Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs

Oncotarget

Volumn 7, Issue 5, 2016, Pages 5470-5482

  Zaynagetdinov, Rinat ^a   Sherrill, Taylor P ^a   Gleaves, Linda A ^a   Hunt, Pierre ^a   Han, Wei ^a   McLoed, Allyson G ^a   Saxon, Jamie A ^a   Tanjore, Harikrishna ^a   Gulleman, Peter M ^a   Young, Lisa R ^a   Blackwell, Timothy S ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

COPD; Lung cancer; Macrophage; NF B; Tregs

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; URETHAN; I KAPPA B KINASE; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA;

AIRWAY REMODELING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; LUNG ADENOMA; LUNG ALVEOLUS MACROPHAGE; LUNG CANCER; LUNG CARCINOGENESIS; LUNG EMPHYSEMA; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MOUSE; MOUSE MODEL; NONHUMAN; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT INFLAMMATION; ANIMAL; CELL CULTURE; EPITHELIUM; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; EPITHELIUM; FEMALE; FLOW CYTOMETRY; HUMANS; I-KAPPA B KINASE; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; INTERLEUKIN-10; LUNG; LUNG NEOPLASMS; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, TRANSGENIC; NF-KAPPA B; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84958087374     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6562     Document Type: Article

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