Development and analysis of patient-based complete conducting airways models

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Bordas, Rafel ^a   Lefevre, Christophe ^b   Veeckmans, Bart ^c   Pitt Francis, Joe ^a   Fetita, Catalin ^b   Brightling, Christopher E ^d   Kay, David ^a   Siddiqui, Salman ^d   Burrowes, Kelly S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUT MINES TELECOM   (France)

^c MATERIALISE NV   (Belgium)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AIRWAY RESISTANCE; ARTICLE; ASTHMA; BIOLOGICAL MODEL; CLINICAL ARTICLE; COMPLETE PATIENT BASED AIRWAY MODEL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW RATE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; IMAGE ANALYSIS; LUNG FUNCTION TEST; MALE; MORPHOMETRICS; PREDICTION; PROCESS DEVELOPMENT; AGED; ANATOMIC MODEL; ANATOMY AND HISTOLOGY; DIAGNOSTIC IMAGING; LUNG; MIDDLE AGED; PHYSIOLOGY; X-RAY COMPUTED TOMOGRAPHY;

AGED; AIRWAY RESISTANCE; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MODELS, ANATOMIC; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84957109037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144105     Document Type: Article

References (44)

1. Hunter P, Chapman T, Coveney PV, de Bono B, Diaz V, et al. (2013) A vision and strategy for the virtual physiological human: 2012 update. Interface focus 3: 20130004. doi: 10.1098/rsfs.2013.0004
2. De Backer JW, Vos WG, Devolder A, Verhulst SL, Germonpré P, et al. (2008) Computational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilation. Journal of Biomechanics 41: 106-113. doi: 10.1016/j.jbiomech.2007.07.009
3. Van Holsbeke CS, Leemans G, Vos WG, De Backer JW, Vinchurkar SC, et al. (2013) Functional respiratory imaging as a tool to personalize respiratory treatment in subjects with unilateral diaphragmatic paralysis. Respiratory Care: e127-31.
4. Yin Y, Choi J, Hoffman EA, Tawhai MH, Lin CL (2010) Simulation of pulmonary air flow with a subjectspecific boundary condition. Journal of Biomechanics 43: 2159-2163. doi: 10.1016/j.jbiomech.2010. 03.048
5. Weibel E (1963) Morphometry of the Human Lung. Springer. URL http://link.springer.com/book/10. 1007/978-3-642-87553-3.
6. Horsfield K, Dart G, Olson DE, Filley GF, Cumming G (1971) Models of the human bronchial tree. Journal of Applied Physiology 31: 207-217.
7. Kitaoka H, Takaki R, Suki B (1999) A three-dimensional model of the human airway tree. Journal of Applied Physiology 87: 2207-2217.
8. Howatson Tawhai M, Pullan AJ, Hunter PJ (2000) Generation of an anatomically based three-dimensional model of the conducting airways. Annals of biomedical engineering 28: 793-802. doi: 10.1114/1.1289457
9. Horsfield K, Relea FG, Cumming G (1976) Diameter, length and branching ratios in the bronchial tree. Respiration Physiology 26: 351-356. doi: 10.1016/0034-5687(76)90005-0
10. Tawhai MH, Hunter P, Tschirren J, Reinhardt J, McLennan G, et al. (2004) Ct-based geometry analysis and finite element models of the human and ovine bronchial tree. Journal of Applied Physiology 97: 2310-2321. doi: 10.1152/japplphysiol.00520.2004
11. Tawhai MH, Hunter PJ (2001) Multibreath washout analysis: modelling the influence of conducting airway asymmetry. Respiration Physiology 127: 249-258. doi: 10.1016/S0034-5687(01)00239-0
12. Swan AJ, Clark AR, Tawhai MH (2012) A computational model of the topographic distribution of ventilation in healthy human lungs. Journal of Theoretical Biology 300: 222-231. doi: 10.1016/j.jtbi.2012.01. 042
13. Tgavalekos NT, Venegas JG, Suki B, Lutchen KR (2003) Relation between structure, function, and imaging in a three-dimensional model of the lung. Annals of Biomedical Engineering 31: 363-373. doi: 10.1114/1.1557972
14. Leary D, Bhatawadekar SA, Parraga G, Maksym GN (2012) Modeling stochastic and spatial heterogeneity in a human airway tree to determine variation in respiratory system resistance. Journal of Applied Physiology 112: 167-175. doi: 10.1152/japplphysiol.00633.2011
15. Politi AZ, Donovan GM, Tawhai MH, Sanderson MJ, Lauzon AM, et al. (2010) A multiscale, spatially distributed model of asthmatic airway hyper-responsiveness. Journal of Theoretical Biology 266: 614-624. doi: 10.1016/j.jtbi.2010.07.032
16. Hedges KL, Clark AR, Tawhai MH (2015) Comparison of generic and subject-specific models for simulation of pulmonary perfusion and forced expiration. Interface Focus 5: 20140090. doi: 10.1098/rsfs. 2014.0090
17. Burrowes KS, De Backer J, Smallwood R, Sterk PJ, Gut I, et al. (2013) Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (airprom). Interface Focus 3: 20120057. doi: 10.1098/rsfs.2012.0057
18. Gonem S, Natarajan S, Desai D, Corkill S, Singapuri A, et al. (2014) Clinical significance of small airway obstruction markers in patients with asthma. Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 44: 499-507. doi: 10.1111/cea.12257
19. Gupta S, Hartley R, Khan UT, Singapuri A, Hargadon B, et al. (2014) Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients. The Journal of Allergy and Clinical Immunology 133: 729-38.e18. doi: 10.1016/j.jaci.2013.09.039
20. From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2015. Available from: http://www.ginaasthma.org
21. Schultz T, Theisel H, Seidel HP (2010) Crease surfaces: from theory to extraction and application to diffusion tensor MRI. IEEE Transactions on Visualization and Computer Graphics 16: 109-119. doi: 10. 1109/TVCG.2009.44
22. Kindlmann GL, San José Estépar R, Smith SM, Westin CF (2009) Sampling and visualizing creases with scale-space particles. IEEE Transactions on Visualization and Computer Graphics 15: 1415-1424. doi: 10.1109/TVCG.2009.177
23. Fetita CI, Prêteux F, Beigelman-Aubry C, Grenier P (2004) Pulmonary airways: 3-d reconstruction from multislice CT and clinical investigation. IEEE Transactions on Medical Imaging 23: 1353-1364. doi: 10. 1109/TMI.2004.840453
24. Fetita C, Ortner M, Brillet PY, Preteux F, Grenier P, et al. (2009) A morphological-Aggregative approach for 3d segmentation of pulmonary airways from generic msct acquisitions. In: Proc. of Second International Workshop on Pulmonary Image Analysis. pp. 215-226.
25. Fetita C, Ortner M, Brillet PY, Ould Hmeidi Y, Prêteux F (2010) Airway shape assessment with visual feed-back in asthma and obstructive diseases. In: Proc. of SPIE, volume 7625, pp. 76251E-76251E-12. doi: 10.1117/12.844445
26. Serra J (1983) Image Analysis and Mathematical Morphology. Orlando, FL, USA: Academic Press, Inc.
27. Haefeli-Bleuer B, Weibel ER (1988) Morphometry of the human pulmonary acinus. The Anatomical Record 220: 401-414. doi: 10.1002/ar.1092200410
28. Pedley TJ, Schroter RC, Sudlow MF (1970) Energy losses and pressure drop in models of human airways. Respiration Physiology 9: 371-386. doi: 10.1016/0034-5687(70)90093-9
29. Wongviriyawong C, Harris RS, Zheng H, Kone M, Winkler T, et al. (2012) Functional effect of longitudinal heterogeneity in constricted airways before and after lung expansion. Journal of Applied Physiology 112: 237-245. doi: 10.1152/japplphysiol.01400.2010
30. Ismail M, Comerford A, Wall WA (2013) Coupled and reduced dimensional modeling of respiratory mechanics during spontaneous breathing. International Journal for Numerical Methods in Biomedical Engineering 29: 1285-1305. doi: 10.1002/cnm.2577
31. Kim M, Bordas R, Vos W, Hartley RA, Brightling CE, et al. (2015) Dynamic flow characteristics in normal and asthmatic lungs. International Journal for Numerical Methods in Biomedical Engineering: In Press.
32. Choi J (2011) Multiscale numerical analysis of airflow in CT based subject specific breathing in human lungs (Chapter 7). Ph.D.Thesis, University of Iowa, Graduate College, The University of Iowa, Iowa City, Iowa, USA. Http://ir.uiowa.edu/etd/2685.
33. Hyatt RE, Wilcon RE (1963) The pressure-flow relationships of the intrathoracic airway in man. Journal of Clinical Investigation 42: 29-39. doi: 10.1172/JCI104693
34. Steiger JH (1980) Tests for comparing elements of a correlation matrix. Psychological Bulletin 87: 245-251. doi: 10.1037/0033-2909.87.2.245
35. Pedley TJ, Schroter RC, Sudlow MF (1970) The prediction of pressure drop and variation of resistance within the human bronchial airways. Respiration physiology 9: 387-405. doi: 10.1016/0034-5687(70) 90094-0
36. Tgavalekos NT, Tawhai M, Harris RS, Mush G, Vidal-Melo M, et al. (2005) Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: An image functional modeling approach. Journal of Applied Physiology 99: 2388-2397. doi: 10.1152/japplphysiol.00391.2005
37. Campana L, Kenyon J, Zhalehdoust-Sani S, Tzeng YS, Sun Y, et al. (2009) Probing airway conditions governing ventilation defects in asthma via hyperpolarized mri image functional modeling. Journal of Applied Physiology 106: 1293-1300. doi: 10.1152/japplphysiol.91428.2008
38. Montaudon M, Lederlin M, Reich S, Begueret H, Tunon-de Lara JM, et al. (2009) Bronchial measurements in patients with asthma: Comparison of quantitative thin-section CT findings with those in healthy subjects and correlation with pathologic findings. Radiology 253: 844-853. doi: 10.1148/radiol. 2533090303
39. De Backer JW, Vos WG, Vinchurkar SC, Claes R, Drollmann A, et al. (2010) Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology 257: 854-862. doi: 10. 1148/radiol.10100322
40. Gillis HL, Lutchen KR (1999) How heterogeneous bronchoconstriction affects ventilation distribution in human lungs: A morphometric model. Annals of Biomedical Engineering 27: 14-22. doi: 10.1114/1.161
41. Leary D, Winkler T, Braune A, Maksym GN (2014) Effects of airway tree asymmetry on the emergence and spatial persistence of ventilation defects. Journal of Appled Physiology (1985) 117: 353-362. doi: 10.1152/japplphysiol.00881.2013
42. Lutchen KR, Gillis H (1997) Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance. Journal of Applied Physiology 83: 1192-1201.
43. Lutchen KR, Jensen A, Atileh H, Kaczka DW, Israel E, et al. (2001) Airway constriction pattern is a central component of asthma severity: The role of deep inspirations. American Journal of Respiratory and Critical Care Medicine 164: 207-215. doi: 10.1164/ajrccm.164.2.2008119
44. Ma B, Lutchen KR (2006) An anatomically based hybrid computational model of the human lung and its application to low frequency oscillatory mechanics. Annals of Biomedical Engineering 34: 1691-1704. doi: 10.1007/s10439-006-9184-7