메뉴 건너뛰기




Volumn 115, Issue 2, 2016, Pages 368-381

Edoxaban: Impact on routine and specific coagulation assays: A practical laboratory guide

Author keywords

Coagulation tests; Drug measurement; Edoxaban; Factor Xa inhibitors; Guidelines

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10A INHIBITOR; EDOXABAN; FIBRINOGEN; LUPUS ANTICOAGULANT; PROTEIN C; PROTEIN S; RIVAROXABAN; BLOOD CLOTTING FACTOR 10A; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; THROMBIN;

EID: 84957585824     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-05-0415     Document Type: Article
Times cited : (63)

References (54)
  • 1
    • 84855477488 scopus 로고    scopus 로고
    • Long-term outcome after additional catheterdirected thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (The CaVenT study): A randomised controlled trial
    • Enden T, Haig Y, Klow NE, et al. Long-term outcome after additional catheterdirected thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial. Lancet 2012; 379: 31–38.
    • (2012) Lancet , vol.379 , pp. 31-38
    • Enden, T.1    Haig, Y.2    Klow, N.E.3
  • 2
    • 56549121367 scopus 로고    scopus 로고
    • Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis
    • Kahn SR, Shrier I, Julian JA, et al. Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med 2008; 149: 698–707.
    • (2008) Ann Intern Med , vol.149 , pp. 698-707
    • Kahn, S.R.1    Shrier, I.2    Julian, J.A.3
  • 3
    • 84874965043 scopus 로고    scopus 로고
    • Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency
    • Galanaud JP, Holcroft CA, Rodger MA, et al. Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency. J Thromb Haemost 2013; 11: 474–480.
    • (2013) J Thromb Haemost , vol.11 , pp. 474-480
    • Galanaud, J.P.1    Holcroft, C.A.2    Rodger, M.A.3
  • 4
    • 64349103170 scopus 로고    scopus 로고
    • Post-thrombotic syndrome: Prevalence, prognostication and need for progress
    • Prandoni P, Kahn SR. Post-thrombotic syndrome: prevalence, prognostication and need for progress. Br J Haematol 2009; 145: 286–295.
    • (2009) Br J Haematol , vol.145 , pp. 286-295
    • Prandoni, P.1    Kahn, S.R.2
  • 5
    • 45549091236 scopus 로고    scopus 로고
    • Determinants of health-related quality of life during the 2 years following deep vein thrombosis
    • Kahn SR, Shbaklo H, Lamping DL,et al. Determinants of health-related quality of life during the 2 years following deep vein thrombosis. J Thromb Haemost 2008; 6: 1105–1112.
    • (2008) J Thromb Haemost , vol.6 , pp. 1105-1112
    • Kahn, S.R.1    Shbaklo, H.2
  • 7
    • 84866852653 scopus 로고    scopus 로고
    • Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: Results from the REVERSE study
    • Chitsike RS, Rodger MA, Kovacs MJ, et al. Risk of post-thrombotic syndrome after subtherapeutic warfarin anticoagulation for a first unprovoked deep vein thrombosis: results from the REVERSE study. J Thromb Haemost 2012; 10: 2039–2044.
    • (2012) J Thromb Haemost , vol.10 , pp. 2039-2044
    • Chitsike, R.S.1    Rodger, M.A.2    Kovacs, M.J.3
  • 8
    • 64349117158 scopus 로고    scopus 로고
    • Subcommittee on Control of Anticoagulation of the S, Standardisation Committee of the International Society on T, Haemostasis. Definition of post-thrombotic syndrome of the leg for use in clinical investigations: A recommendation for standardisation
    • Kahn SR, Partsch H, Vedantham S, et al, Subcommittee on Control of Anticoagulation of the S, Standardisation Committee of the International Society on T, Haemostasis. Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardisation. J Thromb Haemost 2009; 7: 879–883.
    • (2009) J Thromb Haemost , vol.7 , pp. 879-883
    • Kahn, S.R.1    Partsch, H.2    Vedantham, S.3
  • 9
    • 19944392548 scopus 로고    scopus 로고
    • Revision of the CEAP classification for chronic venous disorders: Consensus statement
    • Eklof B, Rutherford RB, Bergan JJ, et al. Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg 2004; 40: 1248–1252.
    • (2004) J Vasc Surg , vol.40 , pp. 1248-1252
    • Eklof, B.1    Rutherford, R.B.2    Bergan, J.J.3
  • 10
    • 33644983392 scopus 로고    scopus 로고
    • Comparison of the Villalta and Ginsberg clinical scales to diagnose the post-thrombotic syndrome: Correlation with patient-reported disease burden and venous valvular reflux
    • Kahn SR, Desmarais S, Ducruet T, et al. Comparison of the Villalta and Ginsberg clinical scales to diagnose the post-thrombotic syndrome: correlation with patient-reported disease burden and venous valvular reflux. J Thromb Haemost 2006; 4: 907–908.
    • (2006) J Thromb Haemost , vol.4 , pp. 907-908
    • Kahn, S.R.1    Desmarais, S.2    Ducruet, T.3
  • 11
    • 84860475365 scopus 로고    scopus 로고
    • Prevalence and predictors for post-thrombotic syndrome 3 to 16 years after pregnancy-related venous thrombosis: A population-based, cross-sectional, case-control study
    • Wik HS, Jacobsen AF, Sandvik L, Sandset PM. Prevalence and predictors for post-thrombotic syndrome 3 to 16 years after pregnancy-related venous thrombosis: a population-based, cross-sectional, case-control study. J Thromb Haemost 2012; 10: 840–847.
    • (2012) J Thromb Haemost , vol.10 , pp. 840-847
    • Wik, H.S.1    Jacobsen, A.F.2    Sandvik, L.3    Sandset, P.M.4
  • 12
    • 0000398179 scopus 로고
    • Assessment of validity and reproducibility of a clinical scale for the post-thrombotic syndrome
    • Villalta S, Bagatella P, Piccioli A, Lensing A, Prins M, Prandoni P. Assessment of validity and reproducibility of a clinical scale for the post-thrombotic syndrome. Haemostasis 1994; 24: 158a.
    • (1994) Haemostasis , vol.24
    • Villalta, S.1    Bagatella, P.2    Piccioli, A.3    Lensing, A.4    Prins, M.5    Prandoni, P.6
  • 14
    • 84867276477 scopus 로고    scopus 로고
    • Interrater reliability: The kappa statistic
    • McHugh ML. Interrater reliability: the kappa statistic. Biochem Medica 2012; 22: 276–282.
    • (2012) Biochem Medica , vol.22 , pp. 276-282
    • McHugh, M.L.1
  • 15
    • 84896737250 scopus 로고    scopus 로고
    • Compression stockings to prevent postthrombotic syndrome: A randomised placebo-controlled trial
    • Kahn SR, Shapiro S, Wells PS, et al. Compression stockings to prevent postthrombotic syndrome: a randomised placebo-controlled trial. Lancet 2014; 383: 880–888.
    • (2014) Lancet , vol.383 , pp. 880-888
    • Kahn, S.R.1    Shapiro, S.2    Wells, P.S.3
  • 16
    • 84861699880 scopus 로고    scopus 로고
    • Comparison of the Villalta postthrombotic syndrome score in the ipsilateral vs. Contralateral leg after a first unprovoked deep vein thrombosis
    • Galanaud JP, Holcroft CA, Rodger MA, et al. Comparison of the Villalta postthrombotic syndrome score in the ipsilateral vs. contralateral leg after a first unprovoked deep vein thrombosis. J Thromb Haemost 2012; 10: 1036–1042.
    • (2012) J Thromb Haemost , vol.10 , pp. 1036-1042
    • Galanaud, J.P.1    Holcroft, C.A.2    Rodger, M.A.3
  • 18
    • 84884265697 scopus 로고    scopus 로고
    • Effect of long-term LMWH on post-thrombotic syndrome in patients with iliac/noniliac venous thrombosis: A subanalysis from the home-LITE study
    • Hull RD, Liang J, Merali T. Effect of long-term LMWH on post-thrombotic syndrome in patients with iliac/noniliac venous thrombosis: a subanalysis from the home-LITE study. Clin Appl Thromb Hemost 2013; 19: 476–481.
    • (2013) Clin Appl Thromb Hemost , vol.19 , pp. 476-481
    • Hull, R.D.1    Liang, J.2    Merali, T.3
  • 19
    • 84863482963 scopus 로고    scopus 로고
    • Value of patient self-assessment in the diagnosis and monitoring of post-thrombotic syndrome: The Patient-Tracked Symptoms questionnaire
    • Hull R, Butcher P. Value of patient self-assessment in the diagnosis and monitoring of post-thrombotic syndrome: the Patient-Tracked Symptoms questionnaire. Clin Appl Thromb Hemost 2012; 18: 345–350.
    • (2012) Clin Appl Thromb Hemost , vol.18 , pp. 345-350
    • Hull, R.1    Butcher, P.2
  • 20
    • 33746102144 scopus 로고    scopus 로고
    • The post-thrombotic syndrome: Progress and pitfalls
    • satfda_docs/nda/2012/202155Orig1s000ClinPharmR.pdf. Accessed May 5
    • Kahn SR. The post-thrombotic syndrome: progress and pitfalls. Br J Haematol 2006; 134: 357–365. satfda_docs/nda/2012/202155Orig1s000ClinPharmR.pdf. Accessed May 5, 2015.
    • (2006) Br J Haematol , vol.134 , pp. 357-365
    • Kahn, S.R.1
  • 21
    • 79960068693 scopus 로고    scopus 로고
    • Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time
    • Mani H, Hesse C, Stratmann G, et al. Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time. Thromb Haemost 2011; 106: 156–164.
    • (2011) Thromb Haemost , vol.106 , pp. 156-164
    • Mani, H.1    Hesse, C.2    Stratmann, G.3
  • 22
    • 79955480110 scopus 로고    scopus 로고
    • Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: Two observational studies in patients undergoing total hip or total knee replacement
    • Freyburger G, Macouillard G, Labrouche S, et al. Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: two observational studies in patients undergoing total hip or total knee replacement. Thromb Res 2011; 127: 457–465.
    • (2011) Thromb Res , vol.127 , pp. 457-465
    • Freyburger, G.1    Macouillard, G.2    Labrouche, S.3
  • 23
    • 84957603114 scopus 로고    scopus 로고
    • Accessed June 12, 2015
    • Food and Drug Administration. Savaysa–Clinical Pharmacology and Biopharmaceutics Review(s). Available at. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/206316Orig1Orig2s000ClinPharmR.pdf Accessed June 12, 2015.
    • Savaysa–Clinical Pharmacology and Biopharmaceutics Review(S)
  • 24
    • 84925493502 scopus 로고    scopus 로고
    • Laboratory measurement of the anticoagulant activity of edoxaban: A systematic review
    • Cuker A, Husseinzadeh H. Laboratory measurement of the anticoagulant activity of edoxaban: a systematic review. J Thromb Thrombol 2015; 39: 288–294.
    • (2015) J Thromb Thrombol , vol.39 , pp. 288-294
    • Cuker, A.1    Husseinzadeh, H.2
  • 25
    • 84883238313 scopus 로고    scopus 로고
    • Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran etexilate
    • Douxfils J, Dogne JM, Mullier F, et al. Comparison of calibrated dilute thrombin time and aPTT tests with LC-MS/MS for the therapeutic monitoring of patients treated with dabigatran etexilate. Thromb Haemost 2013; 110: 543–549.
    • (2013) Thromb Haemost , vol.110 , pp. 543-549
    • Douxfils, J.1    Dogne, J.M.2    Mullier, F.3
  • 26
    • 84884861345 scopus 로고    scopus 로고
    • Comparison of calibrated chromogenic anti-Xa assay and PT tests with LC-MS/MS for the therapeutic monitoring of patients treated with rivaroxaban
    • Douxfils J, Tamigniau A, Chatelain B, et al. Comparison of calibrated chromogenic anti-Xa assay and PT tests with LC-MS/MS for the therapeutic monitoring of patients treated with rivaroxaban. Thromb Haemost 2013; 110: 723–731.
    • (2013) Thromb Haemost , vol.110 , pp. 723-731
    • Douxfils, J.1    Tamigniau, A.2    Chatelain, B.3
  • 27
    • 84881605571 scopus 로고    scopus 로고
    • Performance of coagulation tests in patients on therapeutic doses of dabigatran: A cross-sectional pharmacodynamic study based on peak and trough plasma levels
    • Hawes EM, Deal AM, Funk-Adcock D, et al. Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels. J Thromb Haemost 2013; 11: 1493–1502.
    • (2013) J Thromb Haemost , vol.11 , pp. 1493-1502
    • Hawes, E.M.1    Deal, A.M.2    Funk-Adcock, D.3
  • 28
    • 84901921497 scopus 로고    scopus 로고
    • Performance of coagulation tests in patients on therapeutic doses of rivaroxaban. A cross-sectional pharmacodynamic study based on peak and trough plasma levels
    • Francart SJ, Hawes EM, Deal AM, et al. Performance of coagulation tests in patients on therapeutic doses of rivaroxaban. A cross-sectional pharmacodynamic study based on peak and trough plasma levels. Thromb Haemost 2014; 111: 1133–1140.
    • (2014) Thromb Haemost , vol.111 , pp. 1133-1140
    • Francart, S.J.1    Hawes, E.M.2    Deal, A.M.3
  • 29
    • 84914695678 scopus 로고    scopus 로고
    • Comparison of anti-xa and dilute russell viper venom time assays in quantifying drug levels in patients on therapeutic doses of rivaroxaban
    • Gosselin RC, Adcock Funk DM, Taylor JM, et al. Comparison of anti-xa and dilute russell viper venom time assays in quantifying drug levels in patients on therapeutic doses of rivaroxaban. Arch Pathol Lab Med 2014; 138: 1680–1684.
    • (2014) Arch Pathol Lab Med , vol.138 , pp. 1680-1684
    • Gosselin, R.C.1    Adcock Funk, D.M.2    Taylor, J.M.3
  • 30
    • 84869109465 scopus 로고    scopus 로고
    • Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans
    • Bathala MS, Masumoto H, Oguma T, et al. Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans. Drug Metabol Disposit 2012; 40: 2250–2255.
    • (2012) Drug Metabol Disposit , vol.40 , pp. 2250-2255
    • Bathala, M.S.1    Masumoto, H.2    Oguma, T.3
  • 31
    • 84922390215 scopus 로고    scopus 로고
    • Influence of dabigatran and rivaroxaban on routine coagulation assays. A nationwide Belgian survey
    • Van Blerk M, Bailleul E, Chatelain B, et al. Influence of dabigatran and rivaroxaban on routine coagulation assays. A nationwide Belgian survey. Thromb Haemost 2015; 113: 154–164.
    • (2015) Thromb Haemost , vol.113 , pp. 154-164
    • Van Blerk, M.1    Bailleul, E.2    Chatelain, B.3
  • 32
    • 84893185400 scopus 로고    scopus 로고
    • Assessment of apixaban plasma levels by laboratory tests: Suitability of three anti-Xa assays. A multicentre French GEHT study
    • Gouin-Thibault I, Flaujac C, Delavenne X, et al. Assessment of apixaban plasma levels by laboratory tests: suitability of three anti-Xa assays. A multicentre French GEHT study. Thromb Haemost 2014; 111: 240–248.
    • (2014) Thromb Haemost , vol.111 , pp. 240-248
    • Gouin-Thibault, I.1    Flaujac, C.2    Delavenne, X.3
  • 33
    • 84856293397 scopus 로고    scopus 로고
    • Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: Results of a multicenter field trial
    • Samama MM, Contant G, Spiro TE, et al. Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial. Clin Appl Thromb Hemost 2012; 18: 150–158.
    • (2012) Clin Appl Thromb Hemost , vol.18 , pp. 150-158
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 34
    • 84856632988 scopus 로고    scopus 로고
    • Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • Samama MM, Contant G, Spiro TE, et al. Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb Haemost 2012; 107: 379–387.
    • (2012) Thromb Haemost , vol.107 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 35
    • 84858332563 scopus 로고    scopus 로고
    • Rivaroxaban: Quantification by anti-FXa assay and influence on coagulation tests: A study in 9 Swiss laboratories
    • Asmis LM, Alberio L, Angelillo-Scherrer A, et al. Rivaroxaban: Quantification by anti-FXa assay and influence on coagulation tests: a study in 9 Swiss laboratories. Thromb Res 2012; 129: 492–498.
    • (2012) Thromb Res , vol.129 , pp. 492-498
    • Asmis, L.M.1    Alberio, L.2    Angelillo-Scherrer, A.3
  • 36
    • 84876192857 scopus 로고    scopus 로고
    • Measuring Oral Direct Inhibitors (ODIs) of thrombin and factor Xa: A recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis
    • Baglin T, Hillarp A, Tripodi A, et al. Measuring Oral Direct Inhibitors (ODIs) of thrombin and factor Xa: A recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2013; 11: 756–760.
    • (2013) J Thromb Haemost , vol.11 , pp. 756-760
    • Baglin, T.1    Hillarp, A.2    Tripodi, A.3
  • 37
    • 84928240024 scopus 로고    scopus 로고
    • Measurement of non-VKA oral anticoagulants versus classic ones: The appropriate use of hemostasis assays
    • Douxfils J, Tamigniau A, Chatelain B, et al. Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays. Thromb J 2014; 12: 24.
    • (2014) Thromb J , vol.12 , pp. 24
    • Douxfils, J.1    Tamigniau, A.2    Chatelain, B.3
  • 38
    • 49849099533 scopus 로고    scopus 로고
    • DU-176b, a potent and orally active factor Xa inhibitor: In vitro and in vivo pharmacological profiles
    • Furugohri T, Isobe K, Honda Y, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost 2008; 6: 1542–1549.
    • (2008) J Thromb Haemost , vol.6 , pp. 1542-1549
    • Furugohri, T.1    Isobe, K.2    Honda, Y.3
  • 39
    • 35048854973 scopus 로고    scopus 로고
    • Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber
    • Zafar MU, Vorchheimer DA, Gaztanaga J, et al. Antithrombotic effects of factor Xa inhibition with DU-176b: Phase-I study of an oral, direct factor Xa inhibitor using an ex-vivo flow chamber. Thromb Haemost 2007; 98: 883–888.
    • (2007) Thromb Haemost , vol.98 , pp. 883-888
    • Zafar, M.U.1    Vorchheimer, D.A.2    Gaztanaga, J.3
  • 40
    • 78649736882 scopus 로고    scopus 로고
    • Clinical laboratory measurement of direct factor Xa inhibitors: Anti-Xa assay is preferable to prothrombin time assay
    • Barrett YC, Wang Z, Frost C, et al. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost 2010; 104: 1263–1271.
    • (2010) Thromb Haemost , vol.104 , pp. 1263-1271
    • Barrett, Y.C.1    Wang, Z.2    Frost, C.3
  • 41
    • 82955195864 scopus 로고    scopus 로고
    • Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: Reduction of interassay variability
    • Harenberg J, Kramer R, Giese C, et al. Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability. J Thromb Thrombol 2011; 32: 267–271.
    • (2011) J Thromb Thrombol , vol.32 , pp. 267-271
    • Harenberg, J.1    Kramer, R.2    Giese, C.3
  • 42
    • 78149492327 scopus 로고    scopus 로고
    • An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (Rivaroxaban) in plasma
    • Samama MM, Amiral J, Guinet C, et al. An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma. Thromb Haemost 2010; 104: 1078–1079.
    • (2010) Thromb Haemost , vol.104 , pp. 1078-1079
    • Samama, M.M.1    Amiral, J.2    Guinet, C.3
  • 43
    • 84930187338 scopus 로고    scopus 로고
    • Estimation of dabigatran plasma concentrations in the perioperative setting. An ex vivo study using dedicated coagulation assays
    • Douxfils J, Lessire S, Dincq AS, et al. Estimation of dabigatran plasma concentrations in the perioperative setting. An ex vivo study using dedicated coagulation assays. Thromb Haemost 2015; 113: 862–869.
    • (2015) Thromb Haemost , vol.113 , pp. 862-869
    • Douxfils, J.1    Lessire, S.2    Dincq, A.S.3
  • 44
    • 84655163143 scopus 로고    scopus 로고
    • Optimisation of the assays for the measurement of clotting factor activity in the presence of rivaroxaban
    • Gerotziafas GT, Baccouche H, Sassi M, et al. Optimisation of the assays for the measurement of clotting factor activity in the presence of rivaroxaban. Thromb Res 2012; 129: 101–103.
    • (2012) Thromb Res , vol.129 , pp. 101-103
    • Gerotziafas, G.T.1    Baccouche, H.2    Sassi, M.3
  • 45
    • 80051595884 scopus 로고    scopus 로고
    • Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom time
    • van Os GM, de Laat B, Kamphuisen PW, et al. Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom time. J Thromb Haemost 2011; 9: 1657–1659.
    • (2011) J Thromb Haemost , vol.9 , pp. 1657-1659
    • Van Os, G.M.1    De Laat, B.2    Kamphuisen, P.W.3
  • 46
    • 59349093707 scopus 로고    scopus 로고
    • Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?
    • Robert S, Ghiotto J, Pirotte B, et al. Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs? Pharmacol Res 2009; 59: 160–166.
    • (2009) Pharmacol Res , vol.59 , pp. 160-166
    • Robert, S.1    Ghiotto, J.2    Pirotte, B.3
  • 47
    • 84925284867 scopus 로고    scopus 로고
    • Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: Comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay
    • Morishima Y, Kamisato C. Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay. Am J Clin Pathol 2015; 143: 241–247.
    • (2015) Am J Clin Pathol , vol.143 , pp. 241-247
    • Morishima, Y.1    Kamisato, C.2
  • 48
    • 84931440425 scopus 로고    scopus 로고
    • Large external quality assessment survey on thrombin generation with CAT: Further evidence for the usefulness of normalisation with an external reference plasma
    • Perrin J, Depasse F, Lecompte T, et al. Large external quality assessment survey on thrombin generation with CAT: further evidence for the usefulness of normalisation with an external reference plasma. Thromb Res 2015; 136: 125–130.
    • (2015) Thromb Res , vol.136 , pp. 125-130
    • Perrin, J.1    Depasse, F.2    Lecompte, T.3
  • 49
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: A randomised crossover ex vivo study in healthy volunteers
    • Marlu R, Hodaj E, Paris A, et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012; 108: 217–224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3
  • 50
    • 84931264466 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab
    • Honickel M, Treutler S, van Ryn J, et al. Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab. Thromb Haemost 2015; 113: 728–740.
    • (2015) Thromb Haemost , vol.113 , pp. 728-740
    • Honickel, M.1    Treutler, S.2    Van Ryn, J.3
  • 51
    • 84931291673 scopus 로고    scopus 로고
    • Reversal of anticoagulants: An overview of current developments
    • Greinacher A, Thiele T, Selleng K. Reversal of anticoagulants: an overview of current developments. Thromb Haemost 2015; 113: 931–942.
    • (2015) Thromb Haemost , vol.113 , pp. 931-942
    • Greinacher, A.1    Thiele, T.2    Selleng, K.3
  • 52
    • 84892921288 scopus 로고    scopus 로고
    • Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: Significance of studies in vitro with circulating human blood
    • Escolar G, Fernandez-Gallego V, Arellano-Rodrigo E, et al. Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: significance of studies in vitro with circulating human blood. PloS one 2013; 8: e78696.
    • (2013) Plos One , vol.8
    • Escolar, G.1    Fernandez-Gallego, V.2    Arellano-Rodrigo, E.3
  • 54
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124: 1573–1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.