Carbapenemase-producing klebsiella pneumoniae in Romania: A six-month survey

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Lixandru, Brandusa Elena ^a   Cotar, Ani Ioana ^a,b   Straut, Monica ^a   Usein, Codruta Romanita ^a   Cristea, Dana ^a   Ciontea, Simona ^a   Tatu Chitoiu, Dorina ^a   Codita, Irina ^a   Rafila, Alexandru ^c   Nica, Maria ^d   Buzea, Mariana ^e   Baicus, Anda ^e   Ghita, Mihaela Camelia ^f   Nistor, Irina ^g   Tuchiluş, Cristina ^h   Indreas, Marina ⁱ   Antohe, Felicia ^j   Glasner, Corinna ^k   Grundmann, Hajo ^k   Jasir, Aftab ^b   Damian, Maria ^a   more..

^a CANTACUZINO INSTITUTE   (Romania)

^b EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ECDC   (Sweden)

^c Matei Bals National Institute of Infectious Diseases   (Romania)

^d VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

^e CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^f FUNDENI CLINICAL INSTITUTE   (Romania)

^g Clinic of Plastic Surgery Reconstructive Microsurgery and Burns   (Romania)

^h Laboratory of Immunology and Genetics   (Romania)

ⁱ Bacau Emergency County Hospital   (Romania)

^j INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^k UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMIPENEM; TEMOCILLIN; BACTERIAL PROTEIN; BETA LACTAMASE; CARBAPENEMASE;

ANATOMICAL SITE; ANATOMY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BLAKPC 2 GENE; BLANDM 1 GENE; BLAVIM 1 GENE; CARBAPENEMASE PRODUCING KLEBSIELLA PNEUMONIAE; CONTROLLED STUDY; DISK DIFFUSION; DNA SEQUENCE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC PROCEDURES; GENETIC VARIABILITY; GENOME MACRORESTRICTION FINGERPRINTING; GENOTYPE; INFECTION CONTROL; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; OXA 48 GENE; OXA 49 GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; ROMANIA; SEQUENCE HOMOLOGY; XBAI GENE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HOSPITAL; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; QUESTIONNAIRE;

BACTERIAL PROTEINS; BETA-LACTAMASES; ELECTROPHORESIS, GEL, PULSED-FIELD; HOSPITALS; HUMANS; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; PHENOTYPE; ROMANIA; SURVEYS AND QUESTIONNAIRES;

EID: 84957593307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0143214     Document Type: Article

References (31)

1. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tassios PT and Daikos GL. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an Evolving Crisis of Global Dimensions. Clin Microbiol Rev. 2012; 25: 682-707. doi: 10.1128/CMR.05035-11 PMID: 23034326
2. Glasner C, Albiger B, Buist G, Tambic AA, Cantón R, Carmeli Y, et al. the European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group. Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries, February 2013. Euro Surveill. 2013; 18 (28):pii = 20525.
3. Székely E, Damjanova I, Jánvári L, Vas KE, Molnár S, Bilca DV, et al. First description of blaNDM-1, blaOXA-48, blaOXA-181 producing Enterobacteriaceae strains in Romania. International Journal of Medical Microbiology. 2013; 303: 697-700. doi: 10.1016/j.ijmm.2013.10.001 PMID: 24183483
4. Gheorghe I, Czobor I, Chifiriuc MC, Borcan E, Ghita C, Banu O, et al. Molecular screening of carbapenemase-producing Gram-negative strains in Romanian intensive care units during a one year survey. Journal of Medical Microbiology. 2014; 63:1303-1310. doi: 10.1099/jmm.0.074039-0 PMID: 25060972
5. Hansen DS, Aucken HM, Abiola T, and Podschun R. Recommended Test Panel for Differentiation of Klebsiella Species on the Basis of a Trilateral Interlaboratory Evaluation of 18 Biochemical Tests. J Clin Microbiol. 2004; 42(8):3665-3669. PMID: 15297514
6. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and/or epidemiological importance, Version 1.0, December 2013. http://www.eucast.org/.
7. Nordmann P, Poirel L, Dortet L. Rapid Detection of Carbapenemase producing Enterobacteriaceae. Emerg Infect Dis. 2012; 18(9): 1503-1507. doi: 10.3201/eid1809.120355 PMID: 22932472
8. Poirel L, Heritier C, Tolu V, Nordmann P. Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 2004; 48:15-22. PMID: 14693513
9. Cuzon G, Naas T, Truong H, Villegas MV, Wisell KT, Carmeli Y, et al. Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene. Emerg Infect Dis. 2010; S16(9):1349-56.
10. Mavroidi A, Tsakris A, Tzelepi E, Pournaras S, Loukova V, Tzouvelekis LS. Carbapenem-hydrolysing VIM-2 metallo-ß-lactamase in Pseudomonas aeruginosa from Greece. J Antimicrob Chemother. 2000; 46(6):1041-1043. PMID: 11102432
11. Peirano G, Pillai DR, Pitondo-Silva A, Richardson D, Pitout JD. The characteristics of NDM-producing Klebsiella pneumoniae from Canada. Diagn Microbiol Infect Dis. 2011; 71(2):106-9. doi: 10.1016/j. diagmicrobio.2011.06.013 PMID: 21924993
12. Bratu S, Tolaney P, Karumudi U, Quale J, Mooty M, Nichani S, et al. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J Antimicrob Chemother. 2005; 56(1):128-32. PMID: 15917285
13. Pitout JD, Gregson DB, Poirel L, McClure JA, Le P, Church DL. Detection of Pseudomonas aeruginosa producing metallo-beta-lactamases in a large centralized laboratory. J Clin Microbiol. 2005; 43:3129-3135. PMID: 16000424
14. Standard Operating Procedure for PulseNet PFGE of Escherichia coli O157:H7, Escherichia coli non-O157 (STEC), Salmonella serotypes, Shigella sonnei and Shigella flexneri. PNL05 Last Updated April 2013.
15. Poirel L, Potron A, Nordmann P. OXA-48-like carbapenemase: the phantom menace. J Antimicrob Chemother. 2012; 67(7):1597-606. doi: 10.1093/jac/dks121 PMID: 22499996
16. Carrër A, Poirel L, Yilmaz M, Akan OA, Feriha C, Cuzon G, et al. Spread of OXA-48-encoding plasmid in Turkey and beyond. Antimicrob Agents Chemother. 2010; 54(3):1369-73. doi: 10.1128/AAC.01312-09 PMID: 20086157
17. Carrër A, Poirel L, Eraksoy H, Cagatay AA, Badur S, Nordmann P. Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob Agents Chemother. 2008; 52(8):2950-4. doi: 10.1128/AAC.01672-07 PMID: 18519712
18. Cuzon G, Ouanich J, Gondret R, Naas T, Nordmann P. Outbreak of OXA-48-positive carbapenemresistant Klebsiella pneumoniae isolates in France. Antimicrob Agents Chemother. 2011; 55(5):2420-3. doi: 10.1128/AAC.01452-10 PMID: 21343451
19. Pitart C, Solé M, Roca I, Fabrega A, Vila J, Marco F. First outbreak of a plasmid-mediated carbapenemhydrolyzing OXA-48 ß-lactamase in Klebsiella pneumoniae in Spain. Antimicrob Agents Chemother. 2011; 55(9):4398-401. doi: 10.1128/AAC.00329-11 PMID: 21746954
20. Voulgari E, Zarkotou O, Ranellou K, Karageorgopoulos DE, Vrioni G, Mamali V, et al. Outbreak of OXA-48 carbapenemase producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother. 2013; 68(1):84-8. doi: 10.1093/jac/dks356 PMID: 22945916
21. Potron A, Poirel L, Rondinaud E, Nordmann P. Intercontinental spread of OXA-48 beta-lactamase-producing Enterobacteriaceae over a 11-year period, 2001 to 2011. Eurosurveillance. 2013; 18(31): pii = 20549.
22. Berger S, Alauzet C, Aissa N, Hénard S, Rabaud C, Bonnet R, et al. Characterization of a new blaOXA-48-carrying plasmid in Enterobacteriaceae. Antimicrob. Agents Chemother. 2013; 57(8):4064-4067. doi: 10.1128/AAC.02550-12 PMID: 23733457
23. Poirel L, Dortet L, Bernabeu S, and Nordmann P. Genetic Features of blaNDM-1-Positive Enterobacteriaceae. Antimicrobial Agents And Chemotherapy. 2011; 55(11): 5403-5407. doi: 10.1128/AAC.00585-11 PMID: 21859933
24. Nordmann P, Naas T, and Poirel L. Global spread of carbapenemase producing Enterobacteriaceae. Emerging Infectious Diseases. 2011; 17(10): 1791-1798. doi: 10.3201/eid1710.110655 PMID: 22000347
25. Struelens MJ, Monnet DL, Magiorakos AP, Santos O'Connor F, Giesecke J, the European NDM-1 Survey Participants. New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: Emergence and response in Europe. Eurosurveillance. 2010; 15(46). pii: 19716.
26. Bogaerts P, Bouchahrouf W, de Castro RR, Deplano A, Berhin C, Pierard D, et al. Emergence of NDM-1-producing Enterobacteriaceae in Belgium. Antimicrob Agents Chemother. 2011; 55(6):3036-8. doi: 10.1128/AAC.00049-11 PMID: 21444697
27. Canton R, Akova M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, et al. European Network on Carbapenemases: Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012; 18:413-431. doi: 10.1111/j.1469-0691.2012.03821.x PMID: 22507109
28. Grundmann H, Livermore DM, Giske CG, Canton R, Rossolini GM, Campos J, et al. Carbapenem-nonsusceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts. Euro Surveill. 2010; 15(46): pii = 19711.
29. Wang XD, Cai JC, Zhou HW, Zhang R, Chen GX. Reduced susceptibility to carbapenems in Klebsiella pneumoniae clinical isolates associated with plasmid-mediated ß-lactamase production and OmpK36 porin deficiency. J Med Microbiol. 2009; 58:1196-1202. doi: 10.1099/jmm.0.008094-0 PMID: 19528170
30. Shin SY, Bae IK, Kim J, Jeong SH, Yong D, Yong D, et al. Resistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36. J Med Microbiol. 2012; 61: 239-245. doi: 10.1099/jmm.0.037036-0 PMID: 21940650
31. Council Recommendations of 15 November 2001 on the prudent use of antimicrobial agents in medicine (2002/77/EC). Official Journal of the European Communities 5.2.2002.