MR tracking of SPIO-labeled mesenchymal stem cells in rats with liver fibrosis could not monitor the cells accurately

Contrast Media and Molecular Imaging

Volumn 10, Issue 6, 2015, Pages 473-480

  Zhou, Bin ^a,b   Li, Dan ^a,b   Qian, Jiesheng ^a,b   Li, Zhengran ^a,b   Pang, Pengfei ^a,b   Shan, Hong ^a,b,c  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b Medical Research Center of Guangdong Provincial Hospital   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Distribution; Liver injury; Magnetic resonance imaging; Mesenchymal stem cells; Tracking

Indexed keywords

SUPERPARAMAGNETIC IRON OXIDE; CONTRAST MEDIUM; DEXTRAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MAGNETITE NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL LABELING; CELL MONITORING; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; HEART; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER; LIVER FIBROSIS; LIVER INTRALOBULAR PARENCHYMA; LIVER PARENCHYMA; LUNG; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENTERIC VEIN; MONITORING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SPLEEN; SRY GENE; TIME SERIES ANALYSIS; TISSUE DISTRIBUTION; ANIMAL; BONE MARROW CELL; CHEMISTRY; CYTOLOGY; LIVER CIRRHOSIS; MESENCHYMAL STROMA CELL; PATHOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; STAINING;

ANIMALS; BONE MARROW CELLS; CONTRAST MEDIA; DEXTRANS; FEMALE; GREEN FLUORESCENT PROTEINS; LIVER; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MAGNETITE NANOPARTICLES; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; STAINING AND LABELING;

EID: 84957958308     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.1650     Document Type: Article

References (35)

1. Friedman SL. Liver fibrosis - from bench to bedside. J Hepatol 2003; 38(Suppl 1): S38-53.
2. Gines P, Cardenas A, Arroyo V, Rodes J. Management of cirrhosis and ascites. N Engl J Med 2004; 350(16): 1646-1654.
3. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, Sato T, Miyanishi K, Takayama T, Takahashi M, Takimoto R, Iyama S, Matsunaga T, Ohtani S, Matsuura A, Hamada H, Niitsu Y. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood 2005; 106(2): 756-763.
4. Kuo TK, Hung SP, Chuang CH, Chen CT, Shih YR, Fang SC, Yang VW, Lee OK. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 2008; 134(7): 2111-2121, e2111-2113.
5. Peng L, Xie DY, Lin BL, Liu J, Zhu HP, Xie C, Zheng YB, Gao ZL. Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology 2011; 54(3): 820-828.
6. Abdel Aziz MT, Atta HM, Mahfouz S, Fouad HH, Roshdy NK, Ahmed HH, Rashed LA, Sabry D, Hassouna AA, Hasan NM. Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem 2007; 40(12): 893-899.
7. Zhao DC, Lei JX, Chen R, Yu WH, Zhang XM, Li SN, Xiang P. Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World J Gastroenterol 2005; 11(22): 3431-3440.
8. + mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice. Transplantation 2004; 78(1): 83-88.
9. Taylor A, Wilson KM, Murray P, Fernig DG, Lévy R. Long-term tracking of cells using inorganic nanoparticles as contrast agents: are we there yet? Chem Soc Rev 2012; 41(7): 2707-2717.
10. Golovko DM, Henning T, Bauer JS, Settles M, Frenzel T, Mayerhofer A, Rummeny EJ, Daldrup-Link HE. Accelerated stem cell labeling with ferucarbotran and protamine. Eur Radiol 2010; 20(3): 640-648.
11. Zhou B, Shan H, Li D, Jiang ZB, Qian JS, Zhu KS, Huang MS, Meng XC. MR tracking of magnetically labeled mesenchymal stem cells in rats with liver fibrosis. Magn Reson Imaging 2010; 28(3): 394-399.
12. Ju S, Teng GJ, Lu H, Zhang Y, Zhang A, Chen F, Ni Y. In vivo MR tracking of mesenchymal stem cells in rat liver after intrasplenic transplantation. Radiology 2007; 245(1): 206-215.
13. Qin ZH, Qu JM, Xu JF, Zhang J, Summah H, Sai-Yin HX, Chen CM, Yu L. Intrapleural delivery of mesenchymal stem cells: a novel potential treatment for pleural diseases. Acta Pharmacol Sin 2011; 32(5): 581-590.
14. Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH. Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells 2002; 20(3): 249-258.
15. Barbash IM, Chouraqui P, Baron J, Feinberg MS, Etzion S, Tessone A, Miller L, Guetta E, Zipori D, Kedes LH, Kloner RA, Leor J. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 2003; 108(7): 863-868.
16. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH Jr, Bulte JW. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003; 228(2): 480-487.
17. Zhang B, Shan H, Li D, Li ZR, Zhu KS, Jiang ZB. The inhibitory effect of MSCs expressing TRAIL as a cellular delivery vehicle in combination with cisplatin on hepatocellular carcinoma. Cancer Biol Ther 2012; 13(12): 1175-1184.
18. Arai T, Kofidis T, Bulte JW, de Bruin J, Venook RD, Berry GJ, McConnell MV, Quertermous T, Robbins RC, Yang PC. Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 T. Magn Reson Med 2006; 55(1): 203-209.
19. Tang H, Sha H, Sun H, Wu X, Xie L, Wang P, Xu C, Larsen C, Zhang HL, Gong Y, Mao Y, Chen X, Zhou L, Feng X, Zhu J. Tracking induced pluripotent stem cells-derived neural stem cells in the central nervous system of rats and monkeys. Cell Reprogramming 2013; 15(5): 435-442.
20. Puppi J, Modo M, Dhawan A, Lehec SC, Mitry RR, Hughes RD. Ex vivo magnetic resonance imaging of transplanted hepatocytes in a rat model of acute liver failure. Cell Transpl 2014; 23(3): 329-343.
21. Saraswathy A, Nazeer SS, Jeevan M, Nimi N, Arumugam S, Harikrishnan VS, Varma PR, Jayasree RS. Citrate coated iron oxide nanoparticles with enhanced relaxivity for in vivo magnetic resonance imaging of liver fibrosis. Colloids Surf B Biointerfaces 2014; 117: 216-224.
22. Hua P, Wang YY, Liu LB, Liu JL, Liu JY, Yang YQ, Yang SR. In vivo magnetic resonance imaging tracking of transplanted superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells in rats with myocardial infarction. Mol Med Rep 2015; 11(1): 113-120.
23. Son KR, Chung SY, Kim HC, Kim HS, Choi SH, Lee JM, Moon WK. MRI of magnetically labeled mesenchymal stem cells in hepatic failure model. World J Gastroenterol 2010; 16(44): 5611-5615.
24. Ma N, Cheng H, Lu M, Liu Q, Chen X, Yin G, Zhu H, Zhang L, Meng X, Tang Y, Zhao S. Magnetic resonance imaging with superparamagnetic iron oxide fails to track the long-term fate of mesenchymal stem cells transplanted into heart. Sci Rep 2015; 5(3): 9058/1-9.
25. Chen J, Wang F, Zhang Y, Jin X, Zhang L, Feng Y, Lin X, Yang L. In vivo tracking of superparamagnetic iron oxide nanoparticle labeled chondrocytes in large animal model. Ann Biomed Eng 2012; 40(12): 2568-2578.
26. Yang K, Xiang P, Zhang C, Zou L, Wu X, Gao Y, Kang Z, He K, Liu J, Peng C. Magnetic resonance evaluation of transplanted mesenchymal stem cells after myocardial infarction in swine. Can J Cardiol 2011; 27(6): 818-825.
27. Brazelton TR, Blau HM. Optimizing techniques for tracking transplanted stem cells in vivo. Stem Cells 2005; 23(9): 1251-1265.
28. Cromer Berman SM, Kshitiz, Wang CJ, Orukari I, Levchenko A, Bulte JW, Walczak P. Cell motility of neural stem cells is reduced after SPIO-labeling, which is mitigated after exocytosis. Magn Reson Med 2013; 69(1): 255-262.
29. Roeder E, Henrionnet C, Goebel JC, Gambier N, Beuf O, Grenier D, Chen B, Vuissoz PA, Gillet P, Pinzano A. Dose-response of superparamagnetic iron oxide labeling on mesenchymal stem cells chondrogenic differentiation: a multi-scale in vitro study. PLoS One 2014; 9(5): e98451.
30. Farrell E, Wielopolski P, Pavljasevic P, van Tiel S, Jahr H, Verhaar J, Weinans H, Krestin G, O'Brien FJ, van Osch G, Bernsen M. Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo. Biochem Biophys Res Commun 2008; 369(4): 1076-1081.
31. Muller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA. Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation 2002; 105(14): 1720-1726.
32. Muller-Ehmsen J, Krausgrill B, Burst V, Schenk K, Neisen UC, Fries JW, Fleischmann BK, Hescheler J, Schwinger RH. Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol 2006; 41(5): 876-884.
33. Burst V, Putsch F, Kubacki T, Volker LA, Bartram MP, Muller RU, Gillis M, Kurschat CE, Grundmann F, Muller-Ehmsen J, Benzing T, Teschner S. Survival and distribution of injected haematopoietic stem cells in acute kidney injury. Nephrol Dial Transpl 2013; 28(5): 1131-1139.
34. Zhu X, He B, Zhou X, Ren J. Effects of transplanted bone-marrow-derived mesenchymal stem cells in animal models of acute hepatitis. Cell Tissue Res 2013; 351(3): 477-486.
35. Rustad KC, Gurtner GC. Mesenchymal stem cells home to sites of injury and inflammation. Adv Wound Care 2012; 1(4): 147-152.