Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b

Alzheimer's and Dementia

Volumn 12, Issue 2, 2016, Pages 130-143

  Liu, Hui ^a   Qiu, Hongyan ^a   Yang, Juan ^a   Ni, Jun ^a   Le, Weidong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Chronic hypoxia; DNA methylation; DNMT3a; DNMT3b; amyloid; secretase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DNA METHYLTRANSFERASE 3B; GAMMA SECRETASE; GENOMIC DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; SECRETASE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; GENE OVEREXPRESSION; HYPOXIA; IN VIVO STUDY; LEARNING AND MEMORY TEST; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANOXIA; BRAIN; COMPLICATION; DISEASE MODEL; DOWN REGULATION; GENETICS; MEMORY; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANOXIA; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DOWN-REGULATION; MEMORY; MICE; MICE, TRANSGENIC;

EID: 84957843114     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.05.019     Document Type: Article

References (59)

1. R.H. Swerdlow Pathogenesis of Alzheimer's disease Clin Interv Aging 2 2007 347 359
2. R.J. O'Brien, and P.C. Wong Amyloid precursor protein processing and Alzheimer's disease Annu Rev Neurosci 34 2011 185 204
3. M. Goedert, and M.G. Spillantini A century of Alzheimer's disease Science 314 2006 777 781
4. M.C. Carrillo, A. Blackwell, H. Hampel, J. Lindborg, R. Sperling, D. Schenk, and et al. Early risk assessment for Alzheimer's disease Alzheimers Dement 5 2009 182 196
5. J. Povova, P. Ambroz, M. Bar, V. Pavukova, O. Sery, H. Tomaskova, and et al. Epidemiological of and risk factors for Alzheimer's disease: A review Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 156 2012 108 114
6. L. Li, X. Zhang, D. Yang, G. Luo, S. Chen, and W. Le Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP Neurobiol Aging 30 2009 1091 1098
7. X. Zhang, and W. Le Pathological role of hypoxia in Alzheimer's disease Exp Neurol 223 2010 299 303
8. X. Zhang, L. Li, X. Zhang, W. Xie, L. Li, D. Yang, and et al. Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice Neurobiol Aging 34 2013 663 678
9. C. Michiels Physiological and pathological responses to hypoxia Am J Pathol 164 2004 1875 1882
10. C.S. Ivan, S. Seshadri, A. Beiser, R. Au, C.S. Kase, M. Kelly-Hayes, and et al. Dementia after stroke: The Framingham Study Stroke 35 2004 1264 1268
11. G.M. Savva, and B.C. Stephan Epidemiological studies of the effect of stroke on incident dementia: A systematic review Stroke 41 2010 e41 e46
12. S. Ukraintseva, F. Sloan, K. Arbeev, and A. Yashin Increasing rates of dementia at time of declining mortality from stroke Stroke 37 2006 1155 1159
13. K. Yaffe, A.M. Laffan, S.L. Harrison, S. Redline, A.P. Spira, K.E. Ensrud, and et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women JAMA 306 2011 613 619
14. N.N. Nalivaeva, N.D. Belyaev, C. Kerridge, and A.J. Turner Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease Front Aging Neurosci 6 2014 235
15. N.N. Nalivaevaa, L. Fisk, E.G. Kochkina, S.A. Plesneva, I.A. Zhuravin, E. Babusikova, and et al. Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes Ann N Y Acad Sci 1035 2004 21 33
16. O. Aguilera, A.F. Fernández, A. Muñoz, and M.F. Fraga Epigenetics and environment: A complex relationship 109 2010 243 251
17. Z. Wang, D. Yang, X. Zhang, T. Li, J. Li, Y. Tang, and et al. Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons PLoS One 6 2011 e19229
18. Z. Wang, X.J. Zhang, T. Li, J. Li, Y. Tang, and W. Le Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe)/PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin CNS Neurosci Ther 20 2014 209 217
19. L.C. Li, and R. Dahiya MethPrimer: Designing primers for methylation PCRs Bioinformatics 18 2002 1427 1431
20. D. Takai, and P.A. Jones The CpG island searcher: A new WWW resource In Silico Biol 3 2003 235 240
21. C. Bock, S. Reither, T. Mikeska, M. Paulsen, J. Walter, and T. Lengauer BiQ Analyzer: Visualization and quality control for DNA methylation data from bisulfite sequencing Bioinformatics 21 2005 4067 4068
22. M. Okano, S. Xie, and E. Li Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells Nucleic Acids Res 26 1998 2536 2540
23. M. Karahoca, and R.L. Momparler Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy Clin Epigenetics 5 2013 3
24. R.N. Kalaria Vascular basis for brain degeneration: Faltering controls and risk factors for dementia Nutr Rev 68 Suppl 2 2010 S74 S87
25. B.V. Zlokovic New therapeutic targets in the neurovascular pathway in Alzheimer's disease Neurotherapeutics 5 2008 409 414
26. B.V. Zlokovic Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Nat Rev Neurosci 12 2011 723 738
27. R.D. Bell, E.A. Winkler, A.P. Sagare, I. Singh, B. LaRue, R. Deane, and et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging Neuron 68 2010 409 427
28. A. Armulik, G. Genove, M. Mae, M.H. Nisancioglu, E. Wallgard, C. Niaudet, and et al. Pericytes regulate the blood-brain barrier Nature 468 2010 557 561
29. P.J. Landrigan, B. Sonawane, R.N. Butler, L. Trasande, R. Callan, and D. Droller Early environmental origins of neurodegenerative disease in later life Environ Health Perspect 113 2005 1230 1233
30. P.H. Tate, and A.P. Bird Effects of DNA methylation on DNA-binding proteins and gene expression Curr Opin Genet Dev 3 1993 226 231
31. P.A. Jones Functions of DNA methylation: Islands, start sites, gene bodies and beyond Nat Rev Genet 13 2012 484 492
32. F. Antequera, and A. BiRD Number of CpG islands and genes in human and mouse Proc Natl Acad Sci U S A 90 1993 11995 11999
33. P.A. Jones, and D. Takai The role of DNA methylation in mammalian epigenetics Science 293 2001 1068 1070
34. K.D. Robertson DNA methylation and human disease Nat Rev Genet 6 2005 597 610
35. A. Portela, and M. Esteller Epigenetic modifications and human disease Nat Biotechnol 28 2010 1057 1068
36. A. Fuso, L. Seminara, R.A. Cavallaro, F. D'Anselmi, and S. Scarpa S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production Mol Cell Neurosci 28 2005 195 204
37. R.L. West, J.M. Lee, and L.E. Maroun Maroun Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient J Mol Neurosci 6 1995 141 146
38. S.C. Wang, B. Oelze, and A. Schumacher Age-specific epigenetic drift in late-onset Alzheimer's disease PLoS One 3 2008 e2698
39. J. Wu, M.R. Basha, B. Brock, D.P. Cox, F. Cardozo-Pelaez, C.A. McPherson, and et al. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD J Neurosci 28 2008 3 9
40. S.W. Bihaqi, H. Huang, J. Wu, and N.H. Zawia Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease J Alzheimers Dis 27 2011 819 833
41. X. Cheng, and R.M. Blumenthal Mammalian DNA methyltransferases: A structural perspective Structure 16 2008 341 350
42. E. Li, C. Beard, and R. Jaenisch Role for DNA methylation in genomic imprinting Nature 366 1993 362 365
43. M.G. Goll, F. Kirpekar, K.A. Maggert, J.A. Yoder, C.L. Hsieh, X. Zhang, and et al. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2 Science 311 2006 395 398
44. M. Okano, D.W. Bell, D.A. Haber, and E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257
45. D. Bourc'his, G.L. Xu, C.S. Lin, B. Bollman, and T.H. Bestor Dnmt3L and the establishment of maternal genomic imprints Science 294 2001 2536 2539
46. F. Chédin, M.R. Lieber, and C.L. Hsieh The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a Proc Natl Acad Sci U S A 99 2002 16916 16921
47. C.A. Miller, and J.D. Sweatt Covalent modification of DNA regulates memory formation Neuron 53 2007 857 869
48. J. Feng, Y. Zhou, S.L. Campbell, T. Le, E. Li, J.D. Sweatt, and et al. Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons Nat Neurosci 13 2010 423 430
49. V.L. Wilson, R. Smith, S. Ma, and R. Cutler Genomic 5-methyldeoxycytidine decreases with age J Biol Chem 262 1987 9948 9951
50. V. Bollati, J. Schwartz, R. Wright, A. Litonjua, L. Tarantini, H. Suh, and et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects Mech Ageing Dev 130 2009 234 239
51. V.L. Wilson, and P.A. Jones DNA methylation decreases in aging but not in immortal cells Science 220 1983 1055 1057
52. A.M. Oliveira, T.J. Hemstedt, and H. Bading Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities Nat Neurosci 15 2012 1111 1113
53. I. Hartley, F.F. Elkhoury, J.H. Shin, B. Xie, X. Gu, Y. Gao, and et al. Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures PLoS One 8 2013 e77859
54. K. Skowronski, S. Dubey, D.I. Rodenhiser, and B. Coomber Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells Epigenetics 5 2010 547 556
55. L. Xiong, F. Wang, X. Huang, Z.H. Liu, T. Zhao, L.Y. Wu, and et al. DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia FEBS J 279 2012 4318 4326
56. S. Engelhardt, S. Patkar, and O. Ogunshola Cell-specific blood-brain barrier regulation in health and disease: A focus on hypoxia Br J Pharmacol 171 2014 1210 1230
57. E. Gonul, B. Duz, S. Kahraman, H. Kayali, A. Kubar, and E. Timurkaynak Early pericyte response to brain hypoxia in cats: An ultrastructural study Microvasc Res 64 2002 116 119
58. E.A. Winkler, A.P. Sagare, and B.V. Zlokovic The pericyte: A forgotten cell type with important implications for Alzheimer's disease? Brain Pathol 24 2014 371 386
59. J.I. Perez-Perri, J.M. Acevedo, and P. Wappner Epigenetics: New questions on the response to hypoxia Int J Mol Sci 12 2011 4705 4721