Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis

Journal of the American Medical Directors Association

Volumn 17, Issue 6, 2016, Pages 482-490

  Beauchet, Olivier ^a,b,c,m   Annweiler, Cédric ^d   Callisaya, Michele L ^e,f   De Cock, Anne Marie ^g,n   Helbostad, Jorunn L ^h   Kressig, Reto W ^i,o   Srikanth, Velandai ^f   Steinmetz, Jean Paul ^j   Blumen, Helena M ^k   Verghese, Joe ^k   Allali, Gilles ^k,l  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c Center of Excellence on Aging and Chronic Diseases of McGill Integrated University Health Network   (Canada)

^d ANGERS UNIVERSITY HOSPITAL   (France)

^e UNIVERSITY OF TASMANIA   (Australia)

^f MONASH UNIVERSITY   (Australia)

^g UNIVERSITY OF ANTWERP   (Belgium)

^h NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

ⁱ Felix Platter Spital   (Switzerland)

^j Michel Rodange Luxembourg   (Luxembourg)

^k ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^l GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^m MCGILL UNIVERSITY   (Canada)

ⁿ AZ St Maarten Mechelen   (Belgium)

^o UNIVERSITY OF BASEL   (Switzerland)

more..

Author keywords

Dementia; Epidemiology; Gait disorders ataxia; Motor control

Indexed keywords

ALZHEIMER DISEASE; ATAXIA; DEMENTIA; DIFFUSE LEWY BODY DISEASE; FRONTOTEMPORAL DEMENTIA; GAIT; GAIT APRAXIA; GAIT DISORDER; HUMAN; MOTOR NEURON DISEASE; MULTIINFARCT DEMENTIA; NEUROLOGIC GAIT DISORDER; PREDICTIVE VALUE; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; WALKING; AGED; FEMALE; MALE; META ANALYSIS; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DEMENTIA; FEMALE; GAIT; HUMANS; MALE; PREDICTIVE VALUE OF TESTS; PSYCHOMOTOR PERFORMANCE;

EID: 84957096800     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2015.12.092     Document Type: Review

References (45)

1. Verghese J., Lipton R.B., Hall C.B., et al. Abnormality of gait as a predictor of non-Alzheimer's dementia. N Engl J Med 2002, 347:1761-1768.
2. Alexander N.B. Gait disorders in older adults. J Am Geriatr Soc 1996, 44:434-451.
3. Odenheimer G., Funkenstein H.H., Beckett L., et al. Comparison of neurologic changes in 'successfully aging' persons vs the total aging population. Arch Neurol 1994, 51:573-580.
4. Nutt J.G. Classification of gait and balance disorders. Adv Neurol 2001, 87:135-141.
5. Montero-Odasso M., Verghese J., Beauchet O., Hausdorff J.M. Gait and cognition: A complementary approach to understanding brain function and the risk of falling. J Am Geriatr Soc 2012, 60:2127-2136.
6. Seidler R.D., Bernard J.A., Burutolu T.B., et al. Motor control and aging: Links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev 2010, 34:721-733.
7. Beauchet O., Allali G., Montero-Odasso M., et al. Motor phenotype of decline in cognitive performance among community-dwellers without dementia: Population-based study and meta-analysis. PLoS One 2014, 9:e99318.
8. Dubois B., Feldman H.H., Jacova C., et al. Advancing research diagnostic criteria for Alzheimer's disease: The IWG-2 criteria. Lancet Neurol 2014, 13:614-629.
9. Morris J.C., Blennow K., Froelich L., et al. Harmonized diagnostic criteria for Alzheimer's disease: Recommendations. J Intern Med 2014, 275:204-213.
10. Cummings J.L., Dubois B., Molinuevo J.L., Scheltens P. International Work Group criteria for the diagnosis of Alzheimer disease. Med Clin North Am 2013, 97:363-368.
11. Anand R., Gill K.D., Mahdi A.A. Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology 2014, 76:27-50.
12. Handels R.L., Joore M.A., Tran-Duy A., et al. Early cost-utility analysis of general and cerebrospinal fluid-specific Alzheimer's disease biomarkers for hypothetical disease-modifying treatment decision in mild cognitive impairment. Alzheimers Dement 2015, 11:896-905.
13. Matthews F.E., Arthur A., Barnes L.E., et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: Results of the Cognitive Function and Ageing Study I and II. Lancet 2013, 382:1405-1412. Medical Research Council Cognitive Function and Ageing Collaboration.
14. Prince M., Bryce R., Albanese E., et al. The global prevalence of dementia: A systematic review and meta-analysis. Alzheimers Dement 2013, 9:63-75.
15. Verghese J., Wang C., Lipton R.B., Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 2013, 68:412-418.
16. Verghese J., Annweiler C., Ayers E., et al. Motoric cognitive risk syndrome: Multicountry prevalence and dementia risk. Neurology 2014, 83:718-726.
17. Alves G., Larsen J.P., Emre M., et al. Changes in motor subtype and risk for incident dementia in Parkinson's disease. Mov Disord 2006, 21:1123-1130.
18. Abbott R.D., White L.R., Ross G.W., et al. Walking and dementia in physically capable elderly men. JAMA 2004, 292:1447-1453.
19. Abellan van Kan G., Rolland Y., Gillette-Guyonnet S., et al. Gait speed, body composition, and dementia. The EPIDOS-Toulouse cohort. J Gerontol A Biol Sci Med Sci 2012, 67:425-432.
20. Aggarwal N.T., Wilson R.S., Beck T.L., et al. Motor dysfunction in mild cognitive impairment and the risk of incident Alzheimer disease. Arch Neurol 2006, 63:1763-1769.
21. Ramakers I.H., Visser P.J., Aalten P., et al. Symptoms of preclinical dementia in general practice up to five years before dementia diagnosis. Dement Geriatr Cogn Disord 2007, 24:300-306.
22. Verghese J., Wang C., Lipton R.B., et al. Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 2007, 78:929-935.
23. Verghese J., Derby C., Katz M.J., Lipton R.B. High risk neurological gait syndrome and vascular dementia. J Neural Transm 2007, 114:1249-1252.
24. Waite L.M., Grayson D.A., Piguet O., et al. Gait slowing as a predictor of incident dementia: 6-year longitudinal data from the Sydney Older Persons Study. J Neurol Sci 2005, 229-230:89-93.
25. Wang L., Larson E.B., Bowen J.D., van Belle G. Performance-based physical function and future dementia in older people. Arch Intern Med 2006, 166:1115-1120.
26. von Elm E., Altman D.G., Egger M., et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol 2008, 61:344-349.
27. Liberati A., Altman D.G., Tetzlaff J., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. J Clin Epidemiol 2009, 62:e1-e34.
28. Wells G, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2013. Available at: . Accessed March 25, 2015. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
29. Buchman A.S., Leurgans S.E., Boyle P.A., et al. Combinations of motor measures more strongly predict adverse health outcomes in old age: The rush memory and aging project, a community-based cohort study. BMC Med 2011, 9:42.
30. Tolea M.I., Morris J.C., Galvin J.E. Trajectory of mobility decline by type of dementia. Alzheimer Dis Assoc Disord 2015, [Epub ahead of print].
31. Tolea M.I., Morris J.C., Galvin J.E. Longitudinal associations between physical and cognitive performance among community-dwelling older adults. PLoS One 2015, 10:e0122878.
32. Buracchio T., Dodge H.H., Howieson D., et al. The trajectory of gait speed preceding mild cognitive impairment. Arch Neurol 2010, 67:980-986.
33. Camicioli R., Howieson D., Oken B., et al. Motor slowing precedes cognitive impairment in the oldest old. Neurology 1998, 50:1496-1498.
34. Marquis S., Moore M.M., Howieson D.B., et al. Independent predictors of cognitive decline in healthy elderly persons. Arch Neurol 2002, 59:601-606.
35. Mielke M.M., Roberts R.O., Savica R., et al. Assessing the temporal relationship between cognition and gait: Slow gait predicts cognitive decline in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci 2013, 68:929-937.
36. Abramson J.H. WINPEPI updated: Computer programs for epidemiologists, and their teaching potential. Epidemiol Perspect Innov 2011, 8:1.
37. Higgins J.P., Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 2002, 21:1539-1558.
38. Allali G., Annweiler C., Blumen H.M., et al. Gait phenotype from mild cognitive impairment to moderate dementia: Results from the GOOD initiative. Eur J Neurol 2015, [Epub ahead of print].
39. Beauchet O., Annweiler C., Verghese J., et al. Biology of gait control: Vitamin D involvement. Neurology 2011, 76:1617-1622.
40. Ble A., Volpato S., Zuliani G., et al. Executive function correlates with walking speed in older persons: The InCHIANTI study. J Am Geriatr Soc 2005, 53:410-415.
41. Hausdorff J.M., Yogev G., Springer S., et al. Walking is more like catching than tapping: Gait in the elderly as a complex cognitive task. Exp Brain Res 2005, 164:541-548.
42. Beauchet O., Annweiler C., Montero-Odasso M., et al. Gait control: A specific subdomain of executive function?. J Neuroeng Rehabil 2012, 9:12.
43. Rosso A.L., Olson Hunt M.J., Yang M., et al. Higher step length variability indicates lower gray matter integrity of selected regions in older adults. Gait Posture 2014, 40:225-230. Health ABC study.
44. Rosano C., Sigurdsson S., Siggeirsdottir K., et al. Magnetization transfer imaging, white matter hyperintensities, brain atrophy and slower gait in older men and women. Neurobiol Aging 2010, 31:1197-1204.
45. Rosano C., Brach J., Studenski S., et al. Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults. Neuroepidemiology 2007, 29:193-200.