GnRH agonist during luteal phase in women undergoing assisted reproductive techniques: Systematic review and meta-analysis of randomized controlled trials

Ultrasound in Obstetrics and Gynecology

Volumn 47, Issue 2, 2016, Pages 144-151

  Martins, W P ^a   Ferriani, R A ^a   Navarro, P A ^a   Nastri, C O ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

assisted reproduction; ICSI; infertility; IVF; luteal phase support; subfertility

Indexed keywords

GONADORELIN; HORMONE;

ADULT; AGONISTS; DRUG EFFECTS; FEMALE; HUMAN; INFERTILITY THERAPY; LIVE BIRTH; LUTEAL PHASE; META ANALYSIS; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK; SPONTANEOUS ABORTION; STATISTICS AND NUMERICAL DATA;

ABORTION, SPONTANEOUS; ADULT; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONES; HUMANS; LIVE BIRTH; LUTEAL PHASE; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCTIVE TECHNIQUES, ASSISTED; RISK;

EID: 84957443021     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.14874     Document Type: Article

References (35)

1. van der Linden M, Buckingham K, Farquhar C, Kremer JA, Metwally M., Luteal phase support for assisted reproduction cycles. Cochrane Database Syst Rev 2011; CD009154.
2. Fatemi HM,. The luteal phase after 3 decades of IVF: what do we know? Reprod Biomed Online 2009; 19 Suppl 4: 4331.
3. Gizzo S, Andrisani A, Esposito F, Noventa M, Di Gangi S, Angioni S, Litta P, Gangemi M, Nardelli GB,. Which luteal phase support is better for each IVF stimulation protocol to achieve the highest pregnancy rate? A superiority randomized clinical trial. Gynecol Endocrinol 2014; 30: 10.3109/09513590.2014.964638.
4. Fujii S, Sato S, Fukui A, Kimura H, Kasai G, Saito Y,. Continuous administration of gonadotrophin-releasing hormone agonist during the luteal phase in IVF. Hum Reprod 2001; 16: 1671-1675.
5. Tesarik J, Hazout A, Mendoza C,. Enhancement of embryo developmental potential by a single administration of GnRH agonist at the time of implantation. Hum Reprod 2004; 19: 1176-1180.
6. Casan EM, Raga F, Polan ML,. GnRH mRNA and protein expression in human preimplantation embryos. Mol Hum Reprod 1999; 5: 234-239.
7. Nam DH, Lee SH, Kim HS, Lee GS, Jeong YW, Kim S, Kim JH, Kang SK, Lee BC, Hwang WS,. The role of gonadotropin-releasing hormone (GnRH) and its receptor in development of porcine preimplantation embryos derived from in vitro fertilization. Theriogenology 2005; 63: 190-201.
8. Raga F, Casan EM, Kruessel J, Wen Y, Bonilla-Musoles F, Polan ML,. The role of gonadotropin-releasing hormone in murine preimplantation embryonic development. Endocrinology 1999; 140: 3705-3712.
9. Kyrou D, Kolibianakis EM, Fatemi HM, Tarlatzi TB, Devroey P, Tarlatzis BC,. Increased live birth rates with GnRH agonist addition for luteal support in ICSI/IVF cycles: a systematic review and meta-analysis. Hum Reprod Update 2011; 17: 734-740.
10. Oliveira JB, Baruffi R, Petersen CG, Mauri AL, Cavagna M, Franco JG Jr., Administration of single-dose GnRH agonist in the luteal phase in ICSI cycles: a meta-analysis. Reprod Biol Endocrinol 2010; 8: 107.
11. Gordon A, Raynes-Greenow C, McGeechan K, Morris J, Jeffery H,. Risk factors for antepartum stillbirth and the influence of maternal age in New South Wales Australia: a population based study. BMC Pregnancy Childbirth 2013; 13: 12.
12. Reddy UM, Laughon SK, Sun L, Troendle J, Willinger M, Zhang J,. Prepregnancy risk factors for antepartum stillbirth in the United States. Obstet Gynecol 2010; 116: 1119-1126.
13. Higgins J, Green S, (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011 ]. The Cochrane Collaboration, 2011. http://handbook.cochrane.org/ [Accessed March 2015]
14. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, Jaeschke R, Rind D, Meerpohl J, Dahm P, Schunemann HJ,. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 2011; 64: 383-394.
15. Ata B, Urman B., Single dose gonadotropin-releasing hormone (GnRH) agonist administration in the luteal phase of GnRH antagonist stimulated ICSI-ET cycles. ClinicalTrials.gov 2009; NCT01007851.
16. Ata B, Yakin K, Balaban B, Urman B,. GnRH agonist protocol administration in the luteal phase in ICSI-ET cycles stimulated with the long GnRH agonist protocol: a randomized, controlled double blind study. Hum Reprod 2008; 23: 668-673.
17. Isikoglu M, Ozgur K, Oehninger S,. Extension of GnRH agonist through the luteal phase to improve the outcome of intracytoplasmic sperm injection. J Reprod Med 2007; 52: 639-644.
18. Ozgur K, Isikoglu M, Seleker M,. Continuation of gonadotropin releasing hormone agonist during the luteal phase in in vitro fertilization patients: is it beneficial? Fertil Steril 2002; 78: S53.
19. Aboulghar MA, Marie H, Amin YM, Aboulghar MM, Nasr A, Serour GI, Mansour RT,. GnRH agonist plus vaginal progesterone for luteal phase support in ICSI cycles: a randomized study. Reprod Biomed Online 2015; 30: 52-56.
20. Inamdar DB, Majumdar A,. Evaluation of the impact of gonadotropin-releasing hormone agonist as an adjuvant in luteal-phase support on IVF outcome. J Hum Reprod Sci 2012; 5: 279-284.
21. Isik AZ, Caglar GS, Sozen E, Akarsu C, Tuncay G, Ozbicer T, Vicdan K,. Single-dose GnRH agonist administration in the luteal phase of GnRH antagonist cycles: a prospective randomized study. Reprod Biomed Online 2009; 19: 472-477.
22. Qublan H, Amarin Z, Al-Qudah M, Diab F, Nawasreh M, Malkawi S, Balawneh M,. Luteal phase support with GnRH-a improves implantation and pregnancy rates in IVF cycles with endometrium of ≤7 mm on day of egg retrieval. Hum Fertil 2008; 11: 43-47.
23. Razieh DF, Maryam AR, Nasim T,. Beneficial effect of luteal-phase gonadotropin-releasing hormone agonist administration on implantation rate after intracytoplasmic sperm injection. Taiwan J Obstet Gynecol 2009; 48: 245-248.
24. Tesarik J, Hazout A, Mendoza-Tesarik R, Mendoza N, Mendoza C,. Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonist- and antagonist-treated ovarian stimulation cycles. Hum Reprod 2006; 21: 2572-2579.
25. Yildiz GA, Sukur YE, Ates C, Aytac R,. The addition of gonadotrophin releasing hormone agonist to routine luteal phase support in intracytoplasmic sperm injection and embryo transfer cycles: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 2014; 182C: 66-70.
26. Zafardoust S, Jeddi-Tehrani M, Akhondi MM, Sadeghi MR, Kamali K, Mokhtar S, Badehnoosh B, Arjmand-Teymouri F, Fatemi F, Mohammadzadeh A,. Effect of administration of single dose GnRH agonist in luteal phase on outcome of ICSI-ET cycles in women with previous history of IVF/ICSI failure: A randomized controlled trial. J Reprod Infertil 2015; 16: 116-120.
27. Benmachiche A, Boularak A,. Luteal supplementation with GnRH-agonist after GnRH-agonist triggering in combination with low dose HCG in IVF. ClinicalTrials.gov 2014; NCT02053779.
28. QFS. GnRH agonist and progesterone versus progesterone only for luteal phase support in antagonist cycles (GALA). ClinicalTrials.gov 2014; NCT02262416.
29. Cengaver N., The effect of GnRH agonist administered in the luteal phase on art cycle outcomes. ClinicalTrials.gov 2014; NCT02114645.
30. Brigante CMM, Mignini Renzini M, Dal Canto M, Coticchio G, Comi R, Fadini R,. Efficacy of luteal phase support with GnRH agonists: a preliminary comparative study. Fertil Steril 2013; 100: S299.
31. Tsafrir A, Margalioth E., Luteal-phase GnRH agonist administration in frozen-thawed IVF embryo transfer cycles. ClinicalTrials.gov 2007; NCT00542126.
32. AboHamila F, Maged A, AboulFoutouh I,. Progesterone supplementation is just enough for luteal phase support in ICSI cycles. Kasr Al-Aini J Obstet Gynaecol 2011; 2: 14-19.
33. Bellver J, Labarta E, Bosch E, Melo MA, Vidal C, Remohi J, Pellicer A,. GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled trial. Fertil Steril 2010; 94: 1065-1071.
34. Loumaye E, Pirard C, Donnez J,. GnRH agonist as a novel luteal support: Results of a pilot study. Hum Reprod 2004; 19: i4.
35. Pirard C, Donnez J, Loumaye E,. GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study. Hum Reprod 2006; 21: 1894-1900.