. J. Cramer, D. G. Truhlar, General parameterized SCF model for free energies of solvation in aqueous solution. J. Am. Chem. Soc. 1991, 113, 8305, 9901 (E).
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 8305
-
-
Cramer, C.J.1
Truhlar, D.G.2
-
23
-
-
0027013007
-
AM1-SM2 and PM3-SM3 Parameterized solvation models for free energies in aqueous solution
-
C. J. Cramer, D. G. Truhlar, AM1-SM2 and PM3-SM3 Parameterized solvation models for free energies in aqueous solution. J. Computer Aided Mol. Design 1992, 6, 629-666.
-
(1992)
J. Computer Aided Mol. Design
, vol.6
, pp. 629-666
-
-
Cramer, C.J.1
Truhlar, D.G.2
-
25
-
-
0000908874
-
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
-
R. N. Zuckermann, J. M. Kerr, S. B. H. Kent, W. H. Moos, Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis. J. Am. Chem. Soc. 1992, 114, 10646-10647.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 10646-10647
-
-
Zuckermann, R.N.1
Kerr, J.M.2
Kent, S.B.H.3
Moos, W.H.4
-
26
-
-
0007965875
-
Synthesis of (N-substituted) glycine polymers of defined sequence and length
-
R. N. Zuckermann, D. A. Goff, Synthesis of (N-substituted) glycine polymers of defined sequence and length. ACS Polymer Preprint 1994, 35, 975-976.
-
(1994)
ACS Polymer Preprint
, vol.35
, pp. 975-976
-
-
Zuckermann, R.N.1
Goff, D.A.2
-
27
-
-
0026619715
-
Design, construction and application of a fully automated equimolar peptide mixture synthesizer
-
R. N. Zuckermann, J. M. Kerr, M. A. Siani, S. C. Banville, Design, construction and application of a fully automated equimolar peptide mixture synthesizer. Int. J. Pept. Protein Res. 1992, 40, 497-506.
-
(1992)
Int. J. Pept. Protein Res.
, vol.40
, pp. 497-506
-
-
Zuckermann, R.N.1
Kerr, J.M.2
Siani, M.A.3
Banville, S.C.4
-
28
-
-
12644294161
-
Control of the zymate robot with an external computer: Construction of a multiple peptide synthesizer
-
R. N. Zuckermann, M. A. Siani, S. C. Banville, Control of the zymate robot with an external computer: construction of a multiple peptide synthesizer. Lab. Robotics Automation 1992, 4, 183-192.
-
(1992)
Lab. Robotics Automation
, vol.4
, pp. 183-192
-
-
Zuckermann, R.N.1
Siani, M.A.2
Banville, S.C.3
-
29
-
-
0026867323
-
Automated peptide-resin deprotection/cleavage by a robotic workstation
-
R. N. Zuckermann, S. C. Banville, Automated peptide-resin deprotection/cleavage by a robotic workstation Pept. Res. 1992, 5, 169-174.
-
(1992)
Pept. Res.
, vol.5
, pp. 169-174
-
-
Zuckermann, R.N.1
Banville, S.C.2
-
30
-
-
84958231932
-
-
Available Chemicals Directory 93.1, San Leandro, CA
-
Available Chemicals Directory 93.1, Molecular Design Limited, San Leandro, CA, 1993.
-
(1993)
Molecular Design Limited
-
-
-
31
-
-
0028953765
-
Measuring Diversity: Experimental design of combinatorial libraries for drug discovery
-
E. J. Martin, J. M. Blaney, M. A. Siani, D. C. Spellmeyer, A. K. Wong, W. H. Moos, Measuring Diversity: experimental design of combinatorial libraries for drug discovery. J. Med. Chem. 1995, 38, 1431-1436.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 1431-1436
-
-
Martin, E.J.1
Blaney, J.M.2
Siani, M.A.3
Spellmeyer, D.C.4
Wong, A.K.5
Moos, W.H.6
-
33
-
-
0026485548
-
A method for evaluating the effects of ligands upon G-protein-coupled receptors using a recombinant melanophore-based bioassay
-
M. N. Potenza, G. F. Graminski, M. R. Lerner, A method for evaluating the effects of ligands upon G-protein-coupled receptors using a recombinant melanophore-based bioassay. Anal. Biochem. 1992, 206, 315-322.
-
(1992)
Anal. Biochem.
, vol.206
, pp. 315-322
-
-
Potenza, M.N.1
Graminski, G.F.2
Lerner, M.R.3
-
34
-
-
0026669569
-
Sequence alignment of the G-protein coupled receptor superfamily
-
W. C. Probst, L. A. Snyder, D. I. Schuster, J. Brosius, S. C. Sealfon, Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol. 1992, 11, 1-20.
-
(1992)
DNA Cell Biol.
, vol.11
, pp. 1-20
-
-
Probst, W.C.1
Snyder, L.A.2
Schuster, D.I.3
Brosius, J.4
Sealfon, S.C.5
-
35
-
-
0027934780
-
Discovery of nanomolar ligands for 7-transmembrane G-protein coupled receptors from a diverse (N-substituted)glyrine peptoid library
-
R. N. Zuckermann, E. J. Martin, D. C. Spellmeyer, G. B Stauber, K. R. Shoemaker, J. M. Kerr, G. M. Figliozzi, D. A. Goff, M. A. Siani, R. J. Simon, S. C. Banville, E. G. Brown, L. Wang, L. S. Richter, W. H. Moos, Discovery of nanomolar ligands for 7-transmembrane G-protein coupled receptors from a diverse (N-substituted)glyrine peptoid library. J. Med. Chem. 1994, 37, 2678-2685.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2678-2685
-
-
Zuckermann, R.N.1
Martin, E.J.2
Spellmeyer, D.C.3
B Stauber, G.4
Shoemaker, K.R.5
Kerr, J.M.6
Figliozzi, G.M.7
Goff, D.A.8
Siani, M.A.9
Simon, R.J.10
Banville, S.C.11
Brown, E.G.12
Wang, L.13
Richter, L.S.14
Moos, W.H.15
-
36
-
-
0019479001
-
Identical antagonist selectivity of central and peripheral alphal-adrenoceptors
-
P. B. M. W. M. Timmermans, F. K. Ali, H. Y. Kwa, A. M. C. Schoop, F. P. Slothorst-Grisdijk, P. A. v. Zwieten, Identical antagonist selectivity of central and peripheral alphal-adrenoceptors. Mol. Pharmacol. 1981, 20, 295-301.
-
(1981)
Mol. Pharmacol.
, vol.20
, pp. 295-301
-
-
Timmermans, P.B.M.W.M.1
Ali, F.K.2
Kwa, H.Y.3
Schoop, A.M.C.4
Slothorst-Grisdijk, F.P.5
Zwieten, P.A.V.6
-
37
-
-
0019949464
-
Spectrum of the mu-, delta-, and kappa-binding sites in homogenates of rat brain
-
M. G. C. Gillan, H. W. Kosterlitz, Spectrum of the mu-, delta-, and kappa-binding sites in homogenates of rat brain. Br. J. Pharm. 1982, 77, 461-469.
-
(1982)
Br. J. Pharm.
, vol.77
, pp. 461-469
-
-
Gillan, M.G.C.1
Kosterlitz, H.W.2
-
38
-
-
84958287131
-
-
see refs. 3-5 and references cited therein
-
see refs. 3-5 and references cited therein.
-
-
-
-
39
-
-
45949123116
-
Solid-phase synthesis of protected peptide fragments using a trialkoxy-di-phenyl-methylester resin
-
H. Rink, Solid-phase synthesis of protected peptide fragments using a trialkoxy-di-phenyl-methylester resin. Tetrahedron Lett. 1987, 28, 3787-3790.
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 3787-3790
-
-
Rink, H.1
-
40
-
-
0029896177
-
Synthesis of N-Substituted glycine peptoid libraries
-
G. M. Figliozzi, R. Goldsmith, S. C. Ng, S. C. Banville, R. N. Zuckermann, Synthesis of N-Substituted glycine peptoid libraries. Methods in Enzymology. 1996,267, 437-447.
-
(1996)
Methods in Enzymology
, vol.267
, pp. 437-447
-
-
Figliozzi, G.M.1
Goldsmith, R.2
Ng, S.C.3
Banville, S.C.4
Zuckermann, R.N.5
|