Antiviral activity of SA-2 against influenza A virus in vitro/vivo and its inhibition of RNA polymerase

Antiviral Research

Volumn 127, Issue , 2016, Pages 68-78

  Yu, Jie ^a   Wang, Dechuan ^a   Jin, Jing ^a   Xu, Jun ^a   Li, Mengwei ^a   Wang, Hui ^a   Dou, Jie ^a   Zhou, Changlin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiviral activity; Benzoic acid derivatives; Influenza A virus; Oseltamivir resistant; RNA polymerase inhibition

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ANTIVIRUS AGENT; BENZOIC ACID DERIVATIVE; ETHYL 4 (2 HYDROXYMETHYL 5 OXOPYRROLIDIN 1 YL) 3 [3 (3 METHYLBENZOYL)THIOUREIDO]BENZOATE; OSELTAMIVIR; RIBAVIRIN; RNA POLYMERASE; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CC50; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; EC50; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A; INFLUENZA A VIRUS; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H3N2); MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS ENTRY; VIRUS RELEASE; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; A-549 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIVIRAL RESISTANCE; BIOSYNTHESIS; CHEMISTRY; DOG; DRUG EFFECTS; HEK293 CELL LINE; INFLUENZA, HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; MDCK CELL LINE; ORTHOMYXOVIRIDAE INFECTIONS; PRECLINICAL STUDY; VIROLOGY;

A549 CELLS; ACUTE LUNG INJURY; ANIMALS; ANTIVIRAL AGENTS; BENZOATES; DNA-DIRECTED RNA POLYMERASES; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, VIRAL; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA, HUMAN; MADIN DARBY CANINE KIDNEY CELLS; MALE; MICE; MICE, INBRED ICR; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; RIBAVIRIN; VIRUS REPLICATION;

EID: 84956774237     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2016.01.011     Document Type: Article

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