Antibiotics detected in urines and adipogenesis in school children

Environment International

Volumn 89-90, Issue , 2016, Pages 204-211

  Wang, Hexing ^a   Wang, Na ^a   Wang, Bin ^a   Fang, Hong ^b   Fu, Chaowei ^a   Tang, Chuanxi ^c   Jiang, Feng ^a   Zhou, Ying ^a   He, Gengsheng ^a   Zhao, Qi ^a   Chen, Yue ^d   Jiang, Qingwu ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Minhang District Hospital   (China)

^c Changning District Center for Disease Control and Prevention   (China)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Antibiotics; Biomonitoring; Obesity; School children; Urine; Use

Indexed keywords

AMIDES; FREE FLIGHT; LIQUID CHROMATOGRAPHY; LOGISTIC REGRESSION; MASS SPECTROMETRY; NUTRITION; POTABLE WATER; SULFUR COMPOUNDS;

BIOMONITORING; CROSS-SECTIONAL DESIGN; MULTINOMIAL LOGISTIC REGRESSION; OBESITY; QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; SCHOOL CHILDREN; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINE;

ANTIBIOTICS;

AMPICILLIN; ANTIBIOTIC AGENT; AZITHROMYCIN; CEFACLOR; CHLORAMPHENICOL; CHLORTETRACYCLINE; CIPROFLOXACIN; CLARITHROMYCIN; ENROFLOXACIN; ERYTHROMYCIN; FLORFENICOL; NORFLOXACIN; OFLOXACIN; OXYTETRACYCLINE; ROXITHROMYCIN; SULFADIAZINE; SULFADIMIDINE; SULFAMETHOXAZOLE; TETRACYCLINE; THIAMPHENICOL; TRIMETHOPRIM; TYLOSIN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER;

ANTIBIOTICS; BIOMONITORING; CHILD HEALTH; OBESITY; URINE;

ADIPOGENESIS; ARTICLE; BIOLOGICAL MONITORING; BODY MASS; CHILD; CHILDHOOD OBESITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EXPOSURE; DRUG URINE LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; INTESTINE FLORA; LIMIT OF DETECTION; MALE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SEX DIFFERENCE; TIME OF FLIGHT MASS SPECTROMETRY; VETERINARY MEDICINE; WAIST CIRCUMFERENCE; WATER CONTAMINATION; CHINA; CROSS-SECTIONAL STUDY; DRUG EFFECTS; ENVIRONMENTAL MONITORING; OBESITY; OVERWEIGHT; PROCEDURES; RISK; URINE;

CHINA; SHANGHAI;

ADIPOGENESIS; ADIPOSITY; ANTI-BACTERIAL AGENTS; BIOMARKERS; BODY MASS INDEX; CHILD; CHINA; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MALE; OBESITY; OVERWEIGHT; RISK; WAIST CIRCUMFERENCE;

EID: 84957796730     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2016.02.005     Document Type: Article

References (30)

1. Ajslev T.A., Andersen C.S., Gamborg M., Sorensen T.I., Jess T. Childhood overweight after establishment of the gut microbiota: The role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int. J. Obes. 2011, 35(4):522-529.
2. Azad M.B., Bridgman S.L., Becker A.B., Kozyrskyj A.L. Infant antibiotic exposure and the development of childhood overweight and central adiposity. Int. J. Obes. 2014, 38(10):1290-1298.
3. Bailey L.C., Forrest C.B., Zhang P., Richards T.M., Livshits A., Derusso P.A. Association of antibiotics in infancy with early childhood obesity. JAMA Pediatr. 2014, 168(11):1063-1069.
4. Bu Q., Wang B., Huang J., Deng S., Yu G. Pharmaceuticals and personal care products in the aquatic environment in China: a review. J. Hazard. Mater. 2013, 262:189-211.
5. Casals-Casas C., Desvergne B. Endocrine disruptors: from endocrine to metabolic disruption. Annu. Rev. Physiol. 2011, 73:135-162.
6. Castanon J.I. History of the use of antibiotic as growth promoters in European poultry feeds. Poult. Sci. 2007, 86(11):2466-2471.
7. Cho I., Yamanishi S., Cox L., Methe B.A., Zavadil J., Li K., Gao Z., Mahana D., Raju K., Teitler I., Li H., Alekseyenko A.V., Blaser M.J. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 2012, 488(7413):621-626.
8. Cox L.M., Blaser M.J. Antibiotics in early life and obesity. Nat. Rev. Endocrinol. 2014, 11(3):182-190.
9. Cox L.M., Yamanishi S., Sohn J., Alekseyenko A.V., Leung J.M., Cho I., Kim S.G., Li H., Gao Z., Mahana D., Zarate R.J., Rogers A.B., Robine N., Loke P., Blaser M.J. Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 2014, 158(4):705-721.
10. Cunha B.A. Antibiotic Essentials 2013, 2013. Jones and Bartlett Publishers, Inc., Burlington, MA. 10th ed.
11. Dibner J.J., Richards J.D. Antibiotic growth promoters in agriculture: history and mode of action. Poult. Sci. 2005, 84(4):634-643.
12. Ji C.Y. Report on childhood obesity in China (1)-body mass index reference for screening overweight and obesity in Chinese school-age children. Biomed. Environ. Sci. 2005, 18(6):390-400.
13. Ji K., Kho Y., Park C., Paek D., Ryu P., Paek D., Kim M., Kim P., Choi K. Influence of water and food consumption on inadvertent antibiotics intake among general population. Environ. Res. 2010, 110(7):641-649.
14. Ji C., Sung R.Y., Ma G., Ma J., He Z., Chen T. Waist circumference distribution of chinese school-age children and adolescents. Biomed. Environ. Sci. 2010, 23(1):12-20.
15. Ji K., Lim Kho Y., Park Y., Choi K. Influence of a five-day vegetarian diet on urinary levels of antibiotics and phthalate metabolites: a pilot study with "Temple stay" participants. Environ. Res. 2010, 110(4):375-382.
16. Leung H.W., Jin L., Wei S., Tsui M.M., Zhou B., Jiao L., Cheung P.C., Chun Y.K., Murphy M.B., Lam P.K. Pharmaceuticals in tap water: human health risk assessment and proposed monitoring framework in China. Environ. Health Perspect. 2013, 121(7):839-846.
17. Lin J. Effect of antibiotic growth promoters on intestinal microbiota in food animals: a novel model for studying the relationship between gut microbiota and human obesity?. Front. Microbiol. 2011, 2:53.
18. Liu J.L., Wong M.H. Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. Environ. Int. 2013, 59:208-224.
19. Markle J.G., Frank D.N., Mortin-Toth S., Robertson C.E., Feazel L.M., Rolle-Kampczyk U., von Bergen M., Mccoy K.D., Macpherson A.J., Danska J.S. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013, 339(6123):1084-1088.
20. Mueller S., Saunier K., Hanisch C., Norin E., Alm L., Midtvedt T., Cresci A., Silvi S., Orpianesi C., Verdenelli M.C., Clavel T., Koebnick C., Zunft H.F., Doré J., Blaut M. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl. Environ. Microbiol. 2005, 72(2):1027-1033.
21. Murphy R., Stewart A.W., Braithwaite I., Beasley R., Hancox R.J., Mitchell E.A. Antibiotic treatment during infancy and increased body mass index in boys: an international cross-sectional study. Int. J. Obes. 2014, 38(8):1115-1119.
22. Riley L.W., Raphael E., Faerstein E. Obesity in the United States - dysbiosis from exposure to low-dose antibiotics? Front. Public Health 2013, 1:69.
23. Schwiertz A., Taras D., Schafer K., Beijer S., Bos N.A., Donus C., Hardt P.D. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010, 18(1):190-195.
24. Trasande L., Blustein J., Liu M., Corwin E., Cox L.M., Blaser M.J. Infant antibiotic exposures and early-life body mass. Int. J. Obes. 2013, 37(1):16-23.
25. Vijay-Kumar M., Aitken J.D., Carvalho F.A., Cullender T.C., Mwangi S., Srinivasan S., Sitaraman S.V., Knight R., Ley R.E., Gewirtz A.T. Metabolic syndrome and altered gut microbiota in mice lacking Toll-Like receptor 5. Science 2010, 328(5975):228-231.
26. Wang H., Wng B., Zhou Y., Jiang Q. Rapid and sensitive screening and selective quantification of antibiotics in human urine by two-dimensional ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Anal. Bioanal. Chem. 2014, 406(3):8049-8058.
27. Wang H., Wang B., Zhao Q., Zhao Y., Fu C., Feng X., Wang N., Su M., Tang C., Jiang F., Zhou Y., Chen Y., Jiang Q. Antibiotic body burden of Chinese school children: a multisite biomonitoring-based study. Environ. Sci. Technol. 2015, 49(8):5070-5079.
28. Yan W., Yao H., Dai J., Cui J., Chen Y., Yang X., Harshfield G.A., Wang X. Waist circumference cutoff points in school-aged Chinese Han and Uygur children. Obesity (Silver Spring) 2008, 16(7):1687-1692.
29. Yatsunenko T., Rey F.E., Manary M.J., Trehan I., Dominguez-Bello M.G., Contreras M., Magris M., Hidalgo G., Baldassano R.N., Anokhin A.P., Heath A.C., Warner B., Reeder J., Kuczynski J., Caporaso J.G., Lozupone C.A., Lauber C., Clemente J.C., Knights D., Knight R., Gordon J.I. Human gut microbiome viewed across age and geography. Nature 2012, 486(7402):222-227.
30. Zhang Q.Q., Ying G.G., Pan C.G., Liu Y.S., Zhao J.L. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance. Environ. Sci. Technol. 2015, 49(11):6772-6782.