Jumonji histone demethylases as emerging therapeutic targets

Pharmacological Research

Volumn 105, Issue , 2016, Pages 146-151

  Park, Sung Yeon ^a   Park, Jong Wan ^a   Chun, Yang Sook ^a  

^a Seoul National University   (South Korea)

Author keywords

Cancer; Epigenetic regulator; Jumonji histone demethylases; p53

Indexed keywords

HISTONE DEMETHYLASE; PROTEIN KDM7C; PROTEIN P53; TUMOR MARKER; UNCLASSIFIED DRUG;

CANCER CELL; CANCER PROGNOSIS; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME SUBSTRATE; EPIGENETICS; GENE TARGETING; HUMAN; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; UPREGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; MOLECULARLY TARGETED THERAPY; NEOPLASMS;

ANIMALS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MOLECULAR TARGETED THERAPY; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84956777067     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.01.026     Document Type: Review

References (85)

1. S.L. Berger The complex language of chromatin regulation during transcription Nature 447 2007 407 412
2. T. Kouzarides Chromatin modifications and their function Cell 128 4 2007 693 705
3. K. Fortschegger, and R. Shiekhattar Plant homeodomain fingers form a helping hand for transcription Epigenetics 6 1 2011 4 8
4. S. Krishnan, S. Horowitz, and R.C. Trievel Structure and function of histone H3 lysine 9 methyltransferases and demethylases ChemBioChem 12 2 2011 254 263
5. C.H. Arrowsmith, C. Bountra, P.V. Fish, and et al. Epigenetic protein families: a new frontier for drug discovery Nat. Rev. Drug Discov. 11 5 2012 384 400
6. R.J. Klose, E.M. Kallin, and Y. Zhang JmjC-domain-containing proteins and histone demethylation Nat. Rev. Genet. 7 9 2006 715 727
7. M.T. Pedersen, and K. Helin Histone demethylases in development and disease Trends Cell Biol. 20 11 2010 662 671
8. J.W. Højfeldt, K. Agger, and K. Helin Histone lysine demethylases as targets for anticancer therapy Nat. Rev. Drug Discov. 12 12 2013 917 930
9. A. Shmakova, M. Batie, J. Druker, and S. Rocha Chromatin and oxygen sensing in the context of JmjC histone demethylases Biochem. J. 462 3 2014 385 395
10. F. Crea, L. Sun, A. Mai, and et al. The emerging role of histone lysine demethylases in prostate cancer Mol. Cancer 11 2012 52
11. K.W. Wagner, H. Alam, S.S. Dhar, and et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling J. Clin. Invest. 123 12 2013 5231 5246
12. H. Liu, L. Liu, A. Holowatyj, and et al. Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer Mol. Carcinog. 2015 10.1002/mc.22341 [Epub ahead of print]
13. Y. Huang, Y. Liu, L. Yu, and et al. Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer Tum. Biol. 36 1 2015 271 278
14. D. Frescas, D. Guardavaccaro, S.M. Kuchay, and et al. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state Cell Cycle 7 22 2008 3539 3547
15. D. Frescas, D. Guardavaccaro, F. Bassermann, and et al. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes Nature 450 7167 2007 309 313
16. J. He, A.T. Nguyen, and Y. Zhang KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia Blood 117 14 2011 3869 3880
17. A. Tzatsos, P. Paskaleva, F. Ferrari, and et al. KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs J. Clin. Invest. 123 2 2013 727 739
18. F. Kottakis, C. Polytarchou, P. Foltopoulou, and et al. FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway Mol. Cell 43 2 2011 285 298
19. M.A. Wade, D. Jones, L. Wilson, and et al. The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer Nucl. Acids Res. 43 1 2015 196 207
20. J. Qi, K. Nakayama, R.D. Cardiff, and et al. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors Cancer Cell 18 1 2010 23 38
21. M. Uemura, H. Yamamoto, I. Takemasa, and et al. Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells Clin. Cancer Res. 16 18 2010 4636 4646
22. X. Guo, M. Shi, L. Sun, and et al. The expression of histone demethylase JMJD1A in renal cell carcinoma Neoplasma 58 2 2011 153 157
23. D. Yamada, S. Kobayashi, H. Yamamoto, and et al. Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection Ann. Surg. Oncol. 19 Suppl. 3 2012 S355 S364
24. E.C. Kauffman, B.D. Robinson, M.J. Downes, and et al. Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer Mol. Carcinog. 50 12 2011 931 944
25. Q. Ye, A. Holowatyj, J. Wu, and et al. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer Am. J. Cancer Res. 5 4 2015 1519 1530
26. J.G. Pryor, B.A. Brown-Kipphut, A. Iqbal, and G.A. Scott Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor Am. J. Dermatopathol. 33 8 2011 780 785
27. G. Liu, A. Bollig-Fischer, B. Kreike, and et al. Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer Oncogene 28 50 2009 4491 4500
28. K. Uimonen, H. Merikallio, P. Pääkkö, and et al. GASC1 expression in lung carcinoma is associated with smoking and prognosis of squamous cell carcinoma Histol. Histopathol. 29 6 2014 797 804
29. Z.Q. Yang, I. Imoto, Y. Fukuda, and et al. Identification of a novel gene, GASC1, within an amplicon at 9p 23-24 frequently detected in esophageal cancer cell lines Cancer Res. 60 17 2000 4735 4739
30. L.L. Sun, J.Y. Wu, Z.Y. Wu, and et al. A three-gene signature and clinical outcome in esophageal squamous cell carcinoma Int. J. Cancer 136 6 2015 E569 577
31. Y. Ozaki, K. Fujiwara, M. Ikeda, and et al. The oncogenic role of GASC1 in chemically induced mouse skin cancer Mamm. Genome. 26 11-12 2015 591 597
32. H.E. Suikki, P.M. Kujala, T.L. Tammela, and et al. Genetic alterations and changes in expression of histone demethylases in prostate cancer Prostate 70 8 2010 889 898
33. U. Vinatzer, M. Gollinger, L. Müllauer, and et al. Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3, Clin Cancer Res. 14 20 2008 6426 6431
34. A. Ehrbrecht, U. Müller, M. Wolter, and et al. Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components J. Pathol. 208 4 2006 554 563
35. Y.C. Teng, C.F. Lee, Y.S. Li, and et al. Histone demethylase RBP2 promotes lung tumorigenesis and cancer metastasis Cancer Res. 73 15 2013 4711 4721
36. G.G. Wang, J. Song, Z. Wang, and et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger Nature 459 7248 2009 847 851
37. T. Vogt, M. Kroiss, M. McClelland, and et al. Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer Lab. Invest. 79 12 1999 1615 1627
38. A. Roesch, B. Becker, S. Meyer, and et al. Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas Mod. Pathol. 18 9 2005 1249 1257
39. S. Yamamoto, Z. Wu, H.G. Russnes, and et al. JARID1B is a luminal lineage-driving oncogene in breast cancer Cancer Cell 25 6 2014 762 777
40. Y. Xiang, Z. Zhu, G. Han, and et al. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer Proc. Natl. Acad. Sci. U. S. A. 104 49 2007 19226 19231
41. S. Hayami, M. Yoshimatsu, A. Veerakumarasivam, and et al. Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway Mol. Cancer 9 2010 59
42. J. Stein, M. Majores, M. Rohde, and et al. KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy Am. J. Pathol. 184 9 2014 2430 2437
43. Z. Jangravi, M.S. Tabar, M. Mirzaei, and et al. Two splice variants of Y chromosome-located lysine-specific demethylase 5D have distinct function in prostate cancer cell line (DU-145) J. Proteome Res. 14 9 2015 3492 3502
44. G.L. Dalgliesh, K. Furge, C. Greenman, and et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 7279 2010 360 363
45. J. Liu, W. Lee, Z. Jiang, and et al. Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events Genome Res. 22 12 2012 2315 2327
46. E. Nakata, Y. Yukimachi, H. Kariyazono, and et al. Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging Bioorg. Med. Chem. 17 19 2009 6952 6958
47. G. van Haaften, G.L. Dalgliesh, H. Davies, and et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat. Genet. 41 5 2009 521 523
48. I. Ibragimova, M.E. Maradeo, E. Dulaimi, and P. Cairns Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC Epigenetics 8 5 2013 486 493
49. E.M. Smith, K. Boyd, and F.E. Davies The potential role of epigenetic therapy in multiple myeloma Br. J. Haematol. 148 5 2010 702 713
50. Y. Gui, G. Guo, Y. Huang, and et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder Nat. Genet. 43 9 2011 875 878
51. P. Ntziachristos, A. Tsirigos, G.G. Welstead, and et al. Contrasting roles of histone 3 lysine 27 demethylases in acutelymphoblastic leukaemia Nature 514 7523 2014 513 517
52. J.H. Kim, A. Sharma, S.S. Dhar, and et al. UTX and MLL4 coordinately regulate transcriptional programs for cellproliferation and invasiveness in breast cancer cells Cancer Res. 74 6 2014 1705 1717
53. J. Ma, N. Wang, Y. Zhang, and et al. KDM6B Elicits cell apoptosis by promoting nuclear translocation of FOXO1 in non-small cell lung cancer Cell. Physiol. Biochem. 37 1 2015 201 213
54. P.P. Zhang, X.L. Wang, W. Zhao, and et al. DNA methylation-mediated repression of miR-941 enhances lysine (K)-specific demethylase 6B expression in hepatoma cells J. Biol. Chem. 289 35 2014 24724 24735
55. T.Y. Lin, Y.C. Cheng, H.C. Yang, and et al. Loss of the candidate tumor suppressor BTG3 triggers acute cellularsenescence via the ERK-JMJD3-p16 (INK4a) signaling axis Oncogene 31 27 2012 3287 3297
56. K. Komiya, N. Sueoka-Aragane, A. Sato, and et al. Expression of Mina53, a novel c-Myc target gene, is a favorableprognostic marker in early stage lung cancer Lung Cancer 69 2 2010 232 238
57. C. Suzuki, K. Takahashi, S. Hayama, and et al. Identification of Myc-associated protein with JmjC domain as a noveltherapeutic target oncogene for lung cancer Mol. Cancer Ther. 6 2 2007 542 551
58. F. Abidi, M. Miano, J. Murray, and C. Schwartz A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate Clin. Genet. 72 1 2007 19 22
59. C. Loenarz, W. Ge, M.L. Coleman, and et al. PHF8, a gene associated with cleft lip/palate and mental retardation,codes for an Nepsilon-dimethyl lysine demethylase Hum. Mol. Genet. 19 2 2010 217 222
60. D. Kleine-Kohlbrecher, J. Christensen, J. Vandamme, and et al. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation Mol. Cell 38 2 2010 165 178
61. C. Redin, B. Gerard, J. Lauer, and et al. Efficient strategy for the molecular diagnosis of intellectual disability using targeted high-throughput sequencing J. Med. Genet. 51 11 2014 724 736
62. H.H. Qi, M. Sarkissian, G.Q. Hu, and et al. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain andcraniofacial development Nature 466 7305 2010 503 507
63. G. Zhu, L. Liu, L. She, and et al. Elevated expression of histone demethylase PHF8 associates with adverseprognosis in patients of laryngeal and hypopharyngeal squamous cell carcinoma Epigenomics 7 2 2015 143 153
64. X. Sun, J.J. Qiu, S. Zhu, and et al. Oncogenic features of PHF8 histone demethylase in esophageal squamous cell carcinoma PLoS One 8 10 2013 77353
65. Y. Shen, X. Pan, and H. Zhao The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer Biochem. Biophys. Res. Commun. 451 1 2014 119 125
66. Q. Ma, Z. Chen, G. Jia, and et al. The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b Onco. Targets Ther. 8 2015 1979 1988
67. C. Huang, Y. Xiang, Y. Wang, and et al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4 Cell Res. 20 2 2010 154 165
68. A. Baba, F. Ohtake, Y. Okuno, and et al. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B Nat. Cell Biol. 13 6 2011 668 675
69. K. Hata, R. Takashima, K. Amano, and et al. Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes Nat. Commun. 4 2013 2850
70. H.J. Kim, J.W. Park, K.H. Lee, and et al. Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation Cell Res. 24 10 2014 1231 1249
71. Y. Okuno, F. Ohtake, K. Igarashi, and et al. Epigenetic regulation of adipogenesis by PHF2 histone demethylase Diabetes 62 5 2013 1426 1434
72. K.H. Lee, U.I. Ju, J.Y. Song, and Y.S. Chun The histone demethylase PHF2 promotes fat cell differentiation as an epigenetic activator of both C/EBPα and C/EBPδ Mol. Cells 37 10 2014 734 741
73. J.D. Stender, G. Pascual, W. Liu, and et al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20 Mol. Cell 48 1 2012 28 38
74. L.L. Sun, X.X. Sun, X.E. Xu, and et al. Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma Acta Histochem. 115 1 2013 56 62
75. S. Sinha, R.K. Singh, N. Alam, and et al. Alterations in candidate genes PHF2 FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma Mol. Cancer 7 2008 84
76. K.H. Lee, J.W. Park, H.S. Sung, and et al. PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer Oncogene 34 22 2015 2897 2909
77. A. Ghosh, S. Ghosh, G.P. Maiti, and et al. Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck Ann. Surg. Oncol. 19 Suppl. 3 2012 S528 S538
78. A. Ghosh, G.P. Maiti, M.N. Bandopadhyay, and et al. Inactivation of 9q22.3 tumor suppressor genes predict outcome for patients with head and neck squamous cell carcinoma Anticancer Res. 33 3 2013 1215 1220
79. G.L. Wiesner, D. Daley, S. Lewis, and et al. A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22. 2-31.2 Proc. Natl. Acad. Sci. U. S. A. 100 22 2003 12961 12965
80. A.J. Levine, and M. Oren The first 30 years of p53: growing ever more complex Nat. Rev. Cancer 9 10 2009 749 758
81. T. Riley, E. Sontag, P. Chen, and A. Levine Transcriptional control of human p53-regulated genes Nat. Rev. Mol. Cell Biol. 9 5 2008 402 412
82. S. Chuikov, J.K. Kurashi, J.R. Wilson, and et al. Regulation of p53 activity through lysine methylation Nature 432 7015 2004 353 360
83. X. Shi, I. Kachirskaia, H. Yamaguchi, and et al. Modulation of p53 function by SET8-mediated methylation at lysine 382 Mol. Cell 27 4 2007 636 646
84. J. Huang, L. Perez-Burgos, B.J. Placek, and et al. Repression of p53 activity by Smyd2-mediated methylation Nature 444 7119 2006 629 632
85. S.K. Mungamuri, E.K. Benson, S. Wang, and et al. p53-mediated heterochromatin reorganization regulates its cell fate decisions Nat. Struct. Mol. Biol. 19 5 2012 478 484 S1