메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN P 15095; IL15RA PROTEIN, MOUSE; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR;

EID: 84956647693     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19699     Document Type: Article
Times cited : (17)

References (48)
  • 1
    • 0034610970 scopus 로고    scopus 로고
    • Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    • Kennedy, M. K. et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191, 771-780 (2000).
    • (2000) J Exp Med , vol.191 , pp. 771-780
    • Kennedy, M.K.1
  • 2
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • Lucas, M., Schachterle, W., Oberle, K., Aichele, P., Diefenbach, A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26, 503-517 (2007).
    • (2007) Immunity , vol.26 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 3
    • 83755178604 scopus 로고    scopus 로고
    • IL-15 regulates homeostasis and terminal maturation of NKT cells
    • Gordy, L. E. et al. IL-15 regulates homeostasis and terminal maturation of NKT cells. J Immunol 187, 6335-6345 (2011).
    • (2011) J Immunol , vol.187 , pp. 6335-6345
    • Gordy, L.E.1
  • 4
    • 41149176392 scopus 로고    scopus 로고
    • Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation
    • Zhang, C., Zhang, J., Niu, J., Zhang, J., Tian, Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine 42, 128-136 (2008).
    • (2008) Cytokine , vol.42 , pp. 128-136
    • Zhang, C.1    Zhang, J.2    Niu, J.3    Zhang, J.4    Tian, Z.5
  • 5
    • 0028221433 scopus 로고
    • Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
    • Giri, J. G. et al. Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. The EMBO journal 13, 2822-2830 (1994).
    • (1994) The EMBO Journal , vol.13 , pp. 2822-2830
    • Giri, J.G.1
  • 6
    • 0029099146 scopus 로고
    • Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
    • Giri, J. G. et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. The EMBO journal 14, 3654-3663 (1995).
    • (1995) The EMBO Journal , vol.14 , pp. 3654-3663
    • Giri, J.G.1
  • 7
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann, T. A., Tagaya, Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17, 19-49 (1999).
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 8
    • 84864983867 scopus 로고    scopus 로고
    • Regulating the immune system via IL-15 transpresentation
    • Castillo, E. F., Schluns, K. S. Regulating the immune system via IL-15 transpresentation. Cytokine 59, 479-490 (2012).
    • (2012) Cytokine , vol.59 , pp. 479-490
    • Castillo, E.F.1    Schluns, K.S.2
  • 9
    • 47949104013 scopus 로고    scopus 로고
    • How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: Lessons from interleukin-15 (IL-15)/IL-15 receptor alpha
    • Duitman, E. H., Orinska, Z., Bulanova, E., Paus, R., Bulfone-Paus, S. How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol 28, 4851-4861 (2008).
    • (2008) Mol Cell Biol , vol.28 , pp. 4851-4861
    • Duitman, E.H.1    Orinska, Z.2    Bulanova, E.3    Paus, R.4    Bulfone-Paus, S.5
  • 10
    • 43549096677 scopus 로고    scopus 로고
    • IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    • Mortier, E., Woo, T., Advincula, R., Gozalo, S., Ma, A. IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 205, 1213-1225 (2008).
    • (2008) J Exp Med , vol.205 , pp. 1213-1225
    • Mortier, E.1    Woo, T.2    Advincula, R.3    Gozalo, S.4    Ma, A.5
  • 11
    • 84863562572 scopus 로고    scopus 로고
    • Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum
    • Bergamaschi, C. et al. Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum. Blood 120, e1-8 (2012).
    • (2012) Blood , vol.120 , pp. e1-8
    • Bergamaschi, C.1
  • 12
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Ralpha recycles and presents IL-15 in trans to neighboring cells
    • Dubois, S., Mariner, J., Waldmann, T. A., Tagaya, Y. IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17, 537-547 (2002).
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 13
    • 84902124164 scopus 로고    scopus 로고
    • IL-15.IL-15Ralpha complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells
    • Tamzalit, F. et al. IL-15.IL-15Ralpha complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells. Proc Natl Acad Sci USA 111, 8565-8570 (2014).
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 8565-8570
    • Tamzalit, F.1
  • 14
    • 33750335080 scopus 로고    scopus 로고
    • Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    • Stoklasek, T. A., Schluns, K. S., Lefrancois, L. Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol 177, 6072-6080 (2006).
    • (2006) J Immunol , vol.177 , pp. 6072-6080
    • Stoklasek, T.A.1    Schluns, K.S.2    Lefrancois, L.3
  • 15
    • 34247155347 scopus 로고    scopus 로고
    • Emerging cytokine targets in rheumatoid arthritis
    • Asquith, D. L., McInnes, I. B. Emerging cytokine targets in rheumatoid arthritis. Curr Opin Rheumatol 19, 246-251 (2007).
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 246-251
    • Asquith, D.L.1    McInnes, I.B.2
  • 16
    • 0037003871 scopus 로고    scopus 로고
    • IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis
    • Losy, J., Niezgoda, A., Zaremba, J. IL-15 is elevated in sera of patients with relapsing-remitting multiple sclerosis. Folia Neuropathol 40, 151-153 (2002).
    • (2002) Folia Neuropathol , vol.40 , pp. 151-153
    • Losy, J.1    Niezgoda, A.2    Zaremba, J.3
  • 17
    • 0034869941 scopus 로고    scopus 로고
    • Serum interleukin-15 is elevated in systemic lupus erythematosus
    • Aringer, M. et al. Serum interleukin-15 is elevated in systemic lupus erythematosus. Rheumatology 40, 876-881 (2001).
    • (2001) Rheumatology , vol.40 , pp. 876-881
    • Aringer, M.1
  • 18
    • 84928768698 scopus 로고    scopus 로고
    • IL-15 Agonists: The Cancer Cure Cytokine
    • Wu, J. IL-15 Agonists: The Cancer Cure Cytokine. J Mol Genet Med 7, 85 (2013).
    • (2013) J Mol Genet Med , vol.7 , pp. 85
    • Wu, J.1
  • 19
    • 0032076635 scopus 로고    scopus 로고
    • Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15
    • Zhang, X., Sun, S., Hwang, I., Tough, D. F., Sprent, J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8, 591-599 (1998).
    • (1998) Immunity , vol.8 , pp. 591-599
    • Zhang, X.1    Sun, S.2    Hwang, I.3    Tough, D.F.4    Sprent, J.5
  • 20
    • 70449533145 scopus 로고    scopus 로고
    • Macrophage-and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets
    • Mortier, E. et al. Macrophage-and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity 31, 811-822 (2009).
    • (2009) Immunity , vol.31 , pp. 811-822
    • Mortier, E.1
  • 21
    • 70249096718 scopus 로고    scopus 로고
    • Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs
    • Ma, L. J., Acero, L. F., Zal, T., Schluns, K. S. Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J Immunol 183, 1044-1054 (2009).
    • (2009) J Immunol , vol.183 , pp. 1044-1054
    • Ma, L.J.1    Acero, L.F.2    Zal, T.3    Schluns, K.S.4
  • 22
    • 77957729547 scopus 로고    scopus 로고
    • Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation
    • Castillo, E. F., Acero, L. F., Stonier, S. W., Zhou, D., Schluns, K. S. Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood 116, 2494-2503 (2010).
    • (2010) Blood , vol.116 , pp. 2494-2503
    • Castillo, E.F.1    Acero, L.F.2    Stonier, S.W.3    Zhou, D.4    Schluns, K.S.5
  • 23
    • 80051630275 scopus 로고    scopus 로고
    • IL-15Ralpha of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation
    • Chang, C. L., Lai, Y. G., Hou, M. S., Huang, P. L., Liao, N. S. IL-15Ralpha of radiation-resistant cells is necessary and sufficient for thymic invariant NKT cell survival and functional maturation. J Immunol 187, 1235-1242 (2011).
    • (2011) J Immunol , vol.187 , pp. 1235-1242
    • Chang, C.L.1    Lai, Y.G.2    Hou, M.S.3    Huang, P.L.4    Liao, N.S.5
  • 24
    • 0034970328 scopus 로고    scopus 로고
    • Identification of committed NK cell progenitors in adult murine bone marrow
    • Rosmaraki, E. E. et al. Identification of committed NK cell progenitors in adult murine bone marrow. Eur J Immunol 31, 1900-1909 (2001).
    • (2001) Eur J Immunol , vol.31 , pp. 1900-1909
    • Rosmaraki, E.E.1
  • 25
    • 67049114093 scopus 로고    scopus 로고
    • Maturation of mouse NK cells is a 4-stage developmental program
    • Chiossone, L. et al. Maturation of mouse NK cells is a 4-stage developmental program. Blood 113, 5488-5496 (2009).
    • (2009) Blood , vol.113 , pp. 5488-5496
    • Chiossone, L.1
  • 26
    • 34247170073 scopus 로고    scopus 로고
    • NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    • Huntington, N. D. et al. NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol 178, 4764-4770 (2007).
    • (2007) J Immunol , vol.178 , pp. 4764-4770
    • Huntington, N.D.1
  • 27
    • 84896713527 scopus 로고    scopus 로고
    • KLRG1+ NK cells protect T-bet-deficient mice from pulmonary metastatic colorectal carcinoma
    • Malaise, M. et al. KLRG1+ NK cells protect T-bet-deficient mice from pulmonary metastatic colorectal carcinoma. J Immunol 192, 1954-1961 (2014).
    • (2014) J Immunol , vol.192 , pp. 1954-1961
    • Malaise, M.1
  • 28
    • 80051630276 scopus 로고    scopus 로고
    • Different NK cell developmental events require different levels of IL-15 trans-presentation
    • Lee, G. A. et al. Different NK cell developmental events require different levels of IL-15 trans-presentation. J Immunol 187, 1212-1221.
    • J Immunol , vol.187 , pp. 1212-1221
    • Lee, G.A.1
  • 29
    • 71649083586 scopus 로고    scopus 로고
    • Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation
    • Castillo, E. F., Stonier, S. W., Frasca, L., Schluns, K. S. Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. J Immunol 183, 4948-4956 (2009).
    • (2009) J Immunol , vol.183 , pp. 4948-4956
    • Castillo, E.F.1    Stonier, S.W.2    Frasca, L.3    Schluns, K.S.4
  • 30
    • 58149390259 scopus 로고    scopus 로고
    • Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation
    • Stonier, S. W., Ma, L. J., Castillo, E. F., Schluns, K. S. Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation. Blood 112, 4546-4554 (2008).
    • (2008) Blood , vol.112 , pp. 4546-4554
    • Stonier, S.W.1    Ma, L.J.2    Castillo, E.F.3    Schluns, K.S.4
  • 31
    • 35748950110 scopus 로고    scopus 로고
    • The trafficking of natural killer cells
    • Gregoire, C. et al. The trafficking of natural killer cells. Immunol Rev 220, 169-182 (2007).
    • (2007) Immunol Rev , vol.220 , pp. 169-182
    • Gregoire, C.1
  • 32
    • 84916898536 scopus 로고    scopus 로고
    • The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages
    • Gillgrass, A., Gill, N., Babian, A., Ashkar, A. A. The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages. J Immunol 193, 6184-6191 (2014).
    • (2014) J Immunol , vol.193 , pp. 6184-6191
    • Gillgrass, A.1    Gill, N.2    Babian, A.3    Ashkar, A.A.4
  • 33
    • 80053371978 scopus 로고    scopus 로고
    • IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice
    • Takeda, K. et al. IFN-gamma production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice. J Leukoc Biol 90, 777-785 (2011).
    • (2011) J Leukoc Biol , vol.90 , pp. 777-785
    • Takeda, K.1
  • 34
    • 84944447448 scopus 로고    scopus 로고
    • IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity
    • Bahri, R. et al. IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity. Oncoimmunology 4, e1002721 (2015).
    • (2015) Oncoimmunology , vol.4 , pp. e1002721
    • Bahri, R.1
  • 35
    • 84860150685 scopus 로고    scopus 로고
    • Densely granulated murine NK cells eradicate large solid tumors
    • Liu, R. B. et al. Densely granulated murine NK cells eradicate large solid tumors. Cancer Res 72, 1964-1974 (2012).
    • (2012) Cancer Res , vol.72 , pp. 1964-1974
    • Liu, R.B.1
  • 36
    • 84877845953 scopus 로고    scopus 로고
    • IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner
    • Liu, R. B. et al. IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad of Sci USA 110, 8158-8163 (2013).
    • (2013) Proc Natl Acad of Sci USA , vol.110 , pp. 8158-8163
    • Liu, R.B.1
  • 37
    • 84866537220 scopus 로고    scopus 로고
    • Molecular definition of the identity and activation of natural killer cells
    • Bezman, N. A. et al. Molecular definition of the identity and activation of natural killer cells. Nature Immunol 13, 1000-1009 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 1000-1009
    • Bezman, N.A.1
  • 38
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon, K. C. et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J Clin Oncol 33, 74-82 (2015).
    • (2015) J Clin Oncol , vol.33 , pp. 74-82
    • Conlon, K.C.1
  • 39
    • 84931391331 scopus 로고    scopus 로고
    • Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency
    • Zhang, Y. et al. Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency. Oncoimmunology 3, e959321 (2014).
    • (2014) Oncoimmunology , vol.3 , pp. e959321
    • Zhang, Y.1
  • 40
    • 0035554678 scopus 로고    scopus 로고
    • Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
    • Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nature Immunol 2, 882-888 (2001).
    • (2001) Nature Immunol , vol.2 , pp. 882-888
    • Granucci, F.1
  • 41
    • 79955700857 scopus 로고    scopus 로고
    • A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy
    • Wuest, S. C. et al. A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nature medicine 17, 604-609 (2011).
    • (2011) Nature Medicine , vol.17 , pp. 604-609
    • Wuest, S.C.1
  • 42
    • 84890422383 scopus 로고    scopus 로고
    • Dendritic cell derived cytokines in human natural killer cell differentiation and activation
    • Chijioke, O., Munz, C. Dendritic cell derived cytokines in human natural killer cell differentiation and activation. Front Immunol 4, 365 (2013).
    • (2013) Front Immunol , vol.4 , pp. 365
    • Chijioke, O.1    Munz, C.2
  • 43
    • 79954603487 scopus 로고    scopus 로고
    • Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Ralpha
    • Sato, N. et al. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Ralpha. Blood 117, 4032-4040 (2011).
    • (2011) Blood , vol.117 , pp. 4032-4040
    • Sato, N.1
  • 44
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce, J. P. et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9, 669-676 (1998).
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1
  • 45
    • 45549105692 scopus 로고    scopus 로고
    • Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection
    • Schaefer, M. et al. Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunoly 180, 6836-6845 (2008).
    • (2008) J Immunoly , vol.180 , pp. 6836-6845
    • Schaefer, M.1
  • 46
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., Riedinger, M., Karjalainen, K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 185, 541-550 (1997).
    • (1997) J Exp Med , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 47
    • 0033012030 scopus 로고    scopus 로고
    • An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    • Lutz, M. B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223, 77-92 (1999).
    • (1999) J Immunol Methods , vol.223 , pp. 77-92
    • Lutz, M.B.1
  • 48
    • 0016781810 scopus 로고
    • Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms
    • Galanos, C., Luderitz, O. Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms. Eur J Biochem 54, 603-610 (1975).
    • (1975) Eur J Biochem , vol.54 , pp. 603-610
    • Galanos, C.1    Luderitz, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.