Planarians: An in vivo model for regenerative medicine

International Journal of Stem Cells

Volumn 8, Issue 2, 2015, Pages 128-133

  Karami, Ali ^a   Tebyanian, Hamid ^a   Goodarzi, Vahabodin ^a   Shiri, Sajad ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Blastema; Differentiation; Neoblast; Regenerative medicine; Schmidtea mediterranea

Indexed keywords

EID: 84958205987     PISSN: 20053606     EISSN: 20055447     Source Type: Journal    
DOI: 10.15283/ijsc.2015.8.2.128     Document Type: Article

References (34)

1. Elliott, SA, and Sánchez Alvarado, A (2013). The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol. 2, 301-326.
2. Sánchez Alvarado, A (2006). Planarian regeneration: its end is its beginning. Cell. 124, 241-245.
3. Randolph, H (1892). The regeneration of the tail in lumbriculus. J Morphol. 7, 317-344.
4. Reddien, PW, and Sánchez Alvarado, A (2004). Fundamentals of planarian regeneration. Annu Rev Cell Dev Biol. 20, 725-757.
5. Onal, P, Grün, D, Adamidi, C, Rybak, A, Solana, J, Mastrobuoni, G, Wang, Y, Rahn, HP, Chen, W, Kempa, S, Ziebold, U, and Rajewsky, N (2012). Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J. 31, 2755-2769.
6. van Wolfswinkel, JC, Wagner, DE, and Reddien, PW (2014). Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment. Cell Stem Cell. 15, 326-339.
7. Sánchez Alvarado, A, and Newmark, PA (1998). The use of planarians to dissect the molecular basis of metazoan regeneration. Wound Repair Regen. 6, 413-420.
8. Umesono, Y, Watanabe, K, and Agata, K (1997). A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain. Dev Growth Differ. 39, 723-727.
9. Sánchez Alvarado, A, Newmark, PA, Robb, SM, and Juste, R (2002). The Schmidtea mediterranea database as a molecular resource for studying platyhelminthes, stem cells and regeneration. Development. 129, 5659-5665.
10. Sánchez Alvarado, A, and Tsonis, PA (2006). Bridging the regeneration gap: genetic insights from diverse animal models. Nat Rev Genet. 7, 873-884.
11. Eisenhoffer, GT, Kang, H, and Sánchez Alvarado, A (2008). Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell. 3, 327-339.
12. Wagner, DE, Wang, IE, and Reddien, PW (2011). Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science. 332, 811-816.
13. Reddien, PW (2013). Specialized progenitors and regeneration. Development. 140, 951-957.
14. Scimone, ML, Kravarik, KM, Lapan, SW, and Reddien, PW (2014). Neoblast specialization in regeneration of the planarian Schmidtea mediterranea. Stem Cell Reports. 3, 339-352.
15. Morgan, TH (1901). Regeneration. New York: The Macmillan Company, pp. 316.
16. Newmark, PA, and Sánchez Alvarado, A (2002). Not your father's planarian: a classic model enters the era of functional genomics. Nat Rev Genet. 3, 210-219.
17. Reisinger, E, and Kelbetz, S (1964). Fine structure and discharge mechanism of rhabdites. Z Wiss Mikrosk. 65, 472-508.
18. Almuedo-Castillo, M, Sureda-Gómez, M, and Adell, T (2012). Wnt signaling in planarians: new answers to old questions. Int J Dev Biol. 56, 53-65.
19. Oviedo, NJ, and Beane, WS (2009). Regeneration: The origin of cancer or a possible cure?. Semin Cell Dev Biol. 20, 557-564.
20. Lee, SM, Kok, KH, Jaume, M, Cheung, TK, Yip, TF, Lai, JC, Guan, Y, Webster, RG, Jin, DY, and Peiris, JS (2014). Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection. Proc Natl Acad Sci U S A. 111, 3793-3798.
21. Witchley, JN, Mayer, M, Wagner, DE, Owen, JH, and Reddien, PW (2013). Muscle cells provide instructions for planarian regeneration. Cell Rep. 4, 633-641.
22. Umesono, Y, Tasaki, J, Nishimura, Y, Hrouda, M, Kawaguchi, E, Yazawa, S, Nishimura, O, Hosoda, K, Inoue, T, and Agata, K (2013). The molecular logic for planarian regeneration along the anterior-posterior axis. Nature. 500, 73-76.
23. Yazawa, S, Umesono, Y, Hayashi, T, Tarui, H, and Agata, K (2009). Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling. Proc Natl Acad Sci U S A. 106, 22329-22334.
24. Reuter, H, März, M, Vogg, MC, Eccles, D, Grífol-Boldú, L, Wehner, D, Owlarn, S, Adell, T, Weidinger, G, and Bartscherer, K (2015). B-catenin-dependent control of positional information along the AP body axis in planarians involves a teashirt family member. Cell Rep. 10, 253-265.
25. Hayashi, T, Motoishi, M, Yazawa, S, Itomi, K, Tanegashima, C, Nishimura, O, Agata, K, and Tarui, H (2011). A LIM-homeobox gene is required for differentiation of Wnt-expressing cells at the posterior end of the planarian body. Development. 138, 3679-3688.
26. Gilbert, SF (2013). Developmental biology. Sunderland, Mass, USA: Sinauer Associates Inc.
27. Cebrià, F, Kobayashi, C, Umesono, Y, Nakazawa, M, Mineta, K, Ikeo, K, Gojobori, T, Itoh, M, Taira, M, Sánchez Alvarado, A, and Agata, K (2002). FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature. 419, 620-624.
28. Tasaki, J, Shibata, N, Nishimura, O, Itomi, K, Tabata, Y, Son, F, Suzuki, N, Araki, R, Abe, M, Agata, K, and Umesono, Y (2011). ERK signaling controls blastema cell differentiation during planarian regeneration. Development. 138, 2417-2427.
29. Gaviño, MA, and Reddien, PW (2011). A Bmp/Admp regulatory circuit controls maintenance and regeneration of dorsal-ventral polarity in planarians. Curr Biol. 21, 294-299.
30. Molina, MD, Neto, A, Maeso, I, Gómez-Skarmeta, JL, Saló, E, and Cebrià, F (2011). Noggin and noggin-like genes control dorsoventral axis regeneration in planarians. Curr Biol. 21, 300-305.
31. Reddien, PW (2011). Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends Genet. 27, 277-285.
32. Abnave, P, Mottola, G, Gimenez, G, Boucherit, N, Trouplin, V, Torre, C, Conti, F, Ben Amara, A, Lepolard, C, Djian, B, Hamaoui, D, Mettouchi, A, Kumar, A, Pagnotta, S, Bonatti, S, Lepidi, H, Salvetti, A, Abi-Rached, L, Lemichez, E, Mege, JL, and Ghigo, E (2014). Screening in planarians identifies MORN2 as a key component in LC3-associated phagocytosis and resistance to bacterial infection. Cell Host Microbe. 16, 338-350.
33. Prokai, D, Nguyen, T, Kamrowski, K, Chandra, A, Talamantes, T, Baxter, LR, and Prokai, L (2013). An exploratory evaluation of tyrosine hydroxylase inhibition in planaria as a model for parkinsonism. Int J Mol Sci. 14, 23289-23296.
34. Agata, K, Tasaki, J, Nakajima, E, and Umesono, Y (2014). Recent identification of an ERK signal gradient governing planarian regeneration. Zoology (Jena). 117, 161-162.