Contribution of NRG1 Gene Polymorphisms in Temporal Lobe Epilepsy

Journal of Child Neurology

Volumn 31, Issue 3, 2016, Pages 271-276

  Zhu, Wen Ye ^a,b   Jiang, Pei ^a,b   He, Xin ^a,b   Cao, Ling Juan ^a,b   Zhang, Li Hong ^a,b   Dang, Rui Li ^a,b   Tang, Mi Mi ^a,b   Xue, Ying ^a,b   Li, Huan De ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

GABA; NMDA; NRG1; polymorphism; temporal lobe epilepsy

Indexed keywords

NEU DIFFERENTIATION FACTOR; NRG1 PROTEIN, HUMAN;

ALLELE; ARTICLE; CASE CONTROL STUDY; CHILD; CONTROLLED STUDY; DNA ISOLATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPORAL LOBE EPILEPSY; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; SEXUAL DEVELOPMENT;

ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CHINA; EPILEPSY, TEMPORAL LOBE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; HUMANS; MALE; NEUREGULIN-1; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS;

EID: 84957886969     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073815589757     Document Type: Article

References (39)

1. Ngugi AK, Bottomley C, Kleinschmidt I, et al. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia. 2010; 51: 883-890.
2. World Health Organization. Epilepsy: Fact Sheet No 999. 2012. http://www.who.int/mediacentre/factsheets/fs999/en/index.
3. Hildebrand MS, Dahl HH, Damiano JA, et al. Recent advances in the molecular genetics of epilepsy. J Med Genet. 2013; 50: 271-279.
4. Thomas RH, Berkovic SF,. The hidden genetics of epilepsy-a clinically important new paradigm. Nat Rev Neurol. 2014; 10: 283-292.
5. Mei L, Nave KA,. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron. 2014; 83: 27-49.
6. Wen L, Lu YS, Zhu XH, et al. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A. 2010; 107: 1211-1216.
7. Eilam R, Pinkas-Kramarski R, Ratzkin BJ, et al. Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain. Proc Natl Acad Sci U S A. 1998; 95: 1888-1893.
8. Ozaki M, Itoh K, Miyakawa Y, et al. Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner. J Neurochem. 2004; 91: 176-188.
9. Cascella NG, Schretlen DJ, Sawa A,. Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res. 2009; 63: 227-235.
10. Deng C, Pan B, Engel M, et al. Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway. Psychopharmacology. 2013; 226: 201-215.
11. Li KX, Lu YM, Xu ZH, et al. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy. Nat Neurosci. 2012; 15: 267-273.
12. Tan GH, Liu YY, Hu XL, et al. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci. 2012; 15: 258-266.
13. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989; 30: 389-399.
14. Bob P, Palus M, Susta M, et al. Sensitization, epileptic-like symptoms and local synchronization in patients with paranoid schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010; 34: 143-146.
15. Qin P, Xu H, Laursen TM, et al. Risk for schizophrenia and schizophrenia-like psychosis among patients with epilepsy: population based cohort study. BMJ. 2005; 331: 23.
16. Dedeurwaerdere S, Boets S, Janssens P, et al. In the grey zone between epilepsy and schizophrenia: alterations in group II metabotropic glutamate receptors. Acta Neurol Belg. 2014 25.
17. Schmitt A, Koschel J, Zink M, et al. Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2010; 260: 101-111.
18. Amini E, Rezaei M, Mohamed Ibrahim N, et al. A molecular approach to epilepsy management: from current therapeutic methods to preconditioning efforts. Mol Neurobiol. 2014 9.
19. Hansen KB, Mullasseril P, Dawit S, et al. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N -methyl- d -aspartate receptor antagonists. J Pharmacol Exp Ther. 2010; 333: 650-662.
20. Moddel G, Jacobson B, Ying Z, et al. The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain Res. 2005; 1046: 10-23.
21. Yen W, Williamson J, Bertram EH, et al. A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. Epilepsy Res. 2004; 59: 43-50.
22. Hanada T, Hashizume Y, Tokuhara N, et al. Perampanel: a novel, orally active, noncompetitive AMPA-receptor antagonist that reduces seizure activity in rodent models of epilepsy. Epilepsia. 2011; 2: 1331-1340.
23. Barton ME, Steve White H,. The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression. Epilepsy Res. 2004; 59: 1-12.
24. Pitcher GM, Kalia LV, Ng D, et al. Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors. Nat Med. 2011; 17: 470-478.
25. Bennett M,. Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. Aust NZ Psychiat. 2009; 43: 711-721.
26. Kotsopoulos IA, van Merode T, Kessels FG, et al. Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia. 2002; 43: 1402-1409.
27. Verrotti A, Laus M, Coppola G, et al. Catamenial epilepsy: hormonal aspects. Gynecol Endocrinol. 2010; 26: 783-790.
28. Miyagawa S, Katsu Y, Watanabe H, et al. Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol. Oncogene. 2004; 23: 340-349.
29. Lacroix-Fralish ML, Tawfik VL, Nutile-McMenemy N, et al. Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: implications for sex specific pain modulation. Eur J Pain. 2008; 12: 94-103.
30. Li D, Collier DA, He L,. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet. 2006; 15: 1995-2002.
31. Prata DP, Breen G, Osborne S, et al. An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis. Psychiatr Genet. 2009; 19: 113-116.
32. Moon E, Rollins B, Mesen A, et al. Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population. Schizophr Res. 2011; 131: 52-57.
33. Paterson C, Wang Y, Kleinman JE, Law AJ,. Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry. 2014; 171: 979-989.
34. Fazzari P, Paternain AV, Valiente M, et al. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. 2010; 464: 1376-1380.
35. Woo RS, Li XM, Tao Y, et al. Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 2007; 54: 599-610.
36. Iyengar SS, Mott DD,. Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus. Brain Res. 2008; 1208: 67-73.
37. Backx L, Ceulemans B, Vermeesch JR, et al. Early myoclonic encephalopathy caused by a disruption of the neuregulin-1 receptor ErbB4. Eur J Hum Genet. 2009; 17: 378-382.
38. Dai AI, Akcali A, Koska S, et al. Contribution of KCNJ10 gene polymorphisms in childhood epilepsy. J Child Neurol. 2014; 30: 296-300.
39. Maljevic S, Lerche H,. Potassium channel genes and benign familial neonatal epilepsy. Prog Brain Res. 2014; 213: 17-53.