Does the use of specialized proresolving molecules in critical care offer a more focused approach to controlling inflammation than that of fish oils?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 19, Issue 2, 2016, Pages 151-154

  Martindale, Robert G ^a   Warren, Malissa M ^a   McClave, Stephen A ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

critical care; fish oils 3 fatty acids; inflammation control; specialized proresolving molecules

Indexed keywords

ARACHIDONIC ACID; FISH OIL; OMEGA 3 FATTY ACID; ANTIINFLAMMATORY AGENT; CD59 ANTIGEN; DOCOSAHEXAENOIC ACID; LIPOXIN;

ADIPOSE TISSUE; BREAST MILK; CHEMICAL STRUCTURE; EPITHELIZATION; GENE EXPRESSION; HUMAN; INFLAMMATION; INTENSIVE CARE; LYMPH NODE; MOLECULE; NEUTROPHIL; PATHOGEN CLEARANCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SPECIALIZED PRORESOLVING MOLECULE; STEREOCHEMISTRY; SYNOVIAL FLUID; TISSUE REGENERATION; URINE; ADAPTIVE IMMUNITY; CRITICAL ILLNESS; DRUG EFFECTS; INTENSIVE CARE UNIT; PAIN; REGENERATION; WOUND HEALING;

ADAPTIVE IMMUNITY; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD59; ARACHIDONIC ACID; CRITICAL ILLNESS; DOCOSAHEXAENOIC ACIDS; FISH OILS; HUMANS; INFLAMMATION; INTENSIVE CARE UNITS; LIPOXINS; PAIN; REGENERATION; WOUND HEALING;

EID: 84957433958     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000250     Document Type: Review

References (19)

1. Calder PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochim Biophys Acta 2015; 1851:469-484.
2. Massaro M, Scoditti E, Carluccio M, et al. Omega-3 fatty acids, inflammation and angiogenesis: basic mechanisms behind the cardioprotective effects of fish and fish oils. Cell Mol Biol 2010; 56:59-82.
3. Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature 2014; 510:92-101.
4. Turner D, Shah PS, Steinhart AH, et al. Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm Bowel Dis 2011; 17:336-345.
5. Serhan CN, Krishnamoorthy S, Recchiuti, et al. Novel anti-inflammatory: proresolving mediators and their receptors. Curr Top Med Chem 2011; 11:629-647.
6. Supinski GS, Vanags J, Callahan LA. Eicosapentaenoic acid preserves diaphragm force generation following endotoxin administration. Crit Care 2010; 14:R35.
7. Headland SE, Norling LV. The resolution of inflammation: principles and challenges. Semin Immunol 2015; 27:149-160.
8. Chiang N, Fredman G, Backhed F, et al. Infection regulates proresolving mediators that lower antibiotic requirements. Nature 2012; 484:524-528.
9. Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution. Semin Immunol 2015; 27:200-215.
10. Calder PC. Functional roles of fatty acids and their effects on human health. JPEN J Parenter Enteral Nutr 2015; 39 (1 Suppl):18S-32S.
11. Chiang N, Dalli J, Colas RA, et al. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. J Exp Med 2015; 212:1203-1217.
12. Dalli J, Kraft B, Colas RA, et al. The regulation of proresolving lipid mediator profiles in baboon pneumonia by inhaled carbon monoxide. Am J Respir Cell Mol Biol 2015; 53:314-325.
13. Russell CD, Schwarze J. The role of pro-resolution lipid mediators in infectious disease. Immunology 2014; 141:166-173.
14. Baillie JK, Digard P. Influenza: time to target the host? N Engl J Med 2013; 369:191-193.
15. Morita M, Kuba K, Ichikawa A, et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 2013; 153:112-125.
16. Spite M, Norling LV, Summers L, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 2009; 461:1287-1291.
17. Finkelstein J, et al. Lipids in health and disease. Nature 2014; 510:47.
18. Colas RA, Shinohara M, Dalli J, et al. Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol 2014; 307:C39-C54.
19. Claria J, Nguyen BT, Madenci AL, et al. Diversity of lipid mediators in human adipose tissue depots. Am J Physiol Cell Physiol 2013; 304:C1141-C1149.