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Volumn 7, Issue 5, 2016, Pages 6266-6280

Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer

Author keywords

Gastric cancer; MELK; Metastasis; PDX; Prognosis

Indexed keywords

MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE; MESSENGER RNA; OTSSP 167; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; LEUCINE ZIPPER PROTEIN;

EID: 84958063199     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6673     Document Type: Article
Times cited : (46)

References (35)
  • 2
    • 84938995003 scopus 로고    scopus 로고
    • Comparison of Gastric Cancer Survival Between Caucasian and Asian Patients Treated in the United States: Results from the Surveillance Epidemiology and End Results (SEER) Database
    • Wang J, Sun Y, Bertagnolli MM. Comparison of Gastric Cancer Survival Between Caucasian and Asian Patients Treated in the United States: Results from the Surveillance Epidemiology and End Results (SEER) Database. Ann Surg Oncol. 2015.
    • (2015) Ann Surg Oncol
    • Wang, J.1    Sun, Y.2    Bertagnolli, M.M.3
  • 3
    • 84880626824 scopus 로고    scopus 로고
    • Metastatic gastric cancer treatment: a little slow but worthy progress
    • Kanat O, O'Neil BH. Metastatic gastric cancer treatment: a little slow but worthy progress. Med Oncol. 2013; 30:464.
    • (2013) Med Oncol , vol.30 , pp. 464
    • Kanat, O.1    O'Neil, B.H.2
  • 4
    • 0030878634 scopus 로고    scopus 로고
    • Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells
    • Gil M, Yang Y, Lee Y, Choi I, Ha H. Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. Gene. 1997; 195:295-301.
    • (1997) Gene , vol.195 , pp. 295-301
    • Gil, M.1    Yang, Y.2    Lee, Y.3    Choi, I.4    Ha, H.5
  • 5
    • 0030898486 scopus 로고    scopus 로고
    • New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo
    • Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL. New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev. 1997; 47:148-156.
    • (1997) Mol Reprod Dev , vol.47 , pp. 148-156
    • Heyer, B.S.1    Warsowe, J.2    Solter, D.3    Knowles, B.B.4    Ackerman, S.L.5
  • 6
    • 0037081166 scopus 로고    scopus 로고
    • Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family
    • Blot J, Chartrain I, Roghi C, Philippe M, Tassan JP. Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family. Dev Biol. 2002; 241:327-338.
    • (2002) Dev Biol , vol.241 , pp. 327-338
    • Blot, J.1    Chartrain, I.2    Roghi, C.3    Philippe, M.4    Tassan, J.P.5
  • 7
    • 0032792305 scopus 로고    scopus 로고
    • Expression of Melk, a new protein kinase, during early mouse development
    • Heyer BS, Kochanowski H, Solter D. Expression of Melk, a new protein kinase, during early mouse development. Dev Dyn. 1999; 215:344-351.
    • (1999) Dev Dyn , vol.215 , pp. 344-351
    • Heyer, B.S.1    Kochanowski, H.2    Solter, D.3
  • 8
    • 34248191375 scopus 로고    scopus 로고
    • Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family
    • Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T. Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. Breast Cancer Res. 2007; 9:R17.
    • (2007) Breast Cancer Res , vol.9
    • Lin, M.L.1    Park, J.H.2    Nishidate, T.3    Nakamura, Y.4    Katagiri, T.5
  • 9
    • 0037206945 scopus 로고    scopus 로고
    • Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation
    • Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. Oncogene. 2002; 21:7630-7641.
    • (2002) Oncogene , vol.21 , pp. 7630-7641
    • Davezac, N.1    Baldin, V.2    Blot, J.3    Ducommun, B.4    Tassan, J.P.5
  • 10
    • 1542275529 scopus 로고    scopus 로고
    • Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1
    • Vulsteke V, Beullens M, Boudrez A, Keppens S, Van Eynde A, Rider MH, Stalmans W, Bollen M. Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem. 2004; 279:8642-8647.
    • (2004) J Biol Chem , vol.279 , pp. 8642-8647
    • Vulsteke, V.1    Beullens, M.2    Boudrez, A.3    Keppens, S.4    Van Eynde, A.5    Rider, M.H.6    Stalmans, W.7    Bollen, M.8
  • 12
    • 84900019839 scopus 로고    scopus 로고
    • Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
    • Du T, Qu Y, Li J, Li H, Su L, Zhou Q, Yan M, Li C, Zhu Z, Liu B. Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway. Mol Cancer. 2014; 13:100.
    • (2014) Mol Cancer , vol.13 , pp. 100
    • Du, T.1    Qu, Y.2    Li, J.3    Li, H.4    Su, L.5    Zhou, Q.6    Yan, M.7    Li, C.8    Zhu, Z.9    Liu, B.10
  • 13
    • 58049199391 scopus 로고    scopus 로고
    • Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation
    • Jung H, Seong HA, Ha H. Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. J Biol Chem. 2008; 283:34541-34553.
    • (2008) J Biol Chem , vol.283 , pp. 34541-34553
    • Jung, H.1    Seong, H.A.2    Ha, H.3
  • 16
    • 80052022586 scopus 로고    scopus 로고
    • Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression
    • Choi S, Ku JL. Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. Biochem Biophys Res Commun. 2011; 412:207-213.
    • (2011) Biochem Biophys Res Commun , vol.412 , pp. 207-213
    • Choi, S.1    Ku, J.L.2
  • 20
    • 78449267044 scopus 로고    scopus 로고
    • Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumorinitiating cells in vivo
    • Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV. Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumorinitiating cells in vivo. Cancer Res. 2010; 70:8863-8873.
    • (2010) Cancer Res , vol.70 , pp. 8863-8873
    • Hebbard, L.W.1    Maurer, J.2    Miller, A.3    Lesperance, J.4    Hassell, J.5    Oshima, R.G.6    Terskikh, A.V.7
  • 21
    • 84876567183 scopus 로고    scopus 로고
    • Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner
    • Gu C, Banasavadi-Siddegowda YK, Joshi K, Nakamura Y, Kurt H, Gupta S, Nakano I. Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Stem Cells. 2013; 31:870-881.
    • (2013) Stem Cells , vol.31 , pp. 870-881
    • Gu, C.1    Banasavadi-Siddegowda, Y.K.2    Joshi, K.3    Nakamura, Y.4    Kurt, H.5    Gupta, S.6    Nakano, I.7
  • 22
    • 84874680562 scopus 로고    scopus 로고
    • Development of an orally-administrative MELKtargeting inhibitor that suppresses the growth of various types of human cancer
    • Chung S, Suzuki H, Miyamoto T, Takamatsu N, Tatsuguchi A, Ueda K, Kijima K, Nakamura Y, Matsuo Y. Development of an orally-administrative MELKtargeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012; 3:1629-1640. doi: 10.18632/oncotarget.790.
    • (2012) Oncotarget , vol.3 , pp. 1629-1640
    • Chung, S.1    Suzuki, H.2    Miyamoto, T.3    Takamatsu, N.4    Tatsuguchi, A.5    Ueda, K.6    Kijima, K.7    Nakamura, Y.8    Matsuo, Y.9
  • 24
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    • Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene. 2005; 24:7443-7454.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 28
    • 84934342479 scopus 로고    scopus 로고
    • Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model
    • Jiang J, Wang DD, Yang M, Chen D, Pang L, Guo S, Cai J, Wery JP, Li L, Li HQ, Lin PP. Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model. Oncotarget. 2015. doi: 10.18632/oncotarget.3712.
    • (2015) Oncotarget
    • Jiang, J.1    Wang, D.D.2    Yang, M.3    Chen, D.4    Pang, L.5    Guo, S.6    Cai, J.7    Wery, J.P.8    Li, L.9    Li, H.Q.10    Lin, P.P.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.