Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder

Journal of Autism and Developmental Disorders

Volumn 46, Issue 3, 2016, Pages 1124-1130

  Marler, Sarah ^a   Ferguson, Bradley J ^b   Lee, Evon Batey ^a   Peters, Brittany ^a   Williams, Kent C ^c   McDonnell, Erin ^d   Macklin, Eric A ^d   Levitt, Pat ^e,f   Gillespie, Catherine Hagan ^g   Anderson, George M ^h   Margolis, Kara Gross ⁱ   Beversdorf, David Q ^b   Veenstra VanderWeele, Jeremy ^i,j,k  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e CHILDREN S HOSPITAL LOS ANGELES   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g UNIVERSITY OF MISSOURI   (United States)

^h YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ Och Spine at New York Presbyterian Hospitals   (United States)

^j NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^k NEW YORK PRESBYTERIAN HOSPITAL   (United States)

more..

Author keywords

5 HT; Autism Treatment Network; Gastrointestinal (GI); IL 6; Medical comorbidities; Serotonin

Indexed keywords

INTERLEUKIN 6; SEROTONIN; BIOLOGICAL MARKER;

ADOLESCENT; ARTICLE; AUTISM; BEHAVIOR ASSESSMENT; BLOOD ANALYSIS; CHILD; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONSTIPATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERSEROTONEMIA; INTESTINE FUNCTION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MICROBIOME; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SEROTONIN BLOOD LEVEL; SEROTONIN SYNDROME; AUTISM SPECTRUM DISORDER; BLOOD; GASTROINTESTINAL DISEASES; QUESTIONNAIRE;

ADOLESCENT; AUTISM SPECTRUM DISORDER; BIOMARKERS; CHILD; CONSTIPATION; FEMALE; GASTROINTESTINAL DISEASES; HUMANS; MALE; SEROTONIN; SURVEYS AND QUESTIONNAIRES;

EID: 84957851378     PISSN: 01623257     EISSN: 15733432     Source Type: Journal    
DOI: 10.1007/s10803-015-2646-8     Document Type: Article

References (24)

1. Aldinger, K. A., Lane, C. J., Veenstra-VanderWeele, J., & Levitt, P. (2015). Patterns of Risk for multiple co-occurring medical conditions replicate across distinct cohorts of children with autism spectrum disorder. Autism Research,. doi:10.1002/aur.1492.
2. Aman, M. (1994). Aberrant Behavior Checklist - Community. East Aurora, NY: Slosson Educational Publications.
3. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders-text revision (DSM-IV-TR) (4th ed.). Washington, DC: American Psychiatric Association Press, Inc.
4. Anderson, G. M., Feibel, F. C., & Cohen, D. J. (1987). Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Science,40, 1063–1070.
5. Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I., & Van de Water, J. (2011). Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain, Behavior, and Immunity,25(1), 40–45. doi:10.1016/j.bbi.2010.08.003.
6. Baber, K. F., Anderson, J., Puzanovova, M., & Walker, L. S. (2008). Rome II versus Rome III classification of functional gastrointestinal disorders in pediatric chronic abdominal pain. Journal of Pediatric Gastroenterology and Nutrition,47(3), 299–302. doi:10.1097/MPG.0b013e31816c4372.
7. Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243. Retrieved from http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=0011055459.
8. Chaidez, V., Hansen, R. L., & Hertz-Picciotto, I. (2014). Gastrointestinal problems in children with autism, developmental delays or typical development. Journal of Autism and Developmental Disorders,44(5), 1117–1127. doi:10.1007/s10803-013-1973-x.
9. Chandler, S., Carcani-Rathwell, I., Charman, T., Pickles, A., Loucas, T., Meldrum, D., & Baird, G. (2013). Parent-reported gastro-intestinal symptoms in children with autism spectrum disorders. Journal of Autism and Developmental Disorders,43(12), 2737–2747. doi:10.1007/s10803-013-1768-0.
10. Gabriele, S., Sacco, R., & Persico, A. M. (2014). Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis. European Neuropsychopharmacology,24(6), 919–929. doi:10.1016/j.euroneuro.2014.02.004.
11. Gershon, M. D. (2013). 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Current opinion in Endocrinology, Diabetes, and Obesity,20(1), 14–21. doi:10.1097/MED.0b013e32835bc703.
12. Gorrindo, P., Williams, K. C., Lee, E. B., Walker, L. S., McGrew, S. G., & Levitt, P. (2012). Gastrointestinal dysfunction in autism: Parental report, clinical evaluation, and associated factors. Autism Research,5(2), 101–108. doi:10.1002/aur.237.
13. Ibrahim, S. H., Voigt, R. G., Katusic, S. K., Weaver, A. L., & Barbaresi, W. J. (2009). Incidence of gastrointestinal symptoms in children with autism: A population-based study. Pediatrics,124(2), 680–686. doi:10.1542/peds.2008-2933.
14. Kolevzon, A., Newcorn, J. H., Kryzak, L., Chaplin, W., Watner, D., Hollander, E., & Silverman, J. M. (2010). Relationship between whole blood serotonin and repetitive behaviors in autism. Psychiatry Research,175(3), 274–276. doi:10.1016/j.psychres.2009.02.008.
15. Li, Z., Chalazonitis, A., Huang, Y. Y., Mann, J. J., Margolis, K. G., Yang, Q. M., & Gershon, M. D. (2011). Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. Journal of Neuroscience,31(24), 8998–9009. doi:10.1523/JNEUROSCI.6684-10.2011.
16. Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism Diagnostic Observation Schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders,19, 185–212.
17. Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2015). Cytokine aberrations in autism spectrum disorder: A systematic review and meta-analysis. Molecular Psychiatry,20(4), 440–446. doi:10.1038/mp.2014.59.
18. McBride, P. A., Anderson, G. M., Hertzig, M. E., Snow, M. E., Thompson, S. M., Khait, V. D., & Cohen, D. J. (1998). Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. Journal of the American Academy of Child and Adolescent Psychiatry,37(7), 767–776. doi:10.1097/00004583-199807000-00017.
19. McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics,133(5), 872–883. doi:10.1542/peds.2013-3995.
20. Mulder, E. J., Anderson, G. M., Kema, I. P., de Bildt, A., van Lang, N. D., den Boer, J. A., & Minderaa, R. B. (2004). Platelet serotonin levels in pervasive developmental disorders and mental retardation: Diagnostic group differences, within-group distribution, and behavioral correlates. Journal of the American Academy of Child and Adolescent Psychiatry,43(4), 491–499. doi:10.1097/00004583-200404000-00016.
21. Sacco, R., Curatolo, P., Manzi, B., Militerni, R., Bravaccio, C., Frolli, A., & Persico, A. M. (2010). Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Research,3(5), 237–252. doi:10.1002/aur.151.
22. Schoen, S. A., Miller, L. J., & Green, K. E. (2008). Pilot study of the Sensory Over-Responsivity Scales: Assessment and inventory. American Journal of Occupational Therapy, 62(4), 393–406. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18712002.
23. Yang, C. J., Liu, C. L., Sang, B., Zhu, X. M., & Du, Y. J. (2015). The combined role of serotonin and interleukin-6 as biomarker for autism. Neuroscience,284, 290–296. doi:10.1016/j.neuroscience.2014.10.011.
24. Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., …, Hsiao, E. Y. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 161(2), 264–276. doi:10.1016/j.cell.2015.02.047.