Association of serum C3 concentration and histologic signs of thrombotic microangiopathy with outcomes among patients with ANCA-associated renal vasculitis

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 12, 2015, Pages 2143-2151

  Manenti, Lucio ^a   Vaglio, Augusto ^a   Gnappi, Elisa ^a   Maggiore, Umberto ^a   Allegri, Landino ^a   Allinovi, Marco ^a   Urban, Maria L ^a   Delsante, Marco ^a   Galetti, Maricla ^a   Nicastro, Maria ^a   Pilato, Francesco P ^a   Buzio, Carlo ^a  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYCLOPHOSPHAMIDE; FRESH FROZEN PLASMA; METHOTREXATE; METHYLPREDNISOLONE; MYELOBLASTIN; MYELOPEROXIDASE; PLATELET DERIVED GROWTH FACTOR BB; PREDNISONE; BIOLOGICAL MARKER; C3 PROTEIN, HUMAN;

ADULT; AGED; ANCA ASSOCIATED RENAL VASCULITIS; ANCA ASSOCIATED VASCULITIS; ARTICLE; ASSESSMENT OF HUMANS; BIRMINGHAM VASCULITIS ACTIVITY SCORE; CLINICAL ARTICLE; COMPLEMENT ALTERNATIVE PATHWAY; DEATH CENSORED RENAL SURVIVAL; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; MALE; MIDDLE AGED; PLASMAPHERESIS; SURVIVAL; THROMBOTIC THROMBOCYTOPENIC PURPURA; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; BIOPSY; BLOOD; COMPLEMENT ACTIVATION; COMPLICATION; DISEASE COURSE; DOWN REGULATION; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; ITALY; KAPLAN MEIER METHOD; KIDNEY; KIDNEY DISEASES; KIDNEY FAILURE, CHRONIC; MORTALITY; PATHOLOGY; PROGNOSIS; RETROSPECTIVE STUDY; RISK FACTOR; THROMBOTIC MICROANGIOPATHIES; TIME FACTOR; UNIVERSITY HOSPITAL; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; BIOMARKERS; BIOPSY; COMPLEMENT ACTIVATION; COMPLEMENT C3; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HOSPITALS, UNIVERSITY; HUMANS; ITALY; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY DISEASES; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; THROMBOTIC MICROANGIOPATHIES; TIME FACTORS;

EID: 84957800791     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.00120115     Document Type: Article

References (18)

1. Jennette JC, Falk RJ, Hu P, Xiao H: Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis. Annu Rev Pathol 8: 139-160, 2013.
2. Kettritz R: With complements from ANCA mice. J Am Soc Nephrol 25: 207-209, 2014.
3. Jennette JC, Wilkman AS, Falk RJ: Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol 135: 921-930, 1989.
4. Xiao H, Schreiber A, Heeringa P, Falk RJ, Jennette JC: Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies. Am J Pathol 170: 52-64, 2007.
5. Huugen D, van Esch A, Xiao H, Peutz-Kootstra CJ, Buurman WA, Tervaert JW, Jennette JC, Heeringa P: Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice. Kidney Int 71: 646-654, 2007.
6. Schreiber A, Xiao H, Jennette JC, Schneider W, Luft FC, Kettritz R: C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis. J Am Soc Nephrol 20: 289-298, 2009.
7. Xing GQ, Chen M, Liu G, Heeringa P, Zhang JJ, Zheng X, Jie E, Kallenberg CG, Zhao MH: Complement activation is involved in renal damage in human antineutrophil cytoplasmic autoantibody associated pauci-immune vasculitis. J Clin Immunol 29: 282-291, 2009.
8. Chen M, Xing GQ, Yu F, Liu G, Zhao MH: Complement deposition in renal histopathology of patients with ANCA-associated pauciimmune glomerulonephritis. Nephrol Dial Transplant 24: 1247-1252, 2009.
9. Gou SJ, Yuan J, Chen M, Yu F, Zhao MH: Circulating complement activation in patients with anti-neutrophil cytoplasmic antibodyassociated vasculitis. Kidney Int 83: 129-137, 2013.
10. Manenti L, Gnappi E, Vaglio A, Allegri L, Noris M, Bresin E, Pilato FP, Valoti E, Pasquali S, Buzio C: Atypical haemolytic uraemic syndrome with underlying glomerulopathies. A case series and a reviewof the literature. Nephrol Dial Transplant 28: 2246-2259, 2013.
11. Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration: Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem 53: 766-772, 2007.
12. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA: 2012 Revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65: 1-11, 2013.
13. Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, Neumann I, Noël LH, Pusey CD, Waldherr R, Bruijn JA, Bajema IM: Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21: 1628-1636, 2010.
14. Gou SJ, Yuan J, Wang C, Zhao MH, Chen M: Alternative complement pathway activation products in urine and kidneys of patients with ANCA-associated GN. Clin J Am Soc Nephrol 8: 1884-1891, 2013.
15. Molad Y, Tovar A, Ofer-Shiber S: Association of low serum complement C3 with reduced patient and renal survival in antimyeloperoxidase-associated small-vessel vasculitis. Nephron Clin Pract 126: 67-74, 2014.
16. Xing GQ, Chen M, Liu G, Zheng X, Jie E, Zhao MH: Differential deposition of C4d and MBL in glomeruli of patients with ANCAnegative pauci-immune crescentic glomerulonephritis. J Clin Immunol 30: 144-156, 2010.
17. Cohen D, Koopmans M, Kremer Hovinga IC, Berger SP, Roos van Groningen M, Steup-Beekman GM, de Heer E, Bruijn JA, Bajema IM: Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis. Arthritis Rheum 58: 2460-2469, 2008.
18. Xiao H, Dairaghi DJ, Powers JP, Ertl LS, Baumgart T, Wang Y, Seitz LC, Penfold ME, Gan L, Hu P, Lu B, Gerard NP, Gerard C, Schall TJ, Jaen JC, Falk RJ, Jennette JC: C5a receptor (CD88) blockade protects against MPO-ANCA GN. J Am Soc Nephrol 25: 225-231, 2014.